Decreased gray matter volume (GMV) in the superior temporal gyrus (STG) has been implicated in the neurophysiology of schizophrenia. However, it remains unclear whether volumetric reduction in the subregions of the STG can predict treatment efficacy for schizophrenia. Our cohort included 44 drug-naive, first-episode patients, 42 unaffected siblings and 44 healthy controls. Voxel-based morphometry and pattern classification were utilized to analyze the acquired imaging data as per the anatomical subdivision by a well-defined brainnetome atlas. The patients presented lower GMV values in left TE1.0/1.2 (TE, anterior temporal visual association area) than the siblings, and lower GMV values in the left/right TE1.0/1.2 and left A22r (rostral area 22) than the controls. A positive correlation is observed between the GMV values in the right A38l (lateral area 38) and baseline Positive and Negative Syndrome Scale (PANSS) total scores in the patients. Support vector regression (SVR) results exhibited a significant association between predicted (based on the GMV values in the right A38l) and actual symptomatic improvement based on the reduction ratio of the PANSS total scores (r = 0.498, p = 0.001). Our results suggest that normal structure in the right A38l of the STG may be an important factor indicative of the effects of antipsychotic drugs, which can be potentially used to monitor drug effects for first-episode patients at an early stage in clinical practice.
Single atom catalysis is a prosperous and rapidly growing research field, owing to the remarkable advantages of single atom catalysts (SACs), such as maximized atom utilization efficiency, tailorable catalytic activities as well as supremely high catalytic selectivity. Synthesis approaches play crucial roles in determining the properties and performance of SACs. Over the past few years, versatile methods have been adopted to synthesize SACs. Herein, we give a thorough and up-to-date review on the progress of approaches for the synthesis of SACs, outline the general principles and list the advantages and disadvantages of each synthesis approach, with the aim to give the readers a clear picture and inspire more studies to exploit novel approaches to synthesize SACs effectively.The two routes for the synthesis of SACs are reviewed and the advantages and disadvantages of each method are compared.相似文献