全文获取类型
收费全文 | 44639篇 |
免费 | 2566篇 |
国内免费 | 281篇 |
专业分类
耳鼻咽喉 | 434篇 |
儿科学 | 654篇 |
妇产科学 | 598篇 |
基础医学 | 5797篇 |
口腔科学 | 1218篇 |
临床医学 | 2848篇 |
内科学 | 10990篇 |
皮肤病学 | 1103篇 |
神经病学 | 2986篇 |
特种医学 | 1726篇 |
外科学 | 8242篇 |
综合类 | 217篇 |
一般理论 | 1篇 |
预防医学 | 1381篇 |
眼科学 | 781篇 |
药学 | 3121篇 |
中国医学 | 74篇 |
肿瘤学 | 5315篇 |
出版年
2023年 | 229篇 |
2022年 | 398篇 |
2021年 | 943篇 |
2020年 | 549篇 |
2019年 | 691篇 |
2018年 | 881篇 |
2017年 | 771篇 |
2016年 | 864篇 |
2015年 | 942篇 |
2014年 | 1224篇 |
2013年 | 1468篇 |
2012年 | 2240篇 |
2011年 | 2451篇 |
2010年 | 1384篇 |
2009年 | 1247篇 |
2008年 | 2111篇 |
2007年 | 2181篇 |
2006年 | 2234篇 |
2005年 | 2300篇 |
2004年 | 2156篇 |
2003年 | 2132篇 |
2002年 | 1981篇 |
2001年 | 1418篇 |
2000年 | 1467篇 |
1999年 | 1353篇 |
1998年 | 559篇 |
1997年 | 479篇 |
1996年 | 430篇 |
1995年 | 371篇 |
1994年 | 312篇 |
1993年 | 319篇 |
1992年 | 872篇 |
1991年 | 766篇 |
1990年 | 782篇 |
1989年 | 741篇 |
1988年 | 751篇 |
1987年 | 642篇 |
1986年 | 634篇 |
1985年 | 618篇 |
1984年 | 417篇 |
1983年 | 338篇 |
1982年 | 167篇 |
1981年 | 150篇 |
1979年 | 324篇 |
1978年 | 221篇 |
1977年 | 164篇 |
1975年 | 157篇 |
1974年 | 218篇 |
1973年 | 155篇 |
1972年 | 171篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Keiko Goto Yutaka Fujiwara Takeshi Isobe Naoko Chayahara Naomi Kiyota Toru Mukohara Yukari Tsubata Takamasa Hotta Kenji Tamura Noboru Yamamoto Hironobu Minami 《Cancer science》2019,110(6):1987-1994
Although dose reduction of S‐1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of the present study was to investigate the pharmacokinetic parameters of 5‐fluorouracil, 5‐chloro‐2,4 dihydroxypyridine and oteracil potassium, and to review the recommended dose modification of S‐1 in patients with renal impairment. We classified patients receiving S‐1 into 4 groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. The daily S‐1 dose was adjusted based on the patient's eGFR and body surface area. Blood samples were collected for pharmacokinetic analysis. A total of 33 patients were enrolled and classified into 4 groups as follows: 10 patients in cohort 1 (eGFR ≥ 80 mL/min/1.73 m2), 10 patients in cohort 2 (eGFR = 50‐79 mL/min/1.73 m2), 10 patients in cohort 3 (eGFR = 30‐49 mL/min/1.73 m2), and 3 patients in cohort 4 (eGFR < 30 mL/min/1.73 m2). Those in cohorts 3 and 4 treated with an adjusted dose of S‐1 showed a similar area under the curve for 5‐fluorouracil (941.9 ± 275.6 and 1043.5 ± 224.8 ng/mL, respectively) compared with cohort 2 (1034.9 ± 414.3 ng/mL). Notably, while there was a statistically significant difference between cohort 1 (689.6 ± 208.8 ng/mL) and 2 (P = 0.0474) treated with an equal dose of S‐1, there was no significant difference observed in the toxicity profiles of the cohorts. In conclusion, dose adjustment of S‐1 in patients with impaired renal function using eGFR is appropriate and safe. 相似文献
2.
3.
4.
5.
6.
7.
Masaru Sasaki Tsuyoshi Takahashi Soichiro Funaki Koji Tanaka Yasuhiro Miyazaki Naoko Ose Tomoki Makino Yukinori Kurokawa Makoto Yamasaki Kiyokazu Nakajima Yasushi Shintani Masaki Mori Yuichiro Doki 《Asian journal of endoscopic surgery》2021,14(1):116-119
We report a case of a diaphragmatic hernia after a heart transplant operation. A 43-year-old woman, who underwent orthotropic heart transplantation for hypertrophic cadiomyopathy two year earlier, presented with vomiting and epigastric pain. A computed tomography scan showed that the stomach and transverse colon were dislocated in the left thoracic cavity. We diagnosed left diaphragmatic hernia incarceration and performed laparoscopic repair of the diaphragmatic hernia. A 12 × 8 cm diaphragmatic defect was found intraoperatively on the ventrolateral aspect of the left diaphragm, and the stomach with volvulus had herniated into the thorax through the defect. The hernia was considered to be iatrogenic. The diaphragmatic defect was large, and the diaphragm was thinning. We closed the defect by mesh repair. Laparoscopic mesh repair of the diaphragmatic hernia could be performed safely and with minimal invasiveness. 相似文献
8.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献9.
10.