全文获取类型
收费全文 | 3107篇 |
免费 | 254篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 195篇 |
妇产科学 | 115篇 |
基础医学 | 401篇 |
口腔科学 | 61篇 |
临床医学 | 300篇 |
内科学 | 544篇 |
皮肤病学 | 50篇 |
神经病学 | 89篇 |
特种医学 | 550篇 |
外科学 | 507篇 |
综合类 | 71篇 |
预防医学 | 176篇 |
眼科学 | 25篇 |
药学 | 126篇 |
中国医学 | 3篇 |
肿瘤学 | 173篇 |
出版年
2022年 | 12篇 |
2021年 | 26篇 |
2020年 | 18篇 |
2019年 | 31篇 |
2018年 | 38篇 |
2017年 | 25篇 |
2016年 | 36篇 |
2015年 | 54篇 |
2014年 | 63篇 |
2013年 | 101篇 |
2012年 | 92篇 |
2011年 | 110篇 |
2010年 | 121篇 |
2009年 | 87篇 |
2008年 | 98篇 |
2007年 | 92篇 |
2006年 | 93篇 |
2005年 | 79篇 |
2004年 | 90篇 |
2003年 | 83篇 |
2002年 | 96篇 |
2001年 | 86篇 |
2000年 | 89篇 |
1999年 | 102篇 |
1998年 | 151篇 |
1997年 | 128篇 |
1996年 | 145篇 |
1995年 | 113篇 |
1994年 | 87篇 |
1993年 | 96篇 |
1992年 | 64篇 |
1991年 | 48篇 |
1990年 | 39篇 |
1989年 | 92篇 |
1988年 | 61篇 |
1987年 | 71篇 |
1986年 | 61篇 |
1985年 | 68篇 |
1984年 | 30篇 |
1983年 | 43篇 |
1982年 | 42篇 |
1981年 | 29篇 |
1980年 | 41篇 |
1979年 | 17篇 |
1978年 | 18篇 |
1977年 | 28篇 |
1976年 | 29篇 |
1975年 | 36篇 |
1974年 | 18篇 |
1966年 | 11篇 |
排序方式: 共有3390条查询结果,搜索用时 15 毫秒
1.
Williamson Kathleen A.; Hever Ann M.; Rainger Joe; Rogers R. Curtis; Magee Alex; Fiedler Zdenek; Keng Wee Teik; Sharkey Freddie H.; McGill Niolette; Hill Clare J.; Schneider Adele; Messina Mario; Turnpenny Peter D.; Fantes Judy A.; van Heyningen Veronica; FitzPatrick David R. 《Human molecular genetics》2006,15(12):2030
Table 1 相似文献
2.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
3.
4.
5.
Reduced blood clearance and increased urinary excretion of N-nitrosodimethylamine in patas monkeys exposed to ethanol or isopropyl alcohol. 总被引:1,自引:0,他引:1
L M Anderson R Koseniauskas E S Burak T J Moskal C T Gombar J M Phillips E B Sansone S Keimig P N Magee J M Rice 《Cancer research》1992,52(6):1463-1468
Low concentrations of N-nitrosodimethylamine are metabolized in rodent and human liver by cytochrome P450IIE1, an activity competitively inhibitable by ethanol. In rodents coadministration of ethanol with N-nitrosodimethylamine results in increased tumorigenicity in extrahepatic organs, probably as a result of reduced hepatic clearance. To test this concept in a primate, the effects of ethanol cotreatment on the pharmacokinetics of N-nitrosodimethylamine were measured in male patas monkeys. Ethanol, 1.2 g/kg given p.o. before i.v. N-nitrosodimethylamine (1 mg/kg) or concurrently with an intragastric dose resulted in a 10-50-fold increase in the area under the blood concentration versus time curves and a 4-13-fold increase in mean residence times for N-nitrosodimethylamine. Isopropyl alcohol, 3.2 g/kg 24 h before N-nitrosodimethylamine, also increased these parameters 7-10-fold; this effect was associated with persistence of isopropyl alcohol and its metabolic product acetone, both IIE1 inhibitors, in the blood. While no N-nitrosodimethylamine was detected in expired air, trace amounts were found in urine. Ethanol and isopropyl alcohol pretreatment increased the maximum urinary N-nitrosodimethylamine concentration 15-50-fold and the percentage of the dose excreted in the urine by 100-800-fold. Thus ethanol and isopropyl alcohol greatly increase systemic exposure of extrahepatic organs to N-nitrosodimethylamine in a primate. 相似文献
6.
7.
8.
9.
10.
S. J. Pelletier M. K. Guidinger R. M. Merion M. J. Englesbe R. A. Wolfe J. C. Magee H. W. Sollinger 《American journal of transplantation》2006,6(7):1646-1652
The optimal use of kidneys from small pediatric deceased donors remains undetermined. Using data from the Scientific Registry of Transplant Recipients, 2886 small (< 21 kg) pediatric donors between 1993 and 2002 were identified. Donor factors predictive of kidney recovery and transplantation (1343 en bloc; 1600 single) were identified by logistic regression. Multivariable Cox regression was used to assess the risk of graft loss. The rate of kidney recovery from small pediatric donors was significantly higher with increasing age, weight and height. The odds of transplant of recovered small donor kidneys were significantly higher with increasing age, weight, height and en bloc recovery (adjusted odds ratio = 65.8 vs. single; p < 0.0001), and significantly lower with increasing creatinine. Compared to en bloc, solitary transplants had a 78% higher risk of graft loss (p < 0.0001). En bloc transplants had a similar graft survival to ideal donors (p = 0.45) while solitary transplants had an increased risk of graft loss (p < 0.0001). En bloc recovery of kidneys from small pediatric donors may result in the highest probability of transplantation. Although limited by the retrospective nature of the study, kidneys transplanted en bloc had a similar graft survival to ideal donors but may not maximize the number of successfully transplanted recipients. 相似文献