全文获取类型
| 收费全文 | 15374篇 |
| 免费 | 1413篇 |
| 国内免费 | 66篇 |
专业分类
| 耳鼻咽喉 | 216篇 |
| 儿科学 | 691篇 |
| 妇产科学 | 141篇 |
| 基础医学 | 1949篇 |
| 口腔科学 | 394篇 |
| 临床医学 | 1557篇 |
| 内科学 | 3137篇 |
| 皮肤病学 | 349篇 |
| 神经病学 | 1484篇 |
| 特种医学 | 950篇 |
| 外国民族医学 | 1篇 |
| 外科学 | 1978篇 |
| 综合类 | 243篇 |
| 一般理论 | 21篇 |
| 预防医学 | 1272篇 |
| 眼科学 | 325篇 |
| 药学 | 1118篇 |
| 中国医学 | 12篇 |
| 肿瘤学 | 1015篇 |
出版年
| 2021年 | 229篇 |
| 2020年 | 207篇 |
| 2019年 | 223篇 |
| 2018年 | 295篇 |
| 2017年 | 240篇 |
| 2016年 | 230篇 |
| 2015年 | 274篇 |
| 2014年 | 374篇 |
| 2013年 | 620篇 |
| 2012年 | 772篇 |
| 2011年 | 806篇 |
| 2010年 | 505篇 |
| 2009年 | 498篇 |
| 2008年 | 700篇 |
| 2007年 | 746篇 |
| 2006年 | 750篇 |
| 2005年 | 770篇 |
| 2004年 | 713篇 |
| 2003年 | 703篇 |
| 2002年 | 700篇 |
| 2001年 | 283篇 |
| 2000年 | 254篇 |
| 1999年 | 271篇 |
| 1998年 | 278篇 |
| 1997年 | 272篇 |
| 1996年 | 249篇 |
| 1995年 | 232篇 |
| 1994年 | 161篇 |
| 1993年 | 187篇 |
| 1992年 | 202篇 |
| 1991年 | 176篇 |
| 1990年 | 184篇 |
| 1989年 | 223篇 |
| 1988年 | 178篇 |
| 1987年 | 151篇 |
| 1986年 | 167篇 |
| 1985年 | 164篇 |
| 1984年 | 151篇 |
| 1983年 | 165篇 |
| 1982年 | 180篇 |
| 1981年 | 153篇 |
| 1980年 | 160篇 |
| 1979年 | 118篇 |
| 1978年 | 128篇 |
| 1977年 | 109篇 |
| 1976年 | 109篇 |
| 1974年 | 105篇 |
| 1973年 | 108篇 |
| 1972年 | 96篇 |
| 1971年 | 100篇 |
排序方式： 共有10000条查询结果，搜索用时 343 毫秒
1.
2.
3.
4.
5.
Accuracy and Precision of Acetabular Component Placement With Imageless Navigation in Obese Patients
Leonard T. Buller Alexander S. McLawhorn Jose A. Romero Peter K. Sculco David J. Mayman 《The Journal of arthroplasty》2019,34(4):693-699
Background
Obesity is a risk factor for acetabular component malposition when total hip arthroplasty is performed with manual techniques. The utility of imageless navigation in obese patients remains unknown. This study compared the accuracy and precision of imageless navigation for component orientation between obese and nonobese patients.Methods
A total of 459 total hip arthroplasties performed for osteoarthritis using imageless navigation were reviewed from a single surgeon’s institutional review board–approved database. Einzel-Bild-Roentgen Analyse determined component orientation on 6-week postoperative anteroposterior radiographs. Mean orientation error (accuracy) and precision were compared between obese (body mass index ≥ 30 kg/m2) and nonobese patients. Regression analysis evaluated the influence of obesity on component position.Results
The difference in mean inclination and anteversion between obese and nonobese groups was 1.1° (43.0° ± 3.5°; range, 35.8°-57.8° vs 41.9° ± 4.4°; range, 33.0°-57.1° and 24.9° ± 6.3°; range, 14.2°-44.3° vs 23.8° ± 6.6°; range, 7.0°-38.6°, respectively). Inclination precision was better for nonobese patients. No difference in inclination accuracy or anteversion accuracy or precision was detected between groups. And 83% of components were placed within the target range. There was no relationship between obesity (dichotomized) and component placement outside the target ranges for inclination, anteversion, or both. As a continuous variable, increased body mass index correlated with higher odds of inclination outside the target zone (odds ratio, 1.06; P = .001).Conclusion
Using imageless navigation, inclination orientation was less precise for obese patients, but the observed difference is likely not clinically relevant. Accurate superficial registration of landmarks in obese patients is achievable, and the use of imageless navigation similarly improves acetabular component positioning in obese and nonobese patients.Level of Evidence
Therapeutic Level IV. 相似文献6.
7.
Sebastian Mondaca Walid K. Chatila David Bates Jaclyn F. Hechtman Andrea Cercek Neil H. Segal Zsofia K. Stadler Anna M. Varghese Ritika Kundra Marinela Capanu Jinru Shia Nikolaus Schultz Leonard Saltz Rona Yaeger 《Clinical colorectal cancer》2019,18(1):e39-e52
Background
Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. We examined the safety and efficacy of a modified schedule, FOLFCIS (leucovorin, fluorouracil, and cisplatin), and performed an integrated clinical and genomic analysis of anal SCC.Patients and Methods
We reviewed all patients with advanced anal SCC receiving first-line FOLFCIS chemotherapy – essentially a FOLFOX (leucovorin, fluorouracil, and oxaliplatin) schedule with cisplatin substituted for oxaliplatin – in our institution between 2007 and 2017, and performed deep sequencing to identify genomic markers of response and key genomic drivers.Results
Fifty-three patients with advanced anal SCC (48 metastatic; 5 unresectable, locally advanced) received first-line FOLFCIS during this period; all were platinum-naive. The response rate was 48% (95% confidence interval [CI], 32.6%-63%). With a median follow-up of 41.6 months, progression-free survival and overall survival were 7.1 months (95% CI, 4.4-8.6 months) and 22.1 months (95% CI, 16.9-28.1 months), respectively. Among all patients with advanced anal SCC that underwent sequencing during the study period, the most frequent genomic alterations consisted of chromosome 3q amplification (51%) and mutations in PIK3CA (29%) and KMT2D (22%). No genomic alteration correlated with response to platinum-containing treatment. Although there were few cases, patients with human papillomavirus-negative anal SCC did not appear to benefit from FOLFCIS, and all harbored distinct genomic profiles with TP53, TERT promoter, and CDKN2A mutations.Conclusions
FOLFCIS appears effective and safe as first-line chemotherapy in patients with advanced anal SCC and represents an alternative treatment option for these patients. 相似文献8.
9.
10.
The authors present a case of rickets in an adolescent girl who presented to the emergency department with bone pain. Emergency department staff should be aware that rickets is not just a disease of early childhood. 相似文献