全文获取类型
收费全文 | 403篇 |
免费 | 33篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 8篇 |
基础医学 | 26篇 |
口腔科学 | 6篇 |
临床医学 | 28篇 |
内科学 | 196篇 |
皮肤病学 | 8篇 |
神经病学 | 54篇 |
特种医学 | 24篇 |
外科学 | 22篇 |
综合类 | 7篇 |
预防医学 | 11篇 |
眼科学 | 1篇 |
药学 | 16篇 |
中国医学 | 2篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 9篇 |
2022年 | 17篇 |
2021年 | 27篇 |
2020年 | 24篇 |
2019年 | 14篇 |
2018年 | 15篇 |
2017年 | 19篇 |
2016年 | 12篇 |
2015年 | 17篇 |
2014年 | 23篇 |
2013年 | 21篇 |
2012年 | 28篇 |
2011年 | 20篇 |
2010年 | 8篇 |
2009年 | 8篇 |
2008年 | 27篇 |
2007年 | 28篇 |
2006年 | 22篇 |
2005年 | 12篇 |
2004年 | 10篇 |
2003年 | 15篇 |
2002年 | 11篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1997年 | 6篇 |
1996年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 2篇 |
1966年 | 3篇 |
排序方式: 共有444条查询结果,搜索用时 15 毫秒
1.
H. Kaufmann E. Oribe M. D. Yahr 《Journal of neural transmission (Vienna, Austria : 1996)》1991,3(2):143-148
Summary Treatment with L-threo-3,4-dihydroxyphenylserine (L-threo-dops), a synthetic precursor of norepinephrine, significantly increased upright blood pressure in patients with multiple system atrophy but had no effect on the upright blood pressure of patients with pure autonomic failure. These results suggest that the site of action of L-threo-dops is central and that its pressor effect requires intact peripheral sympathetic neurons. 相似文献
2.
3.
Potentiation of allergic bronchoconstriction by repeated exposure to formaldehyde in guinea-pigs in vivo 总被引:2,自引:0,他引:2
T. Kita M. Fujimura S. Myou Y. Ishiura M. Abo N. Katayama M. Nishitsuji Y. Yoshimi S. Nomura Y. Oribe S. Nakao 《Clinical and experimental allergy》2003,33(12):1747-1753
BACKGROUND: Indoor formaldehyde (FA) might worsen allergies and be an underlying factor for the increasing incidence and severity of asthma; the exact mechanism, however, remains unclear. OBJECTIVE: The present study examined the effects of repeated exposure to FA on methacholine- and antigen-induced bronchoconstriction in guinea-pigs in vivo. METHODS: First, non-sensitized guinea-pigs were transnasally treated with 0.1 or 1.0% FA or saline three times a week for 6 weeks, and increasing concentrations of methacholine (50, 100, and 200 microg/mL) were inhaled at 5-min intervals. Second, guinea-pigs pre-treated with transnasal administration of FA or saline using the same protocol were passively sensitized with anti-ovalbumin (OA) serum 7 days before antigen challenge. Third, guinea-pigs were actively sensitized with OA and pre-treated with transnasal administration of FA or saline using the same protocol. The lateral pressure of the tracheal tube (Pao) was measured under anesthesia and artificial ventilation. RESULTS: The antigen-induced increase in Pao in actively sensitized guinea-pigs was significantly potentiated by FA exposure in a dose-dependent manner. The dose-response curve of the methacholine-induced increase in Pao in non-sensitized guinea-pigs or of the antigen-induced increase in Pao in passively sensitized guinea-pigs was not altered by FA exposure. Transnasal administration of FA significantly increased the serum anti-OA homocytotropic antibody titre (IgG) as measured by the passive cutaneous anaphylaxis reaction in actively sensitized guinea-pigs. CONCLUSION: The results suggest that repeated exposure to FA worsens allergic bronchoconstriction through enhancing antigen sensitization. 相似文献
4.
Horiuchi T Tsukamoto H Mitoma H Miyagawa H Tamimoto Y Yoshizawa S Harada M Hayashi K Hashimura C Oribe M Okamura S 《International journal of molecular medicine》2004,14(5):813-818
Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and in patients with the autoimmune disorders, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Genomic DNA from the members of a family with typical TRAPS, as well as from 100 patients with SLE, 100 patients with RA and 100 healthy individuals, was studied for mutations in exons 2, 3 and 4 of the TNFRSF1A gene. All individuals were Japanese. Three novel missense mutations were identified in the TNFRSF1A. The C70G mutation was identified in family members with typical TRAPS, which was the second case in eastern Asian population. In addition, the T61I and R104Q mutations were each identified in 2 of the 100 SLE patients. The T61I mutation was identified in one of the 100 healthy individuals. No mutations were identified in the 100 RA patients. Functional analysis revealed that PMA-induced shedding of TNFRSF1A from PBMCs was impaired in a patient carrying T61I. A larger scale of study will clarify whether these two mutations, T61I and R104Q, are associated with chronic inflammatory disorders, such as SLE, or not. 相似文献
5.
Takafumi Mizuno Takao Hoshino Kentaro Ishizuka Sono Toi Ayako Nishimura Shuntaro Takahashi Sho Wako Kazuo Kitagawa 《Journal of atherosclerosis and thrombosis》2022,29(9):1393
Aims: We aimed to determine the characteristics and vascular outcomes of stroke in renal transplant (RT) recipients and compare them with those in patients on hemodialysis (HD) and those with no renal replacement therapy (RRT). Methods: In this prospective observational study, 717 patients (mean age, 70.8 years; male, 60.5%) with acute ischemic stroke within one week of onset were consecutively enrolled and followed for one year. The patients were classified into three groups: (1) living donor RT recipients (n=27); (2) patients on maintenance HD before the index stroke (n=39); and (3) those with no history of RRT (n=651). The primary outcome was a composite of major adverse cardiovascular events (MACE). Results: Diabetic nephropathy was the most common reason for RRT in both RT and HD patients. RT patients were more likely to have embolic stroke of undetermined source (33.3%) than others, whereas HD patients more often had cardioembolism (51.3%). No difference was observed in the MACE risk between the patients in RT and non-RRT groups (annual rate, 11.3% vs. 13.1%; log-rankP=0.82; hazard ratio [95% confidence interval], 0.92 [0.29-2.98]). In contrast, HD patients had a greater risk of MACE than those with no RRT (annual rate, 28.2% vs. 13.1%; log-rankP=0.019; hazard ratio [95% confidence interval], 2.24 [1.16-4.3]). Conclusions: The underlying etiologies of stroke differed in RT and HD patients. The one-year risk of MACE for stroke patients who had received an RT was lower than that for patients undergoing HD and comparable with that of patients with no RRT. 相似文献
6.
7.
Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study 下载免费PDF全文
8.
Novel ex vivo training model for freehand insertion using a double‐bending peroral direct cholangioscope 下载免费PDF全文
9.
Cough variant asthma is known as a major cause of chronic cough. Fundamental features of cough variant asthma are prolonged nonproductive cough responding to bronchodilator therapy, no history of wheezing or dyspnea attack, normal cough sensitivity, and slightly increased bronchial responsiveness. Animal model of cough variant asthma has not been reported. The aim of this study was to establish an animal model for studying detailed pathophysiology of cough variant asthma. Bronchial responsiveness to methacholine and cough reflex sensitivity to capsaicin were measured 72 hours after antigen (ovalbumin, OA) inhalation in actively sensitized guinea pigs. Next, cough number and specific airway resistance (sRaw) were measured during 20 minutes following reinhalation of OA solution, which was carried out 72 hours after the first OA inhalation, and then total cell number and cell differentials in bronchoalveolar lavage fluid (BALE) were measured. Bronchial responsiveness to methacholine, but not cough reflex sensitivity to capsaicin, was significantly increased 72 hours after the first inhalation of OA solution. Number of coughs, sRaw and total cell number in BALF increased significantly by the OA reinhalation, and the cough number and the increase in sRaw were significantly suppressed by beta2 agonist, procaterol. FK224, a specific neurokinin (NK) receptor antagonist, did not significantly influence the OA reinhalation-induced cough and increase in sRaw and total cell number in BALF in this model In conclusion, pathophysiologic feature of this animal model is similar to that of clinical cough variant asthma. Tachykinins may not play an important part in antigen-induced cough associated with bronchoconstriction and airway inflammation in cough variant asthma. 相似文献
10.
Shuntaro Ando Kiyoto Kasai Misato Matamura Yukako Hasegawa Hiroyuki Hirakawa Nozomu Asukai 《Journal of affective disorders》2013