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1.
Emergence of rifampin-resistant Rhodococcus equi with several types of mutations in the rpoB gene among AIDS patients in northern Thailand
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Asoh N Watanabe H Fines-Guyon M Watanabe K Oishi K Kositsakulchai W Sanchai T Kunsuikmengrai K Kahintapong S Khantawa B Tharavichitkul P Sirisanthana T Nagatake T 《Journal of clinical microbiology》2003,41(6):2337-2340
The antimicrobial susceptibilities of 30 Rhodococcus equi isolates obtained from 30 patients between 1993 and 2001 in northern Thailand were investigated. The MICs showed a tendency toward resistance to various antibiotics but sensitivity to imipenem, minocycline, vancomycin, and teicoplanin (MICs, =0.5 micro g/ml) and relative sensitivity to meropenem, clarithromycin, and ciprofloxacin (MICs, =2 micro g/ml). Of the 30 isolates, 26 were susceptible (MICs, =1 micro g/ml), 1 showed low-level resistance (MIC, 8 micro g/ml), and 3 showed high-level resistance (MICs, >/=64 micro g/ml) to rifampin. PCR amplification and DNA sequencing of the rpoB gene and molecular typing by pulsed-field gel electrophoresis (PFGE) were performed for eight R. equi isolates from eight AIDS patients with pneumonia or lung abscess caused by R. equi between 1998 and 2001, including one low- and three high-level rifampin-resistant isolates. As a result, two high-level rifampin-resistant strains with PFGE pattern A had a Ser531Trp (Escherichia coli numbering) mutation, and one high-level rifampin-resistant strain with PFGE pattern B had a His526Tyr mutation, whereas one low-level rifampin-resistant strain with PFGE pattern C had a Ser509Pro mutation. Four rifampin-susceptible strains with PFGE patterns D and E showed an absence of mutation in the rpoB region. Our results indicate the presence of several types of rifampin-resistant R. equi strains among AIDS patients in northern Thailand. 相似文献
2.
Morioka Atsuo; Iwashiro Michihiro; Matsubayashi Yuji; Teramura Yasuhumi; Kuribayashi Kagemasa 《International immunology》1994,6(6):839-846
This study showed that non-MHC genes common to (DBA/2 H-2d)and (DBA/1 H-2q) gave rise to suppressor T (Ta) cells in thehybrid F1 mice between C57BL/6 (B6) strain in the antl-FBL-3tumor responses. FBL-3, a Friend virus-induced tumor cell lineof B6 mouse origin, is highly immunogenic as shown by findingsthat syngenelc and hybrid F1 mice with several other inbredstrains rejected up to 3 x 107 tumor cells inoculated s.c. andgenerated potent CTL responses after mixed lymphocyte tumorcell culture. In contrast to these mice, (B6 x DBA/2) and (B6x DBA/1)F1 mice did not reject the tumor as the tumor dosesincreased. Progressive tumor growth in these F1 mice was blockedby an I.p. Injection of cyclophosphamlde (250 mg/kg) on day10, but not on day 5, after tumor cell inoculation. Antl-CD4(GK1.5) mAb exerted similar therapeutic effects against tumorwhen given twice, between day 0 and 10, whereas the additionalinjection of antl-CD8 mAb enhanced the tumor growth in micethat otherwise rejected the tumor. Thus, In the response of(B6 x DBA/2)F, mice to FBL-3 tumor cells, CD4+ T8 seemed todown-regulate the immunologically mediated regression of thetumor produced by CD8+ CTL. This was evidenced by limiting dilutionculture analyses, which showed that the frequency of an FBL-3-speclflcCTL precursor in the (B6 x DBA/2)F1 mice that rejected the tumorwith antl-CD4 mAb was 7- to 9-fold higher than that in micein which the tumor regressed spontaneously. That more than onegene was involved in suppressor T cell induction was shown bythe tumor growth pattern in (B6 x DBA/2)F1 x B6 backcross andB6D2F2 mice. 相似文献
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4.
Motomura K Masaki H Terada M Onizuka T Shimogama S Furumoto A Asoh N Watanabe K Oishi K Nagatake T 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》2004,78(3):277-282
Corynebacterium propinquum, which is included in Corynebacterium group ANF-3, exists as a commensal in the oral flora. This organism has not yet been fully recognized as a respiratory pathogen. We previously reported that the first case with respiratory infection caused by C. propinquum. On the other hand, Corynebacterium pseudodiphtheriticum is recognized as a causative organism in respiratory infections. Recently we experienced two cases with C. propinquum respiratory infections in our hospital. Three types of the onset such as a community-acquired infection, a hospital-acquired infection, and a nursing home acquired infections were observed. Our analysis indicated that gram staining of the purulent sputum is an essential tool to evaluate whether C. propinquum is a respiratory pathogen or not, because this organism is a commensal bacteria. 相似文献
5.
Tatsunobu Natsubori Hideyuki Inoue Osamu Abe Yosuke Takano Norichika Iwashiro Yuta Aoki Shinsuke Koike Noriaki Yahata Masaki Katsura Wataru Gonoi Hiroki Sasaki Hidemasa Takao Kiyoto Kasai Hidenori Yamasue 《Schizophrenia bulletin》2014,40(5):1128-1139
Changes in brain pathology as schizophrenia progresses have been repeatedly suggested by previous studies. Meta-analyses of previous proton magnetic resonance spectroscopy (1H MRS) studies at each clinical stage of schizophrenia indicate that the abnormalities of N-acetylaspartate (NAA) and glutamatergic metabolites change progressively. However, to our knowledge, no single study has addressed the possible differences in 1H MRS abnormalities in subjects at 3 different stages of disease, including those at ultrahigh risk for psychosis (UHR), with first-episode schizophrenia (FES), and with chronic schizophrenia (ChSz). In the current study, 24 patients with UHR, 19 FES, 25 ChSz, and their demographically matched 3 independent control groups (n = 26/19/28 for the UHR, FES, and ChSz control groups, respectively) underwent 1H MRS in a 3-Tesla scanner to examine metabolites in medial prefrontal cortex. The analysis revealed significant decreases in the medial prefrontal NAA and glutamate + glutamine (Glx) levels, specifically in the ChSz group as indexed by a significant interaction between stage (UHR/FES/ChSz) and clinical status (patients/controls) (P = .008). Furthermore, the specificity of NAA and Glx reductions compared with the other metabolites in the patients with ChSz was also supported by a significant interaction between the clinical status and types of metabolites that only occurred at the ChSz stage (P = .001 for NAA, P = .004 for Glx). The present study demonstrates significant differences in 1H MRS abnormalities at different stages of schizophrenia, which potentially correspond to changes in glutamatergic neurotransmission, plasticity, and/or excitotoxicity and regional neuronal integrity with relevance for the progression of schizophrenia.Key words: anterior cingulate cortex, at-risk mental state, biomarkers, frontal lobe, magnetic resonance imaging, neurochemical abnormality 相似文献
6.
7.
Correlation of neuron-specific enolase and S100B with histological cerebral damage in fetal sheep after severe asphyxia 总被引:2,自引:0,他引:2
Fujii EY Kozuki M Mu J Ino Y Ushioda N Tomimatsu T Fukuda H Kanzaki T Nakayama M Murata Y 《Brain research》2004,1018(1):136-140
Experimental brain damage was induced in 16 fetal sheep by umbilical cord occlusion, and the correlation of neuron-specific enolase (NSE) or S100B with the damage grade was investigated in seven fetuses. Significant correlations of damage degree with NSE (p = 0.016) and S100B (p = 0.018) in serum 2 h after insult were shown by Spearman's test. These findings suggest that they represent potentially useful markers for detecting brain damage at early stage after ischemic insult. 相似文献
8.
9.
Toshiya Nishibe Yoshiaki Satoh Nozomu Iwashiro Satoshi Hirano Setsuyuki Ohtake Hideki Ohkashiwa Satoshi Watanabe Hiroyuki Katoh Yasuhiro Okuda Tatsuzo Tanabe 《Surgery today》1997,27(2):149-153
This study was designed to reexamine the healing process of expanded polytetrafluoroethylene (EPTFE) grafts with standard
porosity (30μm) and high porosity (60μm) in portal vein replacement, and to evaluate the effect of an omentum wrap, which
has certain functions that promote healing, on graft healing. These grafts, either wrapped by the omentum or not, were placed
as portal vein replacements in 24 mongrel dogs. After 1 month, the grafts were retrieved and examined for patency, thrombus-free
areas, thickness of the pseudointima, and the total number of cells growing into the graft wall. There were no statistical
differences in the patency rates. The high-porosity grafts had a significantly larger thrombus-free area, a thicker pseudointima,
and a larger growth of cells than the standard-porosity grafts. The omentum wrap significantly increased the thrombus-free
area and stimulated a larger growth of cells in both grafts. The high-porosity grafts plus omentum demonstrated a thrombus-free
area of 82.2%vs 27.3% in the standard-porosity grafts. In addition, the migration of fibroblasts and macrophages was most evident in the
high-porosity grafts wrapped by the omentum. In conclusion, graft healing enhancement was observed in the high-porosity EPTFE
grafts wrapped by the omentum. It is thus suggested that transmural cellular migration plays an important role in the process
of graft healing. 相似文献
10.
Qiyong Gong Paola Dazzan Cristina Scarpazza Kyioto Kasai Xinyu Hu Tiago R. Marques Norichika Iwashiro Xiaoqi Huang Robin M. Murray Shinsuke Koike Anthony S. David Hidenori Yamasue Su Lui Andrea Mechelli 《Schizophrenia bulletin》2015,41(6):1266-1275
Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Resonance Imaging to investigate neuroanatomy in 126 patients with first episode schizophrenia who came from 4 ethnically distinct cohorts (White Caucasians, African-Caribbeans, Japanese, and Chinese). Each patient was individually matched with a healthy control of the same ethnicity, gender, and age (±1 year). We report a reduction in the gray matter volume of the right anterior insula in patients relative to controls (P < .05 corrected); this reduction was detected in all 4 ethnic groups despite differences in psychopathology, exposure to antipsychotic medication and image acquisition sequence. This finding provides evidence for a neuroanatomical signature of schizophrenia expressed above and beyond ethnic variations in incidence and clinical expression. In light of the existing literature, implicating the right anterior insula in bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety, we speculate that the neuroanatomical deficit reported here may represent a transdiagnostic feature of Axis I disorders.Key words: schizophrenia, neuroanatomy, ethnicity, magnetic resonance imaging, voxel-based morphometrySchizophrenia is common, severely disabling, and has major socioeconomic impact. Consistent with the current understanding of illness as a collection of heterogeneous clinical syndromes,1,2 epidemiological studies have found that the incidence and clinical expression of schizophrenia vary according to a number of sociodemographic factors including, amongst others, the ethnic origin of the patients under investigation.3–7 For example, patients from Asian ethnicities are more likely to experience visual hallucinations, whereas patients from western cultures and Caucasian ethnicities are more likely to suffer from auditory hallucinations.5 In addition, the content of hallucination and delusions is also strongly influenced by the patient’s ethnic milieus.5 Even within the same geographical area, ethnic origin has been found to strongly influence the incidence and manifestation of the disease. For example, African-Caribbeans living in London are more likely to develop schizophrenia6 and suffer from affective symptoms7 than White Caucasians from the same neighbourhood. Likewise, Mâori people in New Zealand are more likely to present with hallucinations and aggression and less likely to present with depression and self-harm than non-Mâori people from the same area.8
Over the past 2 decades, neuroimaging techniques have enabled greater understanding of the neuroanatomical basis of this illness.9–14 So far, however, the impact of ethnic characteristics on the neuroanatomical basis of schizophrenia has received minimal attention in the existing literature.15 Some neuroimaging studies have recruited ethnically uniform cohorts in order to minimize individual variation within each experimental group16,17; whereas other studies have included participants from a range of ethnic backgrounds based on the assumption that this would not have a significant impact on the results.10,18 Thus, at present, we know very little about whether patients from different ethnicities are characterised by similar or different neuroanatomical deficits. Here, we addressed this question by investigating 4 ethnically distinct samples comprising of (1) White Caucasian, (2) African-Caribbean, (3) Japanese, and (4) Chinese participants. The 4 groups were uniform with respect to the stage of the illness, as all patients had experienced a first episode of schizophrenia within the previous 24 months. In addition, in all 4 groups, each patient was individually matched with a healthy control of the same ethnicity, gender, and age (±1 year) in order to minimize the potential impact of these demographic variables. As the 4 groups were scanned at different sites using different scanners and acquisition sequences (see supplementary table S1 for detail), any discrepancy between datasets could be due to methodological differences. For the purpose of the present investigation, therefore, we focussed on differences between patients and controls that were expressed consistently across the 4 groups. As we preprocessed and analysed each dataset independently, using ethnic-specific templates, our investigation can be thought of as a series of replication studies across 4 independent datasets. We hypothesised that the 4 groups would show consistent neuroanatomical reductions in specific prefrontal, parietal, and limbic regions that are implicated in existing animal19 and human11,20–24 models of schizophrenia. This would provide evidence for a neuroanatomical signature of schizophrenia expressed above and beyond ethnic differences in incidence and clinical expression. 相似文献