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排序方式: 共有90条查询结果,搜索用时 15 毫秒
1.
Nayla Chidiac 《Annales médico-psychologiques》2021,179(3):253-256
Bartleby, by Melville, a pale character who by his strange formula, unleashes passions within and outside the novel. From literature to psychoanalysis via philosophy and psychiatry, the author will go through the various attempts to shed light on this enigmatic passion. 相似文献
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Eva Petkova Feihan Lu Joshua Kantrowitz Jamie L. Sanchez Jonathan Lehrfeld Nayla Scaramello Gail Silipo Joanna DiCostanza Marina Ross Zhe Su Daniel C. Javitt Pamela D. Butler 《Comprehensive psychiatry》2014
Schizophrenia patients exhibit impairments in auditory-based social cognition, indicated by deficits in detection of prosody, such as affective prosody and basic pitch perception. However, little is known about the psychometric properties of behavioral tests used to assess these functions. The goal of this paper is to characterize the properties of prosody and pitch perception tasks and to investigate whether they can be shortened. The pitch perception test evaluated is a tone-matching task developed by Javitt and colleagues (J-TMT). The prosody test evaluated is the auditory emotion recognition task developed by Juslin and Laukka (JL-AER). The sample includes 124 schizophrenia patients (SZ) and 131 healthy controls (HC). Properties, including facility and discrimination, of each item were assessed. Effects of item characteristics (e.g., emotion) were also evaluated. Shortened versions of the tests are proposed based on facility, discrimination, and/or ability of item characteristics to discriminate between patients and controls. Test–retest reliability is high for patients and controls for both the original and short forms of the J-TMT and JL-AER. Thus, the original as well as short forms of the J-TMT and JL-AER are suggested for inclusion in clinical trials of social cognitive and perceptual treatments. The development of short forms further increases the utility of these auditory tasks in clinical trials and clinical practice. The large SZ vs. HC differences reported here also highlight the profound nature of auditory deficits and a need for remediation. 相似文献
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Pia Zeinoun Souha Bawab Mia Atwi Nayla Hariz Lucy Tavitian Mounir Khani Ziad Nahas Fadi T. Maalouf 《Comprehensive psychiatry》2013
Background
Countries in the Arab region lack a valid Arabic psychiatric diagnostic interview for children and adolescents. We set out to establish the diagnostic validity of the Arabic version of the Development and Well Being Assessment (DAWBA-Arabic), a multi-informant structured interview for predicting DSM-IV-TR diagnoses.Methods
The DAWBA was translated, updated, and administered to 45 participants (child and adolescent psychiatric outpatients and their parents) as part of a clinic registry. Two clinicians, blinded to their respective diagnoses, formulated the DAWBA diagnoses. Participants also underwent a clinical evaluation by a child and adolescent psychiatrist who generated clinical diagnoses according to the DSM-IV-TR.Results
Inter-rater reliabilities were .93, .82, and .72 for disruptive disorders, mood disorders and anxiety disorders respectively. Agreement between DAWBA and clinical diagnoses was substantial for disruptive disorders (κ = .0.82) and mood disorders (κ = 0.74), and moderate for anxiety disorders (κ = 0.46).Conclusion
The DAWBA-Arabic could serve as a valid and reliable clinical tool for assessing psychiatric disorders among children and adolescents in the Arab region. 相似文献5.
Nayla Hariz Souha Bawab Mia Atwi Lucy Tavitian Pia Zeinoun Munir Khani Boris Birmaher Ziad Nahas Fadi T. Maalouf 《Psychiatry research》2013
This study aimed at investigating the reliability and validity of the Arabic Screen for Child Anxiety Related Emotional Disorders (SCARED) as a first child and adolescent anxiety screening tool in the Arab World. The English parent (SCARED-P) and child (SCARED-C) versions were translated into Arabic and administered along with the Arabic Strengths and Difficulties Questionnaire (SDQ) to 77 parents and 67 children attending a Psychiatry clinic. DSM-IV-TR diagnoses were made by a psychiatrist without knowledge of the scale scores. Internal consistency was confirmed by Cronbach's α=0.92 for SCARED-P and 0.91 for SCARED-C. Their subscales had internal consistencies between 0.65 and 0.89. Parent–child agreement was r=0.67, p<0.001. SCARED-P demonstrated good discriminant validity between participants with anxiety disorders and those with other psychiatric disorders (t(72)=3.13, p=0.003). For SCARED-C, this difference was significant when participants with depressive disorders were excluded (t(43)=2.58, p=0.01). Convergent validity was evident through a significant correlation between SCARED-P and the parent SDQ emotional subscale (r=0.70, p<0.001), and SCARED-C and the child SDQ emotional subscale (r=0.70, p<0.001). Divergent validity with the SDQ hyperactivity subscale was observed as no significant correlation was found. Overall, the Arabic SCARED demonstrated satisfactory psychometric properties in a clinical sample in Lebanon. 相似文献
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Christianne B.V. Scaramello Humberto Muzi-Filho Gisele Zapata-Sudo Roberto T. Sudo Valéria do M.N. Cunha 《Journal of pharmacological sciences》2009,109(2):185-192
The immunophilin 12-kDa FK506 binding protein (FKBP12) stabilizes intracellular Ca2+ release channel (CRC) activity in different tissues. In this work, the presence of FKBP12 in rat vas deferens (RVD) and its possible contribution to RVD function was investigated. Treatment under appropriate pH, temperature, and ionic conditions was used to strip FKBP12 from CRC binding sites; Western blotting revealed FKBP12 in control but not in treated homogenates. Disruption of the FKBP12-CRC complex in RVD decreased the Ca2+ content of sarcoplasmic reticulum (SR) by increasing Ca2+ leakage through the ryanodine receptor (RyR3 isoform) but not through 1,4,5-iNOSitol trisphosphate receptors (IP3R1 and IP3R3 isoforms). The decrease of SR Ca2+ content was not related to inhibition of SERCA ATPase. It seems that dissociation of FKBP12-RyR leads to conformational changes in RyR that make it difficult for ryanodine to access its binding site. Rapamycin, which is commonly used as a pharmacological tool to disrupt the FKBP12-RyR complex, decreased phenylephrine-induced contractions in RVD epididymal halves. The data suggest that FKBP12 is expressed in RVD in a labile association with RyR3. Disruption of the FKBP12-RyR3 complex may lead to modifications of RVD physiology and in consequence may compromise male fertility. 相似文献
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There is growing evidence that mini-gastric bypass (MGB) is a safe and effective procedure. Operative outcome and long-term
follow-up of a consecutive cohort of patients who underwent MGB are reported. The data on 1,000 patients who underwent MGB
from November 2005 to January 2011 at an academic institution were reviewed. Mean age was 33.15 ± 10.17 years (range, 14–72),
preoperative BMI was 42.5 ± 6.3 kg/m2 (range, 26–75), mean preoperative weight was 121.6 ± 23.8 kg (range, 71–240), and 663 were women. Operative time and length
of stay for primary vs. revisional MGB were 89 ± 12.8 min vs. 144 ± 15 min (p < 0.01) and l.85 ± 0.8 day vs. 2.35 ± 1.89 day (p < 0.01). No deaths occurred within 30 days of surgery. Short-term complications occurred in 2.7% for primary vs. 11.6% for
revisionnal MGB (p < 0.01). Five (0.5%) patients presented with leakage from the gastic tube but none had anastomotic leakage. Four (0.4%) patients,
all with revisionnal MGB, presented with severe bile reflux and were cured by stapling the afferent loop and by a latero-lateral
jejunojejunostomy. Excessive weight loss occurred in four patients; two were reversed and two were converted to sleeve gastrectomy.
Maximal percent excess weight loss (EWL) of 72.5% occurred at 18 months. Weight regain subsequently occurred with a mean variation
of −3.9% EWL at 60 months. The 50% EWL was achieved for 95% of patients at 18 months and for 89.8% at 60 months. MGB is an
effective, relatively low-risk, and low-failure bariatric procedure. In addition, it can be easily revised, converted, or
reversed. 相似文献