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1.
Mhawech P Berczy M Assaly M Herrmann F Bouzourene H Allal AS Dulguerov P Schwaller J 《American journal of clinical pathology》2004,122(1):100-105
Distinction of high-grade esthesioneuroblastomas from other poorly differentiated tumors arising in the nasal cavity is an important diagnostic challenge because it determines patient management and prognosis. The human achaete-scute homologue (hASH1) gene is critical in olfactory neuronal differentiation and is expressed in immature olfactory cells; therefore, it could have potential use as a diagnostic marker The aim of the present study was to determine the value of hASH1 messenger RNA (mRNA) levels in differentiating esthesioneuroblastoma from other poorly differentiated tumors. A real-time polymerase chain reaction assay was developed, permitting the comparative determination of hASH1 mRNA levels in triplicate in a double-blind pilot study including 24 frozen cases of esthesioneuroblastoma and poorly differentiated tumors. All 4 positive cases were esthesioneuroblastomas, and all 19 poorly differentiated tumors were negative. In addition, there was an inverse association between the grade of esthesioneuroblastomas and hASH1 mRNA levels. The hASH1 mRNA level might represent a useful tool for distinguishing esthesioneuroblastoma from poorly differentiated tumors of the sinonasal region. 相似文献
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Siproudhis L Eléouet M Rousselle A El Alaoui M Ropert A Bretagne JF 《Diseases of the colon and rectum》2008,51(9):1356-1360
PURPOSE Rectal prolapse is frequently associated with fecal incontinence; however, the relationship is questionable. The study was
designed to evaluate fecal incontinence in a large consecutive series of patients who suffered from rectal prolapse, focusing
on both past history, anal physiology, and imaging.
METHODS Eighty-eight consecutive patients who suffered from an overt rectal prolapse (72 women, 16 men; mean age, 51.1 ± 19.5 years)
as a main symptom were analyzed; 48 patients also experienced fecal incontinence compared with 40 without incontinence. Logistic
regression analyses were performed.
RESULTS The two groups of patients did not differ with respect to parity, weekly stool frequency, main duration of symptoms before
referral, occurrence of dyschezia, and digital help to defecate. Patients with prolapse who were older than 45 years (odds
ratio (OR), 4.51 (1.49–13.62); P = 0.007) and those with a past history of hemorrhoidectomy (OR, 9.05 (1.68–48.8); P = 0.01) were significantly more incontinent. Incontinent group showed frequent internal anal sphincter defect compared with
the continent group (60 vs. 6.2 percent; P = 0.0018).
CONCLUSIONS In patients with overt rectal prolapse, the occurrence of fecal incontinence needs special consideration for age and previous
hemorrhoid surgery as causative factors. Anal weakness and sphincter defects are frequently observed. 相似文献
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Ruben Pea Zavala Mounia Marzouki Mona Beaunoyer Fernando Alvarez 《Pediatric transplantation》2020,24(6)
Most children with hepatoblastoma manifest, at the time of LT, a decrease in renal function due to chemotherapy that could be further deteriorated by the use of calcineurin inhibitors. The purpose of this work was to examine the long‐term follow‐up of renal function in a cohort of children transplanted for unresectable hepatoblastoma. We present a retrospective observational study of 10 pediatric patients who received a LT for unresectable hepatoblastoma between 1996 and 2016. All patients included in this study were followed up on a regular basis and were assessed for GFR before transplantation and at least once a year during follow‐up. All patients received standardized chemotherapy treatment for hepatoblastoma and immunosuppression according to hospital protocols. There was a marked decrease in GFR at the time of the LT in five patients presenting renal complications during the pretransplant cycles of chemotherapy. Three patients, one of them with prior kidney involvement, presented complications after LT, namely acute kidney failure and decrease in GFR. Those patients who presented with the lowest GFR at the time of LT eventually recovered renal function at levels similar to the rest of the group on follow‐up. Chemotherapy‐induced nephrotoxicity is a concern in patients treated for hepatoblastoma. Some individuals will develop low GFR after chemotherapy; therefore, strict follow‐up is recommended, as low GFR may affect the doses of subsequent chemotherapy and immunosuppression. Stabilization of GFR levels and occasional improvement can be observed in the post‐transplant period. 相似文献
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Indeterminate genotypes of hepatitis C virus by the Abbott RealTime HCV Genotype II assay in Morocco. About eight cases resolved by a sequencing method 下载免费PDF全文
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Mounia Amarouayache Farid Derbal M. Hichem Kara 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2009,54(4):330-334
Studies revealed the role of Artemia salina as intermediate host in the life-cycle of a cestode species parasitizing flamingos, i.e. Flamingolepis liguloides. Cysticercoids of this parasite were found for the first time in the Algerian populations of Artemia salina in winter of 2000 and 2001 in Chott Marouane and spring of 2003 in Sebkha Ez-Zemoul. The prevalence ranged between 10 and
33% for the two examined Artemia populations. The intensity of infection was 1–3 cysticercoids per individual. The abdomen was the most targeted site of infection
(95% of the population of Sebkha Ez-Zemoul) followed by the thorax and the ovisac. Infected females were less fertile than
uninfected ones (24.83 vs 43.70 cysts/brood) in Sebkha Ez-Zemoul or castrated in Chott Marouane. 相似文献