全文获取类型
收费全文 | 333篇 |
免费 | 13篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 5篇 |
妇产科学 | 1篇 |
基础医学 | 9篇 |
临床医学 | 23篇 |
内科学 | 42篇 |
皮肤病学 | 145篇 |
神经病学 | 25篇 |
特种医学 | 4篇 |
外科学 | 42篇 |
综合类 | 3篇 |
预防医学 | 7篇 |
药学 | 34篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 4篇 |
2020年 | 1篇 |
2019年 | 5篇 |
2018年 | 6篇 |
2017年 | 2篇 |
2016年 | 6篇 |
2015年 | 6篇 |
2014年 | 11篇 |
2013年 | 4篇 |
2012年 | 11篇 |
2011年 | 20篇 |
2010年 | 6篇 |
2009年 | 11篇 |
2008年 | 11篇 |
2007年 | 15篇 |
2006年 | 14篇 |
2005年 | 23篇 |
2004年 | 20篇 |
2003年 | 15篇 |
2002年 | 26篇 |
2001年 | 32篇 |
2000年 | 24篇 |
1999年 | 11篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 8篇 |
1989年 | 5篇 |
1988年 | 1篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1964年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有348条查询结果,搜索用时 15 毫秒
1.
A 54 year-old woman developed approximately 150 generalized glomus tumors since she had been 23 years old. Painful tumors showed more glomus cells than those being not painful. Furthermore, the patient suffered from persisting congenital capillary hemangioma (strawberry mark). Histological examination revealed that glomus cells were located in the vessel walls. The large amount of Dopa found in the glomus tumor tissue supports the assumption that it may be innervated by adrenergic efferent nerves. 相似文献
2.
We report on a 21-year-old man professionally exposed to mercury, who developed lichen planus. This case must be regarded as a dispositional reaction and is in Germany entitled to indemnification in terms of a "quasi-occupational disease". The clinical signs and the probably non-allergic pathomechanism are comparable with those of lichen planus induced by gold. In diseases due to occupational intoxication, we face an individual disposition regarding the degree of clinical symptoms, which has to underly any expert opinion on indemnity. 相似文献
3.
Development and in Vitro Evaluation of Systems to Protect Peptide Drugs from Aminopeptidase N 总被引:1,自引:0,他引:1
Purpose. Develop and evaluate systems to prevent aminopeptidase N caused enzymatic degradation of perorally administrated peptide drugs.
Methods. Bacitracin was covalently bound to the unabsorbable carrier matrix poly(acrylic acid) (paa) in order to avoid any dilution effects of the inhibitor in the intestine as well as systemic toxic side effects. The inhibitory effect of this conjugate, of neutralized paa and N-acetylcysteine was evaluated using a brush border membrane model.
Results. Whereas within 6 h of incubation 65.3 ± 3.7 mol/1 of the substrate (L-leucine p-nitroanilide) was hydrolyzed under our assay conditions, this metabolism was reduced to 44.5 ± 6.3 mol/1 and 49.0 ± 8.8 mol/1 (n = 3–5; ± S.D.) using 1.5% bacitracin-polymer conjugate and 0.5% N-acetylcysteine, respectively. The same amount of bacitracin as immobilized to the polymer exhibited a comparably weaker inhibitory effect. Neutralized paa did not inhibit membrane bound aminopeptidase N. Covering the membrane with a thin mucus layer led to a significantly lowered inhibitory effect of all tested agents.
Conclusions. The immobilization of enzyme inhibitors to a carrier matrix and the use of N-acetylcysteine as a novel inhibitor are promising strategies in order to overcome the enzymatic barrier caused by membrane bound peptidases. However the use of effective mucolytic agents seems to be a prerequisite. 相似文献
4.
5.
6.
Marisela Y. Soto-Padilla César Valenzuela-Encinas Luc Dendooven Rodolfo Marsch Pablo Gortáres-Moroyoqui 《International journal of environmental health research》2014,24(1):82-90
A wide diversity of organisms exists in soil. Well-adapted groups can be found in extreme environments. A great economic and metabolic potential for extremozymes produced by organisms living at extreme environments has been reported. Extreme characteristics such as high salt content and high pH level make the soil of the former Texcoco Lake a unique place which has not been exploited. Therefore, in this study, 66 strains from soil of the former Texcoco Lake were isolated and phylogenetically analyzed using universal oligonucleotide primers. Different genera such as Kocuria, Micrococcus, Nesterenkonia, Halomonas, Salinicoccus, Kurthia, Gracilibacillus, and Bacillus were found. However, only 22 from all isolated strains were identified at specie level. 相似文献
7.
Noninvasive central venous pressure measurement by controlled compression sonography at the forearm.
Christoph Thalhammer Markus Aschwanden Angela Odermatt Ulrich A Baumann Stephan Imfeld Deniz Bilecen Stephan C Marsch Kurt A Jaeger 《Journal of the American College of Cardiology》2007,50(16):1584-1589
OBJECTIVES: We sought to validate a new noninvasive technique to determine central venous pressure (CVP) using high-resolution compression sonography. BACKGROUND: Information concerning CVP is crucial in clinical situations, including cardiac failure, volume overload, and sepsis. The measurement of CVP, however, requires puncture of a vein with attendant risk of complication. METHODS: After a proof-of-concept study in healthy subjects, a prospective blinded evaluation was performed comparing CVP measurement using a central venous catheter with measurement using compression sonography in critically ill (intensive care unit) patients. RESULTS: In healthy subjects with experimentally induced venous hypertension with a wide range of pressure values, a strong correlation (r = 0.95; p < 0.001) between noninvasive and invasive peripheral venous pressure at the forearm was shown. High interobserver agreement with an intraclass correlation coefficient of 0.988 shows excellent reliability of the system. Noninvasive peripheral venous pressure measurement at the forearm showed a good correlation with CVP in 50 intensive care unit patients with the forearm positioned both below heart level (r = 0.84; p < 0.001) and at heart level (r = 0.85; p < 0.001). The mean difference between invasive and noninvasive measurement was negligible (-0.1 +/- 3.5 cm H2O and -0.7 +/- 3.4 cm H2O, respectively). CONCLUSIONS: Controlled-compression sonography is a valuable tool for measuring venous pressure in peripheral veins and allows reliable indirect assessment of CVP without intravenous catheterization. 相似文献
8.
Stoll Svenja Macha Kosmas Marsch Armin Gerner Stefan T. Siedler Gabriela Fröhlich Kilian Volbers Bastian Strasser Erwin F. Schwab Stefan Kallmünzer Bernd 《Journal of neurology》2020,267(7):2007-2012
Journal of Neurology - Oral Factor Xa inhibitors for the prevention of stroke in atrial fibrillation require dose adjustment based on certain clinical criteria, but the off-label use of the reduced... 相似文献
9.
10.
Acute effect of a dried ethanol-water extract of garlic on the microhaemovascular system of the skin
In the present study, the acute vasoactive effect of a dried hydrophilic extract of garlic with 600 mg active substance (Alliosan) was investigated in 10 healthy volunteers. Laser-Doppler fluxmetry, video capillary microscopy and transcutaneous partial pressure of oxygen measurements were used for the objective assessment of functional and morphological parameters. An increase in perfusion could be demonstrated by these means. This was based on an increase in erythrocyte flow velocity of up to 2 h duration, which was mainly due to vasodilation in both arterial and venous vessels. A change in transcutaneous partial pressure of oxygen or an influence on sympathetically-mediated vasomotor reflexes could not be demonstrated. Furthermore, there was no evidence of an influence on reactive hyperaemia after controlled hyperthermia. The test substance was shown to increase the cutaneous microperfusion. 相似文献