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排序方式: 共有176条查询结果,搜索用时 15 毫秒
1.
Terue Suzuki Masatoyo Kagoshima Masahiro Shibata Niro Inaba Sadayoshi Onodera Tetsuaki Yamaura Hideyo Shimada 《Digestive diseases and sciences》1997,42(6):1242-1254
The effect of chemical deafferentation, vagotomy(VGX), and gangliosympathectomy (GSX) on the density offibers containing calcitonin gene-related peptide (CGRP)and substance P (Sub.P) in the rat gastric wall was studied. Chemical deafferentation bycapsaicin abolished the density of CGRP-immunoreactive(IR) fibers, not Sub.P-IR fibers. Ten days after VGX,the density of CGRP-IR or Sub.P-IR fibers in the mucosa was largely reduced, while no reductionof CGRP-IR and Sub.P-IR fibers was seen in submucosaland muscular layers. GSX significantly reduced thedensity of CGRP-IR fibers in the mucosa and caused a moderate decrease in the fibers in submucosaland muscular layers. Pretreatment with6-hydroxydopamine, a neurotoxin for noradrenergicnerves, did not affect the density of CGRP-IR fibers inthe gastric wall. The density of Sub.P-IR fibers in thegastric wall was not affected by GSX. These studiesindicate that the CGRP-IR and Sub.P-IR fibers in themucosa are susceptible to extrinsic nerve denervation compared with those in the submucosa and musclelayers, that a major portion of the CGRP-IR fibers inthe mucosa is of both vagal and spinal origin, and thata major portion of the Sub.P-IR fibers in the mucosa is of vagal origin. Furthermore, thepresent results support that CGRP-IR fibers, notSub.P-IR fibers, in the rat stomach arecapsaicin-sensitive. 相似文献
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Saito Masaya Saito Ayano Abe Fumito Imaizumi Chihiro Kaga Hajime Sawamura Masato Nara Mizuho Ozawa Masatoyo Sato Ryuta Nakayama Takahiro Okuyama Shin Masai Rie Ohtani Hiroshi Komatsuda Atsushi Wakui Hideki Takahashi Naoto 《Clinical and experimental nephrology》2022,26(8):760-769
Clinical and Experimental Nephrology - We determined the usefulness and prognostic ability of the renal risk score (RRS), proposed in Europe, for Japanese patients with antineutrophil cytoplasmic... 相似文献
4.
Haruka Ouchi MD Yasuko Toyoshima MD PhD Mari Tada MD PhD Mutsuo Oyake MD PhD Izumi Aida MD Itsuro Tomita MD PhD Akira Satoh MD PhD Mitsuhiro Tsujihata MD PhD Hitoshi Takahashi MD PhD Masatoyo Nishizawa MD PhD Takayoshi Shimohata MD PhD 《Movement disorders》2014,29(2):238-244
The aim of this study was to investigate corticobasal syndrome with respect to underlying pathologies, the ability of current clinical criteria to detect early stages of disease, and symptoms and signs predicting background pathologies. We retrospectively analyzed the clinicopathological findings from patients with corticobasal syndrome. We also analyzed whether those findings fulfilled the diagnostic criteria for corticobasal degeneration (CBD). Finally, we investigated characteristic clinical features that are specific to each background pathology. Of 10 consecutive autopsied patients who had corticobasal syndrome (mean age ± standard deviation, 67.9 ± 9.3 years; male:female ratio, 6:4), three had corticobasal degeneration pathology, three had progressive supranuclear palsy, three had Alzheimer's disease, and one had atypical four‐repeat tauopathy. Nine patients fulfilled Mayo criteria, and all 10 patients fulfilled modified Cambridge criteria at the later stage, but only two patients fulfilled either clinical criteria within 2 years of disease onset. Five patients fulfilled the clinical criteria for possible CBD (p‐CBD), and one patient fulfilled the clinical research criteria for probable sporadic CBD (cr‐CBD) at the later stage. Only two patients fulfilled the criteria for either p‐CBD or cr‐CBD within 2 years of disease onset. Although we could not find any predictive characteristic clinical features that were specific to CBD pathology, only patients with progressive supranuclear palsy developed apraxia of eyelid opening and cerebellar ataxia. Myoclonus and memory impairment, especially if they appear at an early stage of the disease, may predict Alzheimer's disease pathology. Sensitivity of the available clinical criteria for corticobasal syndrome was poor within 2 years of disease onset. © 2013 International Parkinson and Movement Disorder Society 相似文献
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Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology 总被引:1,自引:0,他引:1
Nishihira Y Tan CF Hoshi Y Iwanaga K Yamada M Kawachi I Tsujihata M Hozumi I Morita T Onodera O Nishizawa M Kakita A Takahashi H 《Acta neuropathologica》2009,117(1):45-53
Recently, sporadic amyotrophic lateral sclerosis (SALS), a fatal neurological disease, has been shown to be a multisystem
proteinopathy of TDP-43 in which both neurons and glial cells in the central nervous system are widely affected. In general,
the natural history of SALS is short (<5 years). However, it is also known that a few patients may survive for 10 years or
more, even without artificial respiratory support (ARS). In the present study using TDP-43 immunohistochemistry, we examined
various regions of the nervous system in six patients with SALS of long duration (10–20 years) without ARS, in whom lower
motor-predominant disease with Bunina bodies and ubiquitinated inclusions (UIs) in the affected lower motor neurons was confirmed.
One case also showed UIs in the hippocampal dentate granule cells (UDG). In all cases, except one with UDG, the occurrence
of TDP-43-immunoreactive (ir) neuronal cytoplasmic inclusions (NCIs) was confined to a few regions in the spinal cord and
brainstem, including the anterior horns. In one case with UDG, TDP-43-ir NCIs were also detected in the substantia nigra,
and some regions of the cerebrum, including the hippocampal dentate gyrus (granule cells). The number of neurons displaying
NCIs in each region was very small (1–3 per region, except the dentate gyrus). On the other hand, the occurrence of TDP-43-ir
glial cytoplasmic inclusions (GCIs) was more widespread in the central nervous system, including the cerebral white matter.
Again, however, the number of glial cells displaying GCIs in each region was very small (1–3 per region). In conclusion, compared
to the usual form of SALS, TDP-43 pathology shown in SALS of long duration was apparently mild in degree and limited in distribution,
corresponding to the relatively benign clinical courses observed. It is now apparent that SALS of long duration is actually
part of a TDP-43 proteinopathy spectrum. 相似文献
7.
Tan CF Piao YS Kakita A Yamada M Takano H Tanaka M Mano A Makino K Nishizawa M Wakabayashi K Takahashi H 《Acta neuropathologica》2005,109(3):329-338
We report two patients who exhibited frontotemporal dementia (FTD) with unusual neuropathological features. The ages of the patients at death were 65 and 67 years, the disease durations were 6 and 5 years, and the clinical diagnoses were Picks disease and corticobasal degeneration (CBD), respectively. At autopsy, both cases exhibited neuropathological findings compatible with those of CBD, including atrophy of the frontal and parietal lobes, neuronal loss and gliosis in the cortical and subcortical regions, and presence of cortical ballooned neurons and astrocytic plaques (APs). In both cases, immunoblotting of insoluble tau exhibited the pattern of selective accumulation of four-repeat tau, a finding that is also compatible with CBD. However, severe degeneration was evident in the frontal and parietal white matter in both cases. Moreover, a striking finding was the widespread presence in the affected cortex of tufted astrocytes (TAs), which are characteristic of progressive supranuclear palsy (PSP). Neither co-occurrence of APs and TAs nor severe degeneration of the cerebral white matter is a feature of either CBD or PSP. No mutations were found in the tau gene in either case. In conclusion, the possibility that these two cases represent a new neuropathological phenotype of non-familial FTD rather than simply a variant of CBD cannot be completely excluded. 相似文献
8.
Quantitative evaluation of brainstem involvement in multiple system atrophy by diffusion-weighted MR imaging 总被引:1,自引:0,他引:1
Kanazawa M Shimohata T Terajima K Onodera O Tanaka K Tsuji S Okamoto K Nishizawa M 《Journal of neurology》2004,251(9):1121-1124
Abstract.
In multiple system atrophy (MSA), symptoms associated with dysfunctions of the brainstem and autonomic nervous system are important prognostic factors. We investigated brainstem involvement in 12 patients with MSA with predominant cerebellar symptoms (MSA-C) (mean age, 56.3 ± 9.9 years, median disease duration, 3 years), and 11 controls (57.6 ± 12.0 years) matched for age using diffusion-weighted MR imaging (DWI). We demonstrated that apparent diffusion coefficients (ADCs) in the pons and middle cerebellar peduncle of MSA-C patients are significantly higher than those of normal controls even though the patients are in the early stage of the disease. Furthermore, we demonstrated that increased ADC values correlated well with the disease duration. The current study demonstrated that DWI is a useful noninvasive method for the quantitative evaluation of the brainstem involvement in MSA-C patients. 相似文献
9.
Adrenal myelolipoma is a benign tumor composed of fat and bone marrow tissues and is usually found incidentally. Spontaneous retroperitoneal hemorrhage from this tumor is rare. To our knowledge, there have been only 11 reported cases of ruptured adrenal myelolipoma in the literature. We report a 37-year-old female patient who underwent transcatheter arterial embolization using gelatin sponge particles for retroperitoneal hemorrhage from adrenal myelolipoma, 8x6x6 cm in size. This case, which is the second in the literature, illustrates the usefulness of embolization to achieve hemostasis prior to subsequent tumor resection. 相似文献
10.
Mariko Hokari MD Akiko Yokoseki MD PhD Musashi Arakawa MD PhD Etsuji Saji MD PhD Kaori Yanagawa MD PhD Fumihiro Yanagimura MD Yasuko Toyoshima MD PhD Kouichirou Okamoto MD PhD Satoshi Ueki MD PhD Tetsuhisa Hatase MD PhD Riuko Ohashi MD PhD Takeo Fukuchi MD PhD Kohei Akazawa PhD Mitsunori Yamada MD PhD Akiyoshi Kakita MD PhD Hitoshi Takahashi MD PhD Masatoyo Nishizawa MD PhD Izumi Kawachi MD PhD 《Annals of neurology》2016,79(4):605-624