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1.
PJ Commerford 《Cardiovascular journal of Africa》2015,26(4):151-Aug;26(4):151
2.
Hugo Maia Julio Casoy Tania Correia Luís Freitas Kleber Pimentel Célia Athayde Elsimar Coutinho 《Gynecological endocrinology》2006,22(10):547-551
OBJECTIVES: To determine whether aromatase expression in the eutopic endometrium and adenomyotic foci is affected by previous use of oral contraceptives containing gestodene, and to determine whether changes in cyclooxygenase-2 (COX-2) expression occur in adenomyosis during the menstrual cycle. PATIENT AND METHODS: This was a retrospective cohort study carried out in paraffin-embedded endometrial tissue obtained from patients with a histological diagnosis of adenomyosis obtained during the proliferative (n = 25) and luteal (n = 10) phases of the menstrual cycle and following the use of continuous oral contraception with gestodene/ethinyl estradiol (n = 7). COX-2 and aromatase expression were measured in both eutopic endometrium and adenomyotic foci using immunohistochemical methods. RESULTS: Aromatase expression was detected in 80% of the endometrial slices by immunohistochemistry. In positive cases, aromatase was mainly detected in the stromal cells of the eutopic endometrium, whereas in the adenomyotic foci this expression was negative in the majority of the cases. Oral contraceptives containing gestodene, on the other hand, were effective in suppressing aromatase expression in both eutopic and ectopic endometrium. COX-2 expression was detected by immunohistochemistry in the glandular epithelium of both eutopic endometrium and adenomyotic foci and there were no significant changes in its intensity throughout the menstrual cycle. CONCLUSION: Aromatase expression in the eutopic endometrium and adenomyotic foci is suppressed by oral contraceptives containing gestodene. Increased aromatase activity may be responsible for the persistent COX-2 expression during the luteal phase. 相似文献
3.
Anya Pimentel Gomes Fernandes Vieira Jose Maria Sampaio Meneses Jr Renato Luiz Maia 《Journal of oral pathology & medicine》2007,36(2):117-119
Cementoblastomas are benign lesions of the odontogenic ectomesenchyme that rarely occur related to the primary dentition, especially on the left side of the mandible. This study describes a case of a true cementoblastoma related to the left second primary mandibular molar in a 7-year-old child (the largest one seen in the left side of the mandible). Additionally, the radiographic and histologic findings of the lesion are described in details. 相似文献
4.
Hans Bosma Martin PJ van Boxtel Gertrudis IJM Kempen Jacques ThM van Eijk Jelle Jolles 《BMC public health》2007,7(1):179
Background
The aims of this study were to examine the extent to which higher intellectual abilities protect higher socio-economic groups from functional decline and to examine whether the contribution of intellectual abilities is independent of childhood deprivation and low birth weight and other socio-economic and developmental factors in early life. 相似文献5.
6.
Therapy of post-renal transplantation hyperlipidaemia: comparative study with simvastatin and fish oil 总被引:1,自引:0,他引:1
Castro R; Queiros J; Fonseca I; Pimentel J; Henriques A; Sarmento A; Guimaraes S; Pereira M 《Nephrology, dialysis, transplantation》1997,12(10):2140-2143
Background: Recipients of renal transplantation (RT)
exhibit disturbances of serum lipids and apoproteins that may contribute to
their cardiovascular morbidity and mortality. In our renal transplant
department the hypercholesterolaemia prevalence at the first and fifth year
of RT is 70.0% and 81.2%, respectively. Lipid-lowering therapy has been
utilized in many Transplant Units. The aim of our study was to evaluate
post-RT hyperlipidaemia control with simvastatin or fish oil.
Method: Forty-three RT patients (26 men and 17 women)
with persistent hypercholesterolaemia and stable graft function which were
resistant to a lipid-lowering diet (American Heart Association Step Two)
were randomized into two groups and treated for 3 months with simvastatin
(S) (10 mg/day; n=25) and fish oil (F) (6 g/day; n=18). Total cholesterol
(TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), lipoprotein a
(Lp(a)), apolipoprotein A1 (Apo A1), and apolipoprotein B (Apo B) were
monitored and at the study baseline they were similar between the two
groups. Results: No side effects were detected after 3
months of therapy. In group S, the concentrations of TC (271±46
mg% vs 228±49mg%; P <0.001), TG (180±78 vs
134±45; P<0.01), LDL-C (177& plusmn;40 vs
144±43; P <0.01) and Apo B (96±18 vs
82±16; P <0.001) were significantly reduced, and Apo A1
concentration had increased (135±24 vs 149±30; P
<0.01). In group F, the concentrations of TC (266±25 vs
240±31; P <0.001), TG (203±105 vs
156±72; P=0.02) and HDL-C (63±15 vs 53±12;
P <0.01) were significantly reduced.
Conclusion: We concluded that low-dose simvastatin and
fish oil are both effective and safe in correcting post-RT hyperlipidaemia.
Further prospective studies with larger follow-up are needed to clarify
whether this therapy has an impact on cardiovascular morbidity and
mortality in RT patients. 相似文献
7.
8.
Previous reports in the literature have described correlation of increasing repeat length with severity of the phenotype, in Kennedy syndrome. We describe male siblings with different repeat lengths, with lack of expression of the phenotype in the sibling with the longer repeat length. The phenotype was identical to motor neurone disease. There is variability of expression in Kennedy syndrome and repeat length even in siblings cannot be taken as a conclusive indicator of severity. CAG repeat length cannot be used to predict the natural history of Kennedy disease. The diagnosis of Kennedy syndrome should be considered in male patients presenting with atypical motor neurone disease. 相似文献
9.
PJ Woll PhD MRCP R Pettengell PhD FRACP 《International journal of clinical practice》1997,51(2):111-115
SUMMARY The interferons are natural glycoproteins secreted in response to various stimuli, including viral infection. They have antiviral, antiproliferative and immunomodulatory effects on different target cell populations. Since recombinant human interferons have become available, they have been tested in a wide range of malignancies. They are well established in the treatment of hairy cell leukaemia, chronic myelogenous leukaemia and multiple myeloma. Although they have documented activity against lymphoma, melanoma, renal cell cancer and carcinoid tumours, their role in the treatment of these tumours is less clear. In the common solid tumours, such as lung cancer and colorectal cancer, the use of interferons remains experimental. Here we will summarise their practice applications in oncology, using randomised studies where available to establish their place in multi-modality treatment. We will not discuss their use as antiviral or immunomodulating agents in viral and autoimmune diseases, multiple sclerosis or after organ transplantation. 相似文献
10.