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Thomas L. Patterson Shirley J. Semple Lydia R. Temoshok J. Hampton Atkinson J. Allen McCutchan Kristy A. Straits-Trster James L. Chandler Igor Grant 《Journal of Applied Biobehavioral Research》1993,1(1):64-87
The significance of life stress, coping, and social support was examined in relation to depressive symptomatology in a sample of 160 asymptomatic and mildly symptomatic HIV-antibody-positive (HIV+) men. The participants (mean age = 32 years) were interviewed about the life stress that they had experienced in the previous 6 相似文献
3.
A. Zielke C. Hasse Th. Bandorski H. Sitter P. Wachsmuth R. Grobholz M. Rothmund 《Surgical endoscopy》1997,11(12):1194-1197
Background: Recent studies have documented the feasibility of ultrasonography (US) to diagnose acute colonic diverticulitis (ACD). This
prospective observational trial determined the sonomorphology of ACD and evaluated the diagnostic accuracy of routine US performed
on admission by surgeons in training.
Methods: Fifty-seven consecutive patients with a confirmed episode of ACD were entered into this study, and the sonomorphology of
the involved colon was assessed. US findings were compared to the results of the clinical evaluation and correlated to the
clinicopathological outcome.
Results: The sonomorphology of ACD was characterized by segmental inflammatory transformation of the colon averaging 9.9 ± 3.2 cm
(range, 6–20) in length and visualized as target phenomena of a mean 3.5 ± 0.8 cm (range, 2.4–4.8) width. Targets were caused
by hypoechogenic thickening of the colonic wall of an average 7.7 ± 2.6 mm (range, 4–18). In 40% of cases, a hyperechogenic
halo representing peridiverticulitis (average width, 2.3 ± 0.6; range, 1.2–3 cm) was noted. Diverticula were seen in almost
half of the cases. Of the 57 cases with confirmed ACD, the diagnosis was made by US in 48, for a global accuracy of 84.2%.
US was false negative in nine patients, suggesting perforated appendicitis in five cases and acute appendicitis in one (the
final diagnoses were perforated sigmoid diverticulitis in five cases and cecal diverticulitis in one case). In three patients,
US was nondiagnostic.
Conclusion: In the hands of sonographically trained surgeons, ultrasound is a useful modality to image acute colonic diverticulitis.
US reveals diagnostic sonomorphology in most cases of ACD and therefore facilitates early confirmation of the diagnosis and
assessment of severity.
Received: 3 October 1996/Accepted: 9 May 1997 相似文献
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Lucia Carvalho Monica Lipay Francisco Belfort Ivan Santos Joyce Andrade Alessandra Haddad Flavia Brunstein Lydia Ferreira 《Journal of plastic, reconstructive & aesthetic surgery》2006,59(9):961-968
BACKGROUND: Telomerase activity (TA) is believed to play a role in the regulation of senescence and to limit the number of cell divisions. The deregulation of telomerase appears to contribute to oncogenesis and the formation of immortal cell lines. As a result, it is believed that it could be used as a prognostic marker in melanoma. METHODS: TA was assayed by the polymerase chain reaction PCR-ELISA-based telomeric repeat amplification protocol (TRAP assay). One hundred and eight samples were distributed in four histological groups: 30 samples from primary cutaneous melanomas, 24 from peritumoural skin sites, 28 from benign melanocytic lesions, and 26 from normal skin sites as a control. RESULTS: TA was different among the four tested groups (Kruskall-Wallis test p<0.001), and increasing values of TA were observed progressing from normal skin to benign and then to malignant lesions. Among melanoma samples, there was a significant association between TA and ulceration (p=0.025), TA and vascular invasion (p=0.018) and TA and mitotic rate (p=0.029) (Mann-Whitney test). A linear regression analysis showed significant associations between the increase of TA with Breslow thickness (p=0.004) and the presence of satellites (p=0.002). CONCLUSIONS: We observed that TA had increased from control skin to peritumoural skin, and then to benign melanocytic lesions and finally to melanoma, suggesting tumour progression. TA showed higher values in the presence of some important histopathologic parameters related to poor prognosis in cutaneous melanoma such as ulceration, vascular invasion, satellites, high rates of mitosis, and in thicker tumours. 相似文献
7.
W. Wachsmuth 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1948,260(5-6):411-425
Ohne ZusammenfassungMit 11 TextabbildungenHerrn Prof. Dr.E. v. Redwitz zum 65. Geburtstag. 相似文献
8.
Dr. med. Hans Wachsmuth 《European archives of psychiatry and clinical neuroscience》1913,52(3):993-1014
Ohne Zusammenfassung 相似文献
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Sunny E Ohia S Olubusayo Awe Catherine A Opere Angela M LeDay Lydia C Harris Kaustubh Kulkarni Najam A Sharif 《Journal of ocular pharmacology and therapeutics》2003,19(6):599-609
The glucose deprivation-induced release of [3H]D-aspartate was studied in bovine and human retinas in a superfusion apparatus. [3H]D-aspartate release was significantly increased upon omitting glucose in the superfusion buffer. This effect was dependent on external Ca2+ because L- and N-type Ca2+-channel blockers, such as diltiazem (1 microM), nitrendipine (1 microM), and omega-conotoxin (100 nM), significantly reduced the effect of glucose-deprivation induced release of [3H]D-aspartate. Furthermore, while glutamate receptor agonists (L-glutamate, N-methyl-D-aspartate, but not kainate) potentiated the effects of glucose deprivation, antagonists (MK-801, MCPG, ifenprodil, and L-AP3) at these receptors blocked the glucose deprivation-induced release process. Taken together, these studies have demonstrated that under conditions of glucose deprivation, as may happen during ischemic events in vivo, the retinal glutamatergic nerve endings and/or glial cells promote the efflux of [3H]D-aspartate into the extracellular environment. This process appears to be receptor-mediated and dependent on extracellular Ca2+ and is similar to previous reports pertaining to brain tissues. 相似文献