全文获取类型
收费全文 | 903篇 |
免费 | 37篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 50篇 |
妇产科学 | 4篇 |
基础医学 | 107篇 |
口腔科学 | 11篇 |
临床医学 | 65篇 |
内科学 | 134篇 |
皮肤病学 | 8篇 |
神经病学 | 138篇 |
特种医学 | 86篇 |
外科学 | 82篇 |
综合类 | 124篇 |
预防医学 | 51篇 |
眼科学 | 10篇 |
药学 | 30篇 |
肿瘤学 | 41篇 |
出版年
2021年 | 28篇 |
2020年 | 6篇 |
2019年 | 7篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 7篇 |
2015年 | 13篇 |
2014年 | 14篇 |
2013年 | 20篇 |
2012年 | 23篇 |
2011年 | 15篇 |
2010年 | 28篇 |
2009年 | 28篇 |
2008年 | 32篇 |
2007年 | 27篇 |
2006年 | 37篇 |
2005年 | 29篇 |
2004年 | 32篇 |
2003年 | 29篇 |
2002年 | 28篇 |
2001年 | 27篇 |
2000年 | 22篇 |
1999年 | 29篇 |
1998年 | 38篇 |
1997年 | 26篇 |
1996年 | 33篇 |
1995年 | 22篇 |
1994年 | 36篇 |
1993年 | 12篇 |
1992年 | 11篇 |
1991年 | 9篇 |
1990年 | 22篇 |
1989年 | 28篇 |
1988年 | 25篇 |
1987年 | 26篇 |
1986年 | 26篇 |
1985年 | 22篇 |
1984年 | 12篇 |
1983年 | 12篇 |
1982年 | 8篇 |
1981年 | 12篇 |
1980年 | 12篇 |
1979年 | 12篇 |
1978年 | 5篇 |
1977年 | 4篇 |
1976年 | 7篇 |
1975年 | 7篇 |
1974年 | 4篇 |
1973年 | 3篇 |
1972年 | 3篇 |
排序方式: 共有943条查询结果,搜索用时 109 毫秒
1.
2.
A Thurkauf B de Costa M V Mattson C P France M T Price J W Olney J H Woods A E Jacobson K C Rice 《Journal of medicinal chemistry》1990,33(8):2211-2215
A series of 1-[1-arylcyclohexyl]-1,2,3,6-tetrahydropyridines were prepared by the reaction between 1-(1-cyanocyclohexyl)-1,2,3,6-tetrahydropyridine (1) and an appropriately substituted Grignard reagent. The resulting compounds were tested for their phencyclidine binding site affinities. Selected compounds were then tested for their ability to produce ketamine appropriate responding in monkeys and/or to show neuroprotective effects in a baby rat hypoxia/ischemia model. While it was found that binding site affinity correlated well with discriminative stimulus effects, it was found to be a poor indicator of neuroprotective efficacy within this series. 相似文献
3.
4.
5.
6.
HERMAN TOURNAYE RONNY JANSSENS PAUL DEVROEY RK VAN STEIRTEGHEM 《International journal of andrology》1994,17(1):1-8
In order to evaluate the effects of pentoxifylline on sperm motility and longevity, a controlled in-vitro study was conducted on normozoospermic donor semen samples using the Cellsoft automated system for sperm motility analysis. After incubation and selection, pentoxifylline was found to improve the recovery of spermatozoa and to increase their velocity. In the subgroup of progressively motile spermatozoa, curvilinear velocity was also enhanced. It is concluded that pentoxifylline has an effect on the vigour, but not on the pattern, of sperm motion. Pentoxifylline did not improve the motility characteristics of senescent spermatozoa in normozoospermic sperm samples. Sperm survival, as shown by supra-vital staining, and motility longevity both decreased with time after pentoxifylline treatment. 相似文献
7.
V. JNSSON H. D. SCHRDER W. TROJABORG T. STAEHELIN JENSEN E. HIPPE M. MRK HANSEN 《Journal of internal medicine》1992,232(2):185-191
A study of 17 patients with autoimmune axonal or demyelinating peripheral neuropathy in combination with M-component is described. The M-component was associated with MGUS (monoclonal gammopathy of undetermined significance) in 12 patients, CLL in one patient, WaldenstrÖm's disease in one patient, and myeloma in three patients. Immunohistological examination with direct and indirect fluorescence showed binding of antibodies to nerve structures of the same class and light chain as seen in the M-component. In five cases of IgM M-component, the demyelinating neuropathy was caused by binding of the IgM M-protein and complement C3b to myelin-associated glycoproteins (MAG). In 12 cases with axonal neuropathy, binding of IgG to the connective tissue of the peri- and endoneurium was found in 50% of cases, IgM in five cases, and IgD in one case. None of the patients had central nervous system (CNS) symptoms. The clinical and therapeutic difficulties are discussed; only two patients with an acute course responded to immunosuppression. A marked co-expression of other autoimmune phenomena is interpreted in the light of cross-reactions between the autoantibody and similar tissue autoantigens. 相似文献
8.
9.
Carmelo Romano Michael A. Sesma Colin T. McDonald Karen O'malley Anthony N. van den Pol John W. Olney 《The Journal of comparative neurology》1995,355(3):455-469
The receptor mGluR5 is a metabotropic glutamate receptor with messenger RNA abundantly present throughout cortex, hippocampus, and caudate/putamen that is also coupled to phosphatidyl inositide hydrolysis and calcium mobilization. In this study, the distribution of mGluR5 was examined in rat brain by immunocytochemistry. The antibody utilized is highly specific and does not cross react with the most closely related other metabotropic glutamate receptor, as determined by Western blot analysis of nonneuronal cells transfected with metabotropic receptor coding sequences. The receptor mGluR5 is widely expressed with the highest density in olfactory bulb, caudate/putamen, lateral septum, cortex, and hippocampus, as confirmed with both immunocytochemistry and Western blot analysis. Electron microscopic studies in hippocampus and cortex indicate that the labeling is mostly on membranes of dendritic spines and shafts. Light and electron microscopic evidence indicates that some mGluR5 immunoreactivity is located in presynaptic axon terminals, suggesting that mGluR5 may function as a presynaptic receptor. 相似文献
10.