排序方式: 共有36条查询结果,搜索用时 15 毫秒
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Mattsson N Rosén E Hansson O Andreasen N Parnetti L Jonsson M Herukka SK van der Flier WM Blankenstein MA Ewers M Rich K Kaiser E Verbeek MM Olde Rikkert M Tsolaki M Mulugeta E Aarsland D Visser PJ Schröder J Marcusson J de Leon M Hampel H Scheltens P Wallin A Eriksdotter-Jönhagen M Minthon L Winblad B Blennow K Zetterberg H 《Neurology》2012,78(7):468-476
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Taina A. Partanen Pia Vuola Suvi Jauhiainen Jouko Lohi P?ivi Salminen Anne Pitk?ranta Sanna-Kaisa H?kkinen Krista Honkonen Kari Alitalo Seppo Yl?-Herttuala 《Angiogenesis》2013,16(1):137-146
Despite multiple previous studies in the field of vascular anomalies, the mechanism(s) leading to their development, progression and maintenance has remained unclear. In this study, we have characterized the expression levels of vascular endothelial growth factors and their receptors in 33 human vascular anomalies. Analysis with quantitative real-time PCR and gene-specific assays showed higher expression of neuropilin-2 (NRP2) and VEGF-receptor-3 (VEGFR-3) mRNAs in vascular malformations (VascM) as compared to infantile hemangiomas (Hem). In addition, the expression levels of PlGF and VEGF-C mRNA were significantly higher in venous VascM when compared to the other VascM and Hem. Higher expression of NRP2 and VEGFR-3 were confirmed by immunohistochemistry. To further study the importance of NRP2 and VEGFR-3, endothelial cell (EC) cultures were established from vascular anomalies. It was found that NRP2 and VEGFR-3 mRNA levels were significantly higher in some of the VascM ECs as compared to human umbilical vein ECs which were used as control cells in the study. Furthermore, adenoviral delivery of soluble decoy NRP2 prevented the proliferation of ECs isolated from most of the vascular anomalies. Our findings suggest that NRP2 functions as a factor maintaining the pathological vascular network in these anomalies. Thus, NRP2 could become a potential therapeutic target for the diagnosis and treatment of vascular anomalies. 相似文献
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Lamsa R Helisalmi S Herukka SK Tapiola T Pirttila T Vepsalainen S Hiltunen M Soininen H 《Dementia and geriatric cognitive disorders》2007,24(2):146-150
BACKGROUND: In Alzheimer's disease (AD) the beta-amyloid precursor protein is excessively cleaved into Abeta(42), causing the abundant amyloid plaque loads in affected brain areas. Sterol O-acyltransferase 1 (SOAT1) has been found to regulate the production of beta-amyloid precursor protein. METHODS: We genotyped 4 SOAT1 single nucleotide polymorphism (SNP) sites (rs2247071, rs2862616, rs3753526 and rs1044925) in 410 Finnish AD cases and 455 controls and conducted a single allele and genotypic distribution comparison as well as estimating the haplotype frequencies between cases and controls and the level of biomarkers in genotype and haplotype carriers. RESULTS: The CC genotype of rs2247071 was overrepresented in the AD cases (OR = 1.38, 95% CI = 1.01-1.89, p = 0.043, Bonferroni corrected p = 0.172 with 4 tests) independent of gender, age and APOE epsilon4 allele carrier status. We did not find any significant differences between Abeta(42), tau or ptau levels in different allele, genotype or haplotype carrier cases. CONCLUSION: Our findings suggest that SOAT1 gene may possibly be only a minor risk factor in AD. 相似文献
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Antti J. Luikku Anette Hall Ossi Nerg Anne M. Koivisto Mikko Hiltunen Seppo Helisalmi Sanna-Kaisa Herukka Anna Sutela Maria Kojoukhova Jussi Mattila Jyrki Lötjönen Jaana Rummukainen Irina Alafuzoff Juha E. Jääskeläinen Anne M. Remes Hilkka Soininen Ville Leinonen 《Acta neurochirurgica》2016,158(12):2311-2319
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Casarotto S Määttä S Herukka SK Pigorini A Napolitani M Gosseries O Niskanen E Könönen M Mervaala E Rosanova M Soininen H Massimini M 《Neuroreport》2011,22(12):592-597
The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment. 相似文献
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Sanna-Kaisa Herukka Anja Hviid Simonsen Niels Andreasen Ines Baldeiras Maria Bjerke Kaj Blennow Sebastiaan Engelborghs Giovanni B. Frisoni Tomasz Gabryelewicz Samantha Galluzzi Ron Handels Milica G. Kramberger Agnieszka Kulczyńska Jose Luis Molinuevo Barbara Mroczko Agneta Nordberg Catarina Resende Oliveira Markus Otto Gunhild Waldemar 《Alzheimer's & dementia》2017,13(3):285-295
This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1–42, tau, and phosphorylated tau in the diagnostic evaluation of patients with mild cognitive impairment (MCI). The recommendations were developed by a multidisciplinary working group and based on the available evidence and consensus from focused group discussions for 1) prediction of clinical progression to Alzheimer's disease (AD) dementia, 2) cost-effectiveness, 3) interpretation of results, and 4) patient counseling. The working group recommended using CSF AD biomarkers in the diagnostic workup of MCI patients, after prebiomarker counseling, as an add-on to clinical evaluation to predict functional decline or conversion to AD dementia and to guide disease management. Because of insufficient evidence, it was uncertain whether CSF AD biomarkers outperform imaging biomarkers. Furthermore, the working group provided recommendations for interpretation of ambiguous CSF biomarker results and for pre- and post-biomarker counseling. 相似文献
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Katisko Kasper Solje Eino Korhonen Paula Jääskeläinen Olli Loppi Sanna Hartikainen Päivi Koivisto Anne M. Kontkanen Aleksi Korhonen Ville E. Helisalmi Seppo Malm Tarja Herukka Sanna-Kaisa Remes Anne M. Haapasalo Annakaisa 《Journal of neurology》2020,267(1):76-86
Journal of Neurology - In this study, our aim was to evaluate potential peripheral inflammatory changes in frontotemporal lobar degeneration (FTLD) patients carrying or not the C9orf72 repeat... 相似文献