Introduction
Accurate diagnosis of prion diseases and discrimination from alternative dementias gain importance in the clinical routine, but partial overlap in cerebrospinal fluid (CSF) biomarkers impedes absolute discrimination in the differential diagnostic context.Methods
We established the clinical parameters for prion disease diagnosis for the quantification of CSF α-synuclein in patients with sporadic (n = 234) and genetic (n = 56) prion diseases, in cases with cognitive impairment/dementia or neurodegenerative disease (n = 278), and in the neurologic control group (n = 111).Results
An optimal cutoff value of 680 pg/mL α-synuclein results in 94% sensitivity and 96% specificity when diagnosing sporadic Creutzfeldt-Jakob disease (CJD). Genetic CJD cases showed increased CSF α-synuclein values. No increased α-synuclein levels were detected in non-CJD cases with rapid progression course.Discussion
Detection of α-synuclein in the CSF of patients with suspected CJD is a valuable diagnostic test reaching almost full discrimination from non-prion disease cases. These data highlight the utility of CSF α-synuclein quantification in front of classical CSF biomarkers in clinical routine. 相似文献Method: Young (n = 40) and older adults (n = 40) completed the Difficulties in Emotion Regulation Scale (DERS) and self-report measures of anxiety and depression.
Results: Whereas young and older adults did not differ in terms of acceptance and awareness of emotional responses, younger adults scored higher compared to older overall, indicating greater emotion regulation difficulties. Older adults reported greater ability in engaging in goal-directed behaviour, and refraining from impulsive emotional responses. Increasing age was associated with greater access to emotion regulation strategies and greater clarity of emotions.
Conclusion: Overall, the present cross-sectional results suggest a general stability in late adulthood in several aspects of emotion regulation, suggesting specific adaptations with increasing age. Findings provided support for the construct validity of the DERS and indicated that the relationship between age and emotion regulation is influenced by verbal ability. Current results extend the focus of age-related differences in emotion regulatory control to several theoretically defined forms of emotion regulation. 相似文献