全文获取类型
收费全文 | 1284篇 |
免费 | 75篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 68篇 |
妇产科学 | 71篇 |
基础医学 | 207篇 |
口腔科学 | 19篇 |
临床医学 | 55篇 |
内科学 | 374篇 |
皮肤病学 | 21篇 |
神经病学 | 63篇 |
特种医学 | 49篇 |
外科学 | 199篇 |
综合类 | 9篇 |
预防医学 | 27篇 |
眼科学 | 5篇 |
药学 | 56篇 |
中国医学 | 1篇 |
肿瘤学 | 141篇 |
出版年
2023年 | 11篇 |
2022年 | 20篇 |
2021年 | 33篇 |
2020年 | 19篇 |
2019年 | 36篇 |
2018年 | 27篇 |
2017年 | 29篇 |
2016年 | 27篇 |
2015年 | 32篇 |
2014年 | 68篇 |
2013年 | 77篇 |
2012年 | 97篇 |
2011年 | 111篇 |
2010年 | 51篇 |
2009年 | 38篇 |
2008年 | 69篇 |
2007年 | 68篇 |
2006年 | 73篇 |
2005年 | 62篇 |
2004年 | 72篇 |
2003年 | 77篇 |
2002年 | 68篇 |
2001年 | 13篇 |
2000年 | 15篇 |
1999年 | 17篇 |
1998年 | 15篇 |
1997年 | 14篇 |
1996年 | 14篇 |
1995年 | 14篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 8篇 |
1991年 | 11篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 4篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1966年 | 2篇 |
排序方式: 共有1368条查询结果,搜索用时 15 毫秒
1.
ASTROCYTE-CONDITIONED MEDIUM INDUCES BLOOD-BRAIN BARRIER PROPERTIES IN ENDOTHELIAL CELLS 总被引:6,自引:0,他引:6
2.
Isao Sekiguchi M.D. Mitsuaki Suzuki M.D. Ikuo Sato M.D. Taeko Ohkawa M.D. Hidetoshi Kawashima M.D. Syuichi Tsuchida M.D. 《Gynecologic oncology》1998,71(3):454-457
We present the fourth known case of endometrial carcinoma, and the second case of endometrial small-cell carcinoma, to be associated with paraneoplastic retinopathy. Initial symptoms were decreased visual acuity and a narrowing of the visual field. Endometrial carcinoma was diagnosed several months later. An antibody to 34-kDa bovine retinal antigen was detected in the patient's serum. Thus, autoimmunity was suspected as the cause of the retinopathy. In patients with endometrial carcinoma with visual disturbance of unknown cause, paraneoplastic retinopathy should be suspected. 相似文献
3.
4.
5.
Identification of a Rough Strain of Escherichia coli O157:H7 That Produces No Detectable O157 Antigen
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Peter Feng Robin C. Sandlin Choong H. Park Richard A. Wilson Mitsuaki Nishibuchi 《Journal of clinical microbiology》1998,36(8):2339-2341
MA6, an O157:H7-like strain, did not react with most anti-O157 kits examined; however, it had the rfbE gene that is essential for O157 expression and carried O157:H7 virulence factors. Lipopolysaccharide analysis showed that MA6 is a rough strain that does not produce the O157 antigen, but genetically, it belongs in the O157:H7 clonal group. 相似文献
6.
Hirata I Hioki Y Toda M Kitazawa T Murakami Y Kitano E Kitamura H Ikada Y Iwata H 《Journal of biomedical materials research. Part A》2003,66(3):669-676
Since complement activation is recognized as a common response of the host defense system when an artificial medical device is applied to a patient, great effort has been devoted to studies on the interaction of the complement system with artificial materials. However, some uncertainties remain, partially because of the lack of well characterized surfaces and suitable analytic methods for study of the surface phenomena that occur on artificial materials under physiologic conditions. In this study, we employed self-assembled monolayers (SAMs) and the surface plasmon resonance (SPR) technique to study interactions of the serum complement with well characterized surfaces. Self-assembled monolayers carrying various concentrations of hydroxyl groups were prepared using 11-mercapto-1-undecanol (C11-OH) and one of n-nonanethiol, n-dodecanethiol, and n-hexadecanethiol. The amount of NHS deposition on the SAMs increased with increasing C11-OH content of the SAMs, and the amount of anti-C3b antibody immobilization formed on the NHS deposition layers increased with increasing C11-OH content of the SAMs. These results clearly demonstrate that a large amount of C3b, produced through the activation of the complement system, binds covalently to and is adsorbed by hydroxyl-group-rich surfaces. The combination of SAMs and the SPR technique is suitable for studying the interaction of the complement system with solid surfaces, and the results should give basic information needed for a rational design of biocompatible surfaces on synthetic materials. 相似文献
7.
Saheki T Kobayashi K Iijima M Horiuchi M Begum L Jalil MA Li MX Lu YB Ushikai M Tabata A Moriyama M Hsiao KJ Yang Y 《Molecular genetics and metabolism》2004,81(Z1):S20-S26
Citrin is a mitochondrial aspartate glutamate carrier primarily expressed in the liver, heart, and kidney. We found that adult-onset type II citrullinemia is caused by mutations in the SLC25A13 gene that encodes for citrin. In this report, we describe the frequency of SLC25A13 mutations, the roles of citrin as a member of the urea cycle and as a member of the malate-aspartate shuttle, the relationship between its functions and symptoms of citrin deficiency, and therapeutic issues. 相似文献
8.
Kanagawa phenomenon-positive strains of Vibrio parahaemolyticus contain two copies of the tdh gene (tdh1 and tdh2) encoding thermostable direct hemolysin (TDH). Previous studies suggested that the tdh2 gene, but not the tdh1 gene, was responsible for production of extracellular TDH. In this study, a tdh2-deficient isogenic mutant of Kanagawa phenomenon-positive strain AQ3815 was constructed by a suicide vector-mediated in vivo recombination method. The intact tdh1 gene in the mutant contributed little to Kanagawa phenomenon on Wagatsuma agar but produced TDH in broth media, accounting for 0.5–9.4% of total extracellular TDH of AQ3815. 相似文献
9.
10.
Kentaro Ariyoshi Yota Hiroyama Naoya Fujiwara Tomisato Miura Kosuke Kasai Akifumi Nakata Yohei Fujishima Valerie Swee Ting Goh Mitsuaki A Yoshida 《Journal of radiation research》2021,62(1):73
Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation. 相似文献