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Leyli Ghaeni Eberhard Siebert Florian Ostendorf Matthias Endres Uwe Reuter 《Journal of neurology》2010,257(4):678-680
Neurological manifestation of Churg-Strauss syndrome (CSS) is common and usually consists of peripheral neuropathy due to
small-vessel vasculitis, while cerebral manifestation is less frequent. We report the case of a 77-year-old woman with multiple
cerebral infarctions and hypereosinophilia. The presence of hypereosinophilia, asthma, sinusitis and vasculitis led to the
diagnosis of CSS. As cerebral infarctions occurred monophasically and an elevation of heart enzymes was present, we assumed
cardiac involvement and multiple cerebral infarctions due to cardiac embolism. Treatment with high-dose IV methylprednisone
and cyclophosphamide pulses led to significant improvement. This case illustrates multiple cerebral infarctions in CSS. CSS
should always be considered in patients with hypereosinophilia and stroke. 相似文献
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Harald Prüss Konstantin Prass Leyli Ghaeni Milan Milosevic Claudia Muselmann Dorette Freyer Georg Royl Uwe Reuter Nevena Baeva Ulrich Dirnagl Andreas Meisel Josef Priller 《Journal of cerebral blood flow and metabolism》2008,28(3):526-539
Nitric oxide produced by the inducible nitric oxide synthase (iNOS) is believed to participate in the pathogenic events after cerebral ischemia. In this study, we examined the expression of iNOS in the brain after transient focal cerebral ischemia in mice. We detected differential expression of exons 2 and 3 of iNOS mRNA (16-fold upregulation at 24 to 72 h after middle cerebral artery occlusion, MCAO) compared with exons 6 to 8, 12 to 14, 21 to 22, and 26 to 27 (2- to 5-fold upregulation after 72 and 96 h), which would be compatible with alternative splicing. Expression levels of iNOS mRNA were too low for detection by the Northern blot analysis. Using specific antibodies, we did not detect any iNOS immunoreactivity in the mouse brain 1 to 5 days after MCAO, although we detected iNOS immunoreactivity in the lungs of mice with stroke-associated pneumonia, and in mouse and rat dura mater after lipopolysaccharide administration. In chimeric iNOS-deficient mice transplanted with wild-type bone marrow (BM) cells expressing the green fluorescent protein (GFP) or in wild-type mice transplanted with GFP(+) iNOS-deficient BM cells, no expression of iNOS was detected in GFP(+) leukocytes invading the ischemic brain or in resident brain cells. Moreover, both experimental groups did not show any differences in infarct size. Analysis of three different strains of iNOS-deficient mice and wild-type controls confirmed that infarct size was independent of iNOS deletion, but strongly confounded by the genetic background of mouse strains. In conclusion, our data suggest that iNOS is not a universal mediator of brain damage after cerebral ischemia. 相似文献
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Meltem Gursu Sami Uzun Derya Topcuoğlu Leyli Kadriye Koc Lamiye Yucel Abdullah Sumnu Egemen Cebeci Oktay Ozkan Ahmet Behlul Leyla Koc Savas Ozturk Rumeyza Kazancioglu 《World Journal of Nephrology》2016,5(4):372-377
AIM: To examine all skin changes in peritoneal dialysis (PD) patients followed up in our unit.
METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded. The demographic, clinical and laboratory data including measures of dialysis adequacy of patients were recorded also. Statistical Package for Social Sciences (SPSS) for Windows 16.0 standard version was used for statistical analysis.
RESULTS: Among the patients followed up in our PD unit, those without exclusion criteria who gave informed consent, 38 patients were included in the study with male/female ratio and mean age of 26/12 and 50.3 ± 13.7 years, respectively. The duration of CKD was 7.86 ± 4.16 years and the mean PD duration was 47.1 ± 29.6 mo. Primary kidney disease was diabetic nephropathy in 11, nephrosclerosis in six, uropathologies in four, chronic glomerulonephritis in three, chronic pyelonephritis in three, autosomal dominant polycystic kidney disease in three patients while cause was unknown in eight patients. All patients except for one patient had at least one skin lesion. Loss of lunula, onychomycosis and tinea pedis are the most frequent skin disorders recorded in the study group. Diabetic patients had tinea pedis more frequently (P = 0.045). No relationship of skin findings was detected with primary renal diseases, comorbidities and medications that the patients were using.
CONCLUSION: Skin abnormalities are common in in PD patients. The most frequent skin pathologies are onychomycosis and tinea pedis which must not be overlooked. 相似文献
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Abedin Saghafipour Amir Hamta Keyvan Ezimand Leyli Zanjirani Farahani Mohammad Javanbakht Nazanin Soltani 《Asian Pacific Journal of Tropical Biomedicine》2021,(1):40-46
Objective: To determine the effect of climatic and environmental factors on the incidence of cutaneous leishmaniasis in Qom province in 2018. Methods: In this c... 相似文献
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Hosseinzadeh H Sadeghnia HR Ghaeni FA Motamedshariaty VS Mohajeri SA 《Phytotherapy research : PTR》2012,26(3):381-386
Cerebral ischemia produces brain damage and related behavioral deficits such as memory. In this study, a rat model of chronic cerebral hypoperfusion was used to determine whether saffron extract and crocin, which are potent antioxidants and free radical scavengers, can reduce vascular cognitive impairment. Male adult Wistar rats were administered different doses of an aqueous solution of crocin or hydroalcohol extract of saffron intraperitoneally (i.p.) 5 days after permanent occlusion of the common carotid arteries. Spatial learning and memory were assessed in training trials, 7–11 days after common carotid artery ligation using the Morris water maze. The results showed that the escape latency time was significantly reduced from 24.64 s in the control group to 8.77 and 10.47 s by crocin (25 mg/kg) and saffron extract (250 mg/kg). The traveled distance to find the platform was also changed from 772 cm in the control group to 251 and 294 cm in the crocin (25 mg/kg) and saffron extract (250 mg/kg) groups. The percentages of time spent in the target quadrant, in comparison with the control group (24.16%), increased to 34.25% in the crocin (25 mg/kg) and 34.85% in the saffron extract (250 mg/kg) group. This study suggests that saffron extract and crocin improve spatial cognitive abilities following chronic cerebral hypoperfusion and that these effects may be related to the antioxidant effects of these compounds. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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Adrin Palencia‐Campos María‐Luisa Martínez‐Fernndez Umut Altunoglu Patricia Soto‐Bielicka Antonio Torres Purificacin Marín Elena Aller Leyli entürk
mer Berkz Mehmet Yldran Hülya Kayserili Elena Gil‐Camarero Gloria Colli‐Lista Amparo Sanchís‐Calvo Alba Carretero Encarna Guilln‐Navarro Vanesa Lpez‐Gonzlez María Ballesta‐Martínez Jordi Rosell Mona S. Aglan Samia Temtamy Ghada A. Otaify Lourdes Cuevas‐Catalina María‐Nieves Torres‐Saavedra Julian Nevado Jair Tenorio Pablo Lapunzina Eva Bermejo‐Snchez Víctor L. Ruiz‐Prez 《Human mutation》2020,41(1):265-276
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