全文获取类型
收费全文 | 733篇 |
免费 | 61篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 43篇 |
妇产科学 | 6篇 |
基础医学 | 79篇 |
口腔科学 | 6篇 |
临床医学 | 86篇 |
内科学 | 134篇 |
皮肤病学 | 3篇 |
神经病学 | 46篇 |
特种医学 | 83篇 |
外科学 | 98篇 |
综合类 | 9篇 |
预防医学 | 129篇 |
眼科学 | 10篇 |
药学 | 47篇 |
肿瘤学 | 15篇 |
出版年
2021年 | 17篇 |
2020年 | 11篇 |
2019年 | 16篇 |
2018年 | 18篇 |
2017年 | 11篇 |
2016年 | 21篇 |
2015年 | 10篇 |
2014年 | 18篇 |
2013年 | 36篇 |
2012年 | 18篇 |
2011年 | 34篇 |
2010年 | 18篇 |
2009年 | 9篇 |
2008年 | 30篇 |
2007年 | 25篇 |
2006年 | 26篇 |
2005年 | 32篇 |
2004年 | 33篇 |
2003年 | 21篇 |
2002年 | 23篇 |
2001年 | 21篇 |
2000年 | 17篇 |
1999年 | 30篇 |
1998年 | 13篇 |
1997年 | 11篇 |
1996年 | 20篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 14篇 |
1992年 | 12篇 |
1991年 | 16篇 |
1990年 | 12篇 |
1989年 | 21篇 |
1988年 | 17篇 |
1987年 | 14篇 |
1986年 | 21篇 |
1985年 | 14篇 |
1984年 | 7篇 |
1983年 | 10篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1976年 | 7篇 |
1974年 | 5篇 |
1973年 | 6篇 |
1972年 | 4篇 |
1970年 | 8篇 |
1969年 | 4篇 |
1968年 | 5篇 |
排序方式: 共有799条查询结果,搜索用时 15 毫秒
1.
2.
Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease 总被引:1,自引:0,他引:1
Positron emission tomography (PET) with fluorodeoxyglucose (FDG), magnetic resonance imaging (MRI), and CT were carried out in a patient with Alzheimer's disease 16 months before he died. At autopsy, the gross appearance of the brain correlated with MRI and CT, which showed some regional atrophy. These were much less revealing than PET, which correlated with microscopic findings of neuronal loss and proliferation of glia. In areas of moderately impaired local cerebral metabolic rate of glucose, as revealed by reduced FDG uptake, there was some gliosis, primarily around the numerous senile plaques. In areas of severe metabolic impairment, there was a profound loss of neurons, extensive gliosis, and a diminished appearance of plaques. PET-FDG is a better measure of the severity of Alzheimer's disease than MRI or CT, because it reflects the degree of neuronal pathology. 相似文献
3.
4.
R W Pate 《The Nursing clinics of North America》1992,27(3):653-663
Lung carcinoma despite treatment continues to be a leading cause of cancer death. The use of chemotherapeutic agents in the treatment of lung cancer does not promise cure but can enhance the quality of life of those patients suffering from this disease. The nursing care plan is an effective tool in managing the patient's side effects of both the disease and its treatment. 相似文献
5.
6.
Genotype-phenotype correlation for nucleotide substitutions in the IgII- IgIII linker of FGFR2 总被引:6,自引:3,他引:3
7.
Development of capture assays for different modifications of human low-density lipoprotein 总被引:2,自引:0,他引:2
Virella G Derrick MB Pate V Chassereau C Thorpe SR Lopes-Virella MF 《Clinical and diagnostic laboratory immunology》2005,12(1):68-75
Antibodies to malondialdehyde (MDA)-modified low-density lipoprotein (LDL), copper-oxidized LDL (oxLDL), Nepsilon(carboxymethyl) lysine (CML)-modified LDL, and advanced glycosylation end product (AGE)-modified LDL were obtained by immunization of rabbits with in vitro-modified human LDL preparations. After absorption of apolipoprotein B (ApoB) antibodies, we obtained antibodies specific for each modified lipoprotein with unique patterns of reactivity. MDA-LDL antibodies reacted strongly with MDA-LDL and also with oxLDL. CML-LDL antibodies reacted strongly with CML-LDL and also AGE-LDL. oxLDL antibodies reacted with oxLDL but not with MDA-LDL, and AGE-LDL antibodies reacted with AGE-LDL but not with CML-LDL. Capture assays were set with each antiserum, and we tested their ability to capture ApoB-containing lipoproteins isolated from precipitated immune complexes (IC) and from the supernatants remaining after IC precipitation (free lipoproteins). All antibodies captured lipoproteins contained in IC more effectively than free lipoproteins. Analysis of lipoproteins in IC by gas chromatography-mass spectrometry showed that they contained MDA-LDL and CML-LDL in significantly higher concentrations than free lipoproteins. A significant correlation (r=0.706, P<0.019) was obtained between the MDA concentrations determined by chemical analysis and by the capture assay of lipoproteins present in IC. In conclusion, we have developed capture assays for different LDL modifications in human ApoB/E lipoprotein-rich fractions isolated from precipitated IC. This approach obviates the interference of IC in previously reported modified LDL assays and allows determination of the degree of modification of LDL with greater accuracy. 相似文献
8.
9.
C Camenzuli AN DiMarco KE Isaacs Y Grant J Jackson A Alsafi C Harvey TD Barwick N Tolley FF Palazzo 《Annals of the Royal College of Surgeons of England》2021,103(1):29
IntroductionReoperative parathyroidectomy for persistent and recurrent primary hyperparathyroidism is dependent on radiology. This study aimed to compare outcomes in reoperative parathyroidectomy at a single centre using a combination of traditional and newer imaging studies.Materials and methodsRetrospective case note review of all reoperative parathyroidectomies for persistent and recurrent primary hyperparathyroidism over five years (June 2014 to June 2019; group A). Imaging modalities used and their positive predictive value, complications and cure rates were compared with a published dataset spanning the preceding nine years (group B).ResultsFrom over 2000 parathyroidectomies, 147 were reoperations (101 in group A and 46 in group B). Age and sex ratios were similar (56 vs 62 years; 77% vs 72% female). Ultrasound use remains high and shows better positive predictive value (76% vs 57 %). 99mTc-sestamibi use has declined (79% vs 91%) but the positive predictive value has improved (74% vs 53%). 4DCT use has almost doubled (61% vs 37%) with better positive predictive value (88% vs 75%). 18F-fluorocholine positron emission tomography-computed tomography and ultrasound-guided fine-needle aspiration for parathyroid hormone are novel modalities only available for group A. Both carried a positive predictive value of 100%. Venous sampling with or without angiography use has decreased (35% vs 39%) but maintains a high positive predictive value (86% vs 91%). Cure rates were similar (96% vs 100%). Group A had 5% permanent hypoparathyroidism, 1% permanent vocal cord palsy and 1% haematoma requiring reoperation. No complications for group B.ConclusionOptimal imaging is key to good cure rates in reoperative parathyroidectomy. High-quality, non-interventional imaging techniques have produced a shift in the preoperative algorithm without compromising outcomes. 相似文献
10.