全文获取类型
收费全文 | 18749篇 |
免费 | 1124篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 75篇 |
儿科学 | 415篇 |
妇产科学 | 218篇 |
基础医学 | 2344篇 |
口腔科学 | 735篇 |
临床医学 | 1884篇 |
内科学 | 4239篇 |
皮肤病学 | 384篇 |
神经病学 | 1989篇 |
特种医学 | 893篇 |
外科学 | 3013篇 |
综合类 | 108篇 |
一般理论 | 4篇 |
预防医学 | 1203篇 |
眼科学 | 130篇 |
药学 | 1242篇 |
中国医学 | 24篇 |
肿瘤学 | 1053篇 |
出版年
2023年 | 145篇 |
2022年 | 154篇 |
2021年 | 386篇 |
2020年 | 289篇 |
2019年 | 403篇 |
2018年 | 480篇 |
2017年 | 453篇 |
2016年 | 428篇 |
2015年 | 496篇 |
2014年 | 667篇 |
2013年 | 1053篇 |
2012年 | 1372篇 |
2011年 | 1304篇 |
2010年 | 814篇 |
2009年 | 783篇 |
2008年 | 1195篇 |
2007年 | 1253篇 |
2006年 | 1204篇 |
2005年 | 1156篇 |
2004年 | 995篇 |
2003年 | 996篇 |
2002年 | 930篇 |
2001年 | 166篇 |
2000年 | 111篇 |
1999年 | 136篇 |
1998年 | 193篇 |
1997年 | 203篇 |
1996年 | 145篇 |
1995年 | 142篇 |
1994年 | 143篇 |
1993年 | 138篇 |
1992年 | 109篇 |
1991年 | 109篇 |
1990年 | 95篇 |
1989年 | 95篇 |
1988年 | 86篇 |
1987年 | 83篇 |
1986年 | 76篇 |
1985年 | 83篇 |
1984年 | 72篇 |
1983年 | 79篇 |
1982年 | 77篇 |
1981年 | 75篇 |
1980年 | 58篇 |
1979年 | 52篇 |
1978年 | 62篇 |
1977年 | 52篇 |
1976年 | 43篇 |
1975年 | 46篇 |
1973年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Mina Jane Zafar Thomas Kallemose Mostafa Benyahia Lars Bo Ebskov Jeannette
stergaard Penny 《Acta orthopaedica》2020,91(4):444
Background and purpose — Total ankle arthroplasties (TAAs) have larger revision rates than hip and knee implants. We examined the survival rates of our primary TAAs, and what different factors, including the cause of arthritis, affect the success and/or revision rate.Patients and methods — From 2004 to 2016, 322 primary Hintegra TAAs were implanted: the 2nd generation implant from 2004 until mid-2007 and the 3rd generation from late 2007 to 2016. A Cox proportional hazards model evaluated sex, age, primary diagnosis, and implant generation, pre- and postoperative angles and implant position as risk factors for revision.Results — 60 implants (19%) were revised, the majority (n = 34) due to loosening. The 5-year survival rate (95% CI) was 75% (69–82) and the 10-year survival rate was 68% (60–77). There was a reduced risk of revision, per degree of increased postoperative medial distal tibial angle at 0.84 (0.72–0.98) and preoperative talus angle at 0.95 (0.90–1.00), indicating that varus ankles may have a larger revision rate. Generation of implant, sex, primary diagnosis, and most pre- and postoperative radiological angles did not statistically affect revision risk.Interpretation — Our revision rates are slightly above registry rates and well above those of the developer. Most were revised due to loosening; no difference was demonstrated with the 2 generations of implant used. Learning curve and a low threshold for revision could explain the high revision rate.Arthritis in the ankle often develops earlier than in the hip or knee, and 70% have a traumatic etiology (Saltzman et al. 2005, Brown et al. 2006). Total ankle arthroplasty (TAA) can be indicated for severe arthritis in the ankle joint, but the anatomical preconditions, like a small surface area and high stress from compression and torque (Bouguecha et al. 2011, Kakkar and Siddique 2011), makes it less durable than hip and knee prosthetics. The Hintegra TAA, a 3-component mobile bearing, uncemented implant (Hintermann et al. 2004) is widely used and results from the development center demonstrate survival rates of 94% and 84% after 5 and 10 years’ follow-up (Barg et al. 2013). This is considerably more than the survival rates from national registries. Labek et al. (2011) demonstrated that development centers report only half of the revision rate that can be found in the few existing national registers. In a systematic review of primary Agility total ankle arthroplasty (DePuy Synthes Orthopedics, Warsaw, IN, USA), the author (Roukis 2012) found that the incidence of complications increased from 7% to 12%, in studies where the inventor was excluded. Similar results were found by Prissel and Roukis (2013), who found an increased incidence of complications from 6% to 13% in studies where the inventor or faculty consultants were excluded. These studies indicated the risk of selection (inventor) and publication (conflict of interest) bias.Planning and surgical technique, including significant experience, are mandatory for a successful outcome. The better result from development centers may reflect, besides the above-mentioned bias, that there is a long learning curve and that the indication for revision surgery varies.We examined the survival rates of primary Hintegra TAAs performed at Hvidovre Hospital, with revision rate as outcome. We report primary diagnosis for primary TAA and examine whether sex, generation of the implant, preoperative angles and implant position affect the revision rate. 相似文献
3.
4.
5.
Oliveira Gonalves Ana Sofia Panteli Dimitra Neeb Lars Kurth Tobias Aigner Annette 《The European journal of health economics》2022,23(1):47-57
The European Journal of Health Economics - The aims of this study were to assess whether there is a conceptual overlap between the questionnaires HIT-6 and EQ-5D and to develop a mapping algorithm... 相似文献
6.
7.
8.
9.
Lars J Vatten Tom I L Nilsen P?l R Romundstad Wenche B Dr?yvold Jostein Holmen 《European journal of cardiovascular prevention and rehabilitation》2006,13(6):909-915
OBJECTIVE: To investigate whether cardiovascular mortality related to obesity could be modified by physical activity. DESIGN: Mortality follow-up. SETTING: Population study. PARTICIPANTS: Participants in a health survey: 34 868 women and 32 872 men free from known cardiovascular disease or diabetes at baseline. MAIN OUTCOME MEASURES: Total cardiovascular mortality. MAIN RESULTS: During 16 years of follow-up, 3026 women and 3526 men had died from cardiovascular causes. In middle age, obesity [body mass index (BMI) of 30 or higher] was associated with increased risk of cardiovascular death, but the association weakened with age. After 70, there was no association between BMI and cardiovascular death. At all ages, a lower level of physical activity was associated with a higher cardiovascular mortality. In women with high physical activity, indicated by at least 30 min of moderate to vigorous activity more than once a week, cardiovascular mortality was only slightly higher in the obese compared to lean women (adjusted relative risk, 1.27; 95% confidence interval, 0.80-2.00). In men with high physical activity, cardiovascular mortality was, however, significantly higher among the obese (relative risk, 1.62; 95% confidence interval, 1.09-2.40). In both genders cardiovascular mortality was substantially higher in obese people who reported no regular physical activity compared to obese people with a high level of physical activity. CONCLUSION: In obese women, being highly active may, to a large extent, compensate for the risk-increasing effect of being obese, whereas in obese men who engage in a high level of physical activity, the risk of cardiovascular death may be higher than in lean and equally active men. 相似文献
10.
Sergue? O Fetissov Jarmila Hallman Ida Nilsson Ann-Kari Lefvert Lars Oreland Tomas H?kfelt 《Neuropsychopharmacology》2006,60(8):799-802
BACKGROUND: Altered stress response is characteristic for subjects with abnormal aggressive and antisocial behavior, but the underlying biological mechanisms are unclear. We hypothesized that autoantibodies (autoAbs) directed against several stress-related neurohormones may exist in aggressive subjects. METHODS: Using enzyme-linked immunosorbent assay, we studied whether autoAbs directed against corticotropin (ACTH), alpha-melanocyte-stimulating hormone (alpha-MSH), oxytocin, and vasopressin are present in serum of male subjects with conduct disorder and prisoners with history of violence. Healthy blood donors served as control subjects. RESULTS: Both conduct disorder and prisoners groups displayed strongly increased levels of ACTH-reactive immunoglobulin G (IgG) and immunoglobulin M (IgM) autoAbs compared with control subjects. Levels of oxytocin-reactive IgM autoAbs were slightly increased in both groups of aggressive subjects, whereas levels of vasopressin-reactive IgG and IgM autoAbs were lower only in conduct disorder. No differences in the levels of alpha-MSH-reactive autoAbs were found between aggressive and control subjects. CONCLUSIONS: High levels of ACTH-reactive autoAbs as well as altered levels of oxytocin- and vasopressin-reactive autoAbs found in aggressive subjects may interfere with the neuroendocrine mechanisms of stress and motivated behavior. Our data suggest a new biological mechanism of human aggressive behavior that involves autoAbs directed against several stress-related neurohormones. 相似文献