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European Child & Adolescent Psychiatry - The current study aims to investigate the effect of cumulative exposure to violence on mental health amongst children and adolescents living in the Gaza... 相似文献
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Background
The aim of this study was to investigate the effect of exposure to war-traumatic events on mental health in children and adolescents in the presence of other stressors such as stressful life events, exposure to traumatic events (not related to war trauma; eg, being in a car accident or having a serious illness), and poverty.Methods
Participants were chosen from the Gaza Strip using a stratified random sampling method. The data were collected in October, 2013, 1 year after the Gaza War on Nov 14–26, 2012. War-traumatic events were measured using the War-Traumatic Events Checklist (W-TECh), which includes three categories: personal trauma; witnessing trauma to others; and seeing demolition of property. Stressful life events were measured using the Stressful Life Events Scale. Exposure to traumatic events (not related to war-trauma) was measured using the University of California at Los Angeles post-traumatic stress disorder (PTSD) reaction index for the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV (child version). PTSD was measured using the PTSD Symptoms Scale. Finally, depression was measured using the Child Depression Inventory.Findings
The sample consisted of 1029 students aged 11–17 years. 496 (48%) participants were boys, and 533 (52%) participants were girls. 909 (88%) students had experienced personal trauma, 861 (84%) had witnessed trauma to others, and 908 (88%) had seen demolition of property during the war. Boys reported more exposure to personal trauma, witnessing trauma to others, seeing demolition of property, and overall traumatic events compared to girls. Girls reported more exposure to stressful life events, exposure to trauma (not related to war-trauma), PTSD, and depression. 549 (54%) students had a diagnosis of PTSD diagnosis. We found a positive correlation between the age and exposure to war-traumatic events and stressful life events and between family size and exposure to war-traumatic events and PTSD. By contrast, we found a negative correlation between family income and stressful life events, exposure to traumatic events not related to war trauma, PTSD, and depression. Finally, exposure to war-traumatic events, experience of stressful life events, and exposure to traumatic events not related to war-trauma were positively correlated with PTSD and depression.Interpretation
Socioeconomic status such as big family size and low family income increased the severity of effects of stressful life events, exposure to war-traumatic events, and exposure to traumatic events not related to war-trauma. Consequently, the possibility of PTSD and depression was high. The findings also show that stressful life events, exposure to war-trauma, and exposure to traumatic events not related to war-trauma could be considered as risk factors for PTSD and depression.Funding
Qatar National Research Fund (QNRF), a member of Qatar Foundation Doha, Qatar, National Priority Research Programs under grant NPRP 7-154-3-034 to MS. 相似文献3.
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Amjad F. Nuseir Mohammad Alsalem Mouhamad Alzahr Muthanna Ababneh Ahmad I. Alomari Firas Alzoubi 《American journal of otolaryngology》2017,38(2):135-138
Rationale and objectives
Adhesions are the most common complication after nasal surgery and revision. 5-Fluorouracil (5-FU) reduces various adhesions and epithelial growth related complications. The aim of this study was to evaluate the effects of 5-flurouracil application in the nasal cavity after a multi-procedure nasal surgery in term of complications frequency.Materials and methodology
Institutional ethical approval was granted and a double-blinded prospective clinical trial was conducted to study the effect of 5-fu on post-operative complications. At the end of a combined endoscopic inferior turbinoplasty with one or more other nasal surgeries, 5-flurouracil-soaked cottonoid with 1 mL of 5-flurouracil (5 mg/mL) was applied in one side of nasal cavity and saline-soaked cottonoid was applied contralaterally and left for 5 min. Patients were assessed over 2 months postoperatively by a blinded observer in terms of adhesions, crustation, discharge, pain, discharge, loss of smell and other complications and nasal symptoms.Results
On the 1st follow up week postoperatively, adhesions were observed in (24 patients) 35%, bilateral in (6 patients) 9% and unilateral in (18 patients) 26%. Unilateral Adhesions were statistically significantly higher in control sides than those in 5-FU sides (22% vs 4% respectively) (p = 0.025). Crustation, continued to statistically significantly diminish over time (p = 0.035). On the 8th follow up week, adhesions reduction was still statistical significant at the 5-FU treated side (p = 0.01).Conclusion
5-FU is safe and effective in preventing adhesions formation when applied during combined endoscopic inferior turbinoplasty procedure with other nasal procedure surgery. 相似文献5.
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Fares Mohammed Saeed Muthanna Mahmathi Karuppannan Bassam Abdul Rasool Hassan Ali Haider Mohammed 《Osong Public Health and Research Perspectives》2021,12(2):115
ObjectivesFatigue is the most frequently reported symptom experienced by cancer patients and has a profound effect on their quality of life (QOL). The study aimed to determine the impact of fatigue on QOL among breast cancer patients receiving chemotherapy and to identify the risk factors associated with severe fatigue incidence.MethodsThis was an observational prospective study carried out at multiple centers. In total, 172 breast cancer patients were included. The Functional Assessment of Chronic Illness Therapy-Fatigue Questionnaire was used to measure QOL, while the Brief Fatigue Inventory (BFI) was used to assess the severity of fatigue.ResultsThe total average mean and standard deviation of QOL were 84.58±18.07 and 4.65±1.14 for BFI scores, respectively. A significant association between fatigue and QOL was found in linear and multiple regression analyses. The relationships between fatigue severity and cancer stage, chemotherapy dose delay, dose reduction, chemotherapy regimen, and ethnicity were determined using binary logistic regression analysis.ConclusionThe findings of this study are believed to be useful for helping oncologists effectively evaluate, monitor, and treat fatigue related to QOL changes. 相似文献
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Mun Fei Yam Lee Fung Ang Chung Pin Lim Omar Ziad Ameer Ibrahim Muhammad Salman Mariam Ahmad Mahfoudh Al-musli Mohammed Mohd. Zaini Asmawi Muthanna Fawzy Abdulkarim Ghassan Zuhair Abdullah 《Journal of acupuncture and meridian studies》2010,3(3):197-202
Murdannia bracteata (C. B. Clarke) is a local plant that is widely used in Malaysia as a traditional remedy for various diseases of the kidney and liver, including inflammation and cancer. In the present study, we investigated the antioxidant and hepatoprotective activities of M. bracteata methanol extract (MB). 2,2′-diphenyl-1-picrylhydrazyl radical scavenging activity, lipid peroxidation inhibition and trolox equivalent antioxidant capacity of MB were determined. The hepatoprotective activity of MB was studied using a CCl4-induced liver toxicity model in rats. The hepatoprotective effect was assessed by monitoring the plasma malondialdehyde level and serum alanine transaminase and aspartate transaminase activities. Histopathological changes of hepatic tissue were also investigated. The results indicated that MB possessed potential antioxidant, lipid peroxidation inhibition and free radical scavenging activities. Pretreatment of rats with MB (500 mg/kg and 1000 mg/kg per os) before induction of CCl4-induced hepatotoxicity showed a dose-dependent reduction in the necrotic changes in hepatic tissue. The increases in plasma malondialdehyde level, serum alanine transaminase and aspartate transaminase activities were also significantly inhibited by MB. The total phenolic content of MB determined using Folin-Ciocalteu assay was found to be 10%. The results of the present study indicated that the hepatoprotective effect of MB is most likely due to its antioxidant and free radical scavenging properties. 相似文献
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Ameer OZ Salman IM Najim HS Abdullah GZ Abdulkarim MF Yam MF Sadikun A Asmawi MZ 《Journal of acupuncture and meridian studies》2010,3(4):272-282
The mode by which Loranthus ferrugineus methanol extract antagonizes and/or modulates norepinephrine-induced vasoconstriction was investigated in rat aortic rings. The vascular effects of three different concentrations of this extract were challenged against cumulative additions of norepinephrine. Phentolamine, a nonselective α-adrenoceptor antagonist, verapamil, an L-type calcium channel blocker, and papaverine, a phosphodiesterase inhibitor, were used in three different concentrations as positive controls. Log concentration-response curves and double-reciprocal plots were constructed for the extract and each vasorelaxant. To characterize antagonism reversibility, the norepinephrine maximum contractile effect was examined before extract addition to the aortic ring chamber and after its removal. Phentolamine shifted the norepinephrine log concentration-response curve to the right with no significant depression in the maximum response. Similar to verapamil and papaverine, the extract produced a rightward shift in norepinephrine log concentration-response curve and a significant drop in maximum response. The double-reciprocal plots showed comparable y-intercept values for all phentolamine concentrations, a characteristic of competitive antagonism. In contrast, different y-intercept values on double-reciprocal plots were obtained for each concentration of extract, verapamil, and papaverine, typical of noncompetitive antagonism. The norepinephrine maximum contractile response was approximately similar before the addition of extract and after its removal. The data collectively showed that L. ferrugineus methanol extract exerted its vascular effect by reversible noncompetitive antagonism of norepinephrine-induced vasoconstriction. These findings add to the understanding of the cardiovascular mechanisms by which L. ferrugineus, a plant traditionally used for the management of hypertension, elicits its action. 相似文献
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