排序方式: 共有20条查询结果,搜索用时 15 毫秒
1.
Alma Ghirelli MD Nirubol Tosakulwong BS Stephen D. Weigand MS Heather M. Clark PhD Farwa Ali MD Hugo Botha MD Joseph R. Duffy PhD Rene L. Utianski PhD Marina Buciuc MD Melissa E. Murray PhD Sydney A. Labuzan MS Anthony J. Spychalla BS Nha Trang Thu Pham BS Christopher G. Schwarz PhD Matthew L. Senjem MS Mary M. Machulda PhD Matthew Baker BS Rosa Rademakers PhD Massimo Filippi MD Clifford R. Jack Jr MD Val J. Lowe MD Joseph E. Parisi MD Dennis W. Dickson MD Keith A. Josephs MD MST MSc Jennifer L. Whitwell PhD 《Annals of neurology》2020,88(5):1009-1022
2.
3.
TAR DNA‐binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features
下载免费PDF全文
![点击此处可从《Annals of neurology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Keith A. Josephs MD MST MSc Jennifer L. Whitwell PhD Nirubol Tosakulwong BS Stephen D. Weigand MS Melissa E. Murray PhD Amanda M. Liesinger MS Leonard Petrucelli PhD Matthew L. Senjem MS Robert J. Ivnik PhD Joseph E. Parisi MD Ronald C. Petersen MD PhD Dennis W. Dickson MD 《Annals of neurology》2015,78(5):697-709
4.
5.
Keith A. Josephs Jennifer L. Whitwell Stephen D. Weigand Melissa E. Murray Nirubol Tosakulwong Amanda M. Liesinger Leonard Petrucelli Matthew L. Senjem David S. Knopman Bradley F. Boeve Robert J. Ivnik Glenn E. Smith Clifford R. Jack Jr. Joseph E. Parisi Ronald C. Petersen Dennis W. Dickson 《Acta neuropathologica》2014,127(6):811-824
The aim of this study was to determine whether the TAR DNA-binding protein of 43 kDa (TDP-43) has any independent effect on the clinical and neuroimaging features typically ascribed to Alzheimer’s disease (AD) pathology, and whether TDP-43 pathology could help shed light on the phenomenon of resilient cognition in AD. Three-hundred and forty-two subjects pathologically diagnosed with AD were screened for the presence, burden and distribution of TDP-43. All had been classified as cognitively impaired or normal, prior to death. Atlas-based parcellation and voxel-based morphometry were used to assess regional atrophy on MRI. Regression models controlling for age at death, apolipoprotein ε4 and other AD-related pathologies were utilized to explore associations between TDP-43 and cognition or brain atrophy, stratified by Braak stage. In addition, we determined whether the effects of TDP-43 were mediated by hippocampal sclerosis. One-hundred and ninety-five (57 %) cases were TDP-positive. After accounting for age, apolipoprotein ε4 and other pathologies, TDP-43 had a strong effect on cognition, memory loss and medial temporal atrophy in AD. These effects were not mediated by hippocampal sclerosis. TDP-positive subjects were 10× more likely to be cognitively impaired at death compared to TDP-negative subjects. Greater cognitive impairment and medial temporal atrophy were associated with greater TDP-43 burden and more extensive TDP-43 distribution. TDP-43 is an important factor in the manifestation of the clinico-imaging features of AD. TDP-43 also appears to be able to overpower what has been termed resilient brain aging. TDP-43 therefore should be considered a potential therapeutic target for the treatment of AD. 相似文献
6.
Qin Chen Bradley F. Boeve Nirubol Tosakulwong Timothy Lesnick Danielle Brushaber Christina Dheel Julie Fields Leah Forsberg Ralitza Gavrilova Debra Gearhart Dana Haley Jeffrey L. Gunter Jonathan Graff‐Radford David Jones David Knopman Neill Graff‐Radford Ruth Kraft Maria Lapid Rosa Rademakers Zbigniew K. Wszolek Howie Rosen Adam L. Boxer Kejal Kantarci 《Journal of neuroimaging》2019,29(5):624-629
7.
Edwards AO Chen D Fridley BL James KM Wu Y Abecasis G Swaroop A Othman M Branham K Iyengar SK Sivakumaran TA Klein R Klein BE Tosakulwong N 《Investigative ophthalmology & visual science》2008,49(4):1652-1659
PURPOSE: Evidence from genetic-association studies in conjunction with the demonstration of complement deposition in the retina and choroid implicates noncellular pathways of innate immunity in the pathogenesis of age-related macular degeneration (AMD). The purpose of this study was to determine whether common variation in the 10 human toll-like receptors (TLRs) alters the risk of AMD. METHODS: Sixty-eight SNPs were iteratively genotyped across the TLR genes in a cohort of 577 subjects, with and without AMD. Two additional cohorts were used for replication studies. Standard genetic-association methods were used to analyze the results for association with disease and interaction with other loci. RESULTS: Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing. For both SNPs, the association with AMD arose due to an excess of heterozygotes compared with homozygotes for the major allele. The two coding SNPs were not associated with AMD in another case-control cohort or an extended-family cohort. Although an intronic SNP in TLR4 was associated marginally with AMD (P = 0.03), it was not possible to replicate a previous association with the rare coding SNP D299G in this gene (P = 0.6). CONCLUSIONS: Although borderline support for association between polymorphisms in TLR genes and AMD was reported for some cohorts, these initial observations of coding SNPs in TLR3, TLR4, and TLR7 were not replicated. TLR variants are unlikely to have a major impact on overall AMD risk, and the common variants studied were not associated with AMD. 相似文献
8.
Heather M. Clark PhD Nirubol Tosakulwong BS Stephen D. Weigand MS Farwa Ali MD Hugo Botha MD Nha Trang Thu Pham BS Christopher G. Schwarz PhD Robert I. Reid PhD Matthew L. Senjem MS Clifford R. Jack Jr MD Val J. Lowe MD J. Eric Ahlskog MD PhD Keith A. Josephs MD MST MSc Jennifer L. Whitwell PhD 《Movement disorders》2021,36(11):2669-2675
9.
Jonathan Graff-Radford Bradley F. Boeve Melissa E. Murray Tanis J. Ferman Nirubol Tosakulwong Timothy G. Lesnick Mandie Maroney-Smith Matthew L. Senjem Jeffrey Gunter Glenn E. Smith David S. Knopman Clifford R. Jack Jr. Dennis W. Dickson Ronald C. Petersen Kejal Kantarci 《Neurobiology of aging》2014
Magnetic resonance spectroscopy (MRS) characteristics of dementia with Lewy bodies (DLB) Alzheimer's disease (AD) and cognitively normal controls were compared. DLB (n = 34), AD (n = 35), and cognitively normal controls (n = 148) participated in a MRS study from frontal, posterior cingulate, and occipital voxels. We investigated DLB patients with preserved hippocampal volumes to determine the MRS changes in DLB with low probability of overlapping AD pathology. DLB patients were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) in the occipital voxel. AD patients were characterized by lower NAA/Cr in the frontal and posterior cingulate voxels. Normal NAA/Cr levels in the frontal voxel differentiated DLB patients with preserved hippocampal volumes from AD patients. DLB and AD patients had elevated choline/creatine, and myo-Inositol/creatine in the posterior cingulate. MRS abnormalities associated with loss of neuronal integrity localized to the occipital lobes in DLB, and the posterior cingulate gyri and frontal lobes in AD. This pattern of MRS abnormalities may have a role in differential diagnosis of DLB and in distinguishing DLB patients with overlapping AD pathology. 相似文献
10.
Lidia Sarro Nirubol Tosakulwong Christopher G. Schwarz Jonathan Graff-Radford Scott A. Przybelski Timothy G. Lesnick Samantha M. Zuk Robert I. Reid Mekala R. Raman Bradley F. Boeve Tanis J. Ferman David S. Knopman Giancarlo Comi Massimo Filippi Melissa E. Murray Joseph E. Parisi Dennis W. Dickson Ronald C. Petersen Kejal Kantarci 《Alzheimer's & dementia》2017,13(3):257-266