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1.
A M Dyga? N A Klimenko E V Abramova V P Khakhov I V Bogdashin O Iu Zakharova E V Simanina E Iu Sherstoboev B Iu Gumilevski? D A Boldyshev 《Patologicheskaia fiziologiia i èksperimental'naia terapiia》1991,(6):28-31
A model of acute infectious peritonitis in mice demonstrated that the inflammation is attended by marked biphasic activation of bone-marrow granulomonocytopoiesis and that the activation is due in many respects to increased functional activity of elements forming the hemopoiesis-inducing microenvironment. This was suggested by increased colony-stimulating activity of the marrow mononuclear cells and the content of hemopoietic islets in the marrow. The colony-stimulating activity of peripheral blood also increased. It was established that inflammation is also characterized by activation of bone-marrow erythropoiesis, which is linked with increased erythropoietic activity of the hemopoiesis-inducing microenvironment and blood. There was a relation between the hemopoietic changes and the kinetics of leukocytes in the focus of inflammation. 相似文献
2.
3.
Oscillatory motion of the normal cervical spinal cord 总被引:2,自引:0,他引:2
4.
V. P. Chernyshov E. V. Vykhovanets I. I. Slukvin Yu. A. Antipkin A. N. Vasyuk E. F. Klimenko 《Bulletin of experimental biology and medicine》1998,126(2):835-838
Examination of thyroid function and immune status of children living on the territories polluted by radionuclides in 1993–1994
revealed131I-dependent thyroid autoimmune reactions. These data indicate a possible effect of131I on the pituitary-thyroid and immune systems of children living on the radiation controlled territories.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 216–220, August, 1998 相似文献
5.
6.
E. D. Klimenko O. M. Pozdnyakov 《Bulletin of experimental biology and medicine》1992,114(4):1557-1559
Laboratory of Experimental Pathomorphology, Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow. (Presented by Academician of the Russian Academy of Medical Sciences D. S. Sarkisov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 114, No. 10, pp. 437–439, October, 1992. 相似文献
7.
Degranulation of mast cells of a peritoneal suspension and of the mesentery of the small intestine and liberation of histamine and serotonin in albino rats with acute aseptic peritonitis were shown to begin during the first minute after injury and to reach a maximum at the fifth minute. By the 15th minute the concentrations of the free amines had fallen sharply and did not differ significantly from the initial levels. The dynamics of the immediate phase of increased vascular permeability corresponded to the dynamics of the free amines. The most marked increase in vascular permeability was observed at the 10th–15th minutes. By the 20th minute it was appreciably lower. Preliminary exhaustion of histamine and serotonin reserves reduced the degree of disturbance of vascular permeability only during the first 15 min after application of the inflammatory agent. It is conculted that histamine and serotonin cause disturbance of vascular permeability in acute aseptic peritonitis chiefly during the first 15 min after injury.Department of Pathological Physiology, Khar'kov Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. D. Ado.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 12, pp. 660–664, December, 1977. 相似文献
8.
Mutational analysis of the SOX9 gene in campomelic dysplasia and autosomal sex reversal: lack of genotype/phenotype correlations 总被引:9,自引:1,他引:9
Meyer J; Sudbeck P; Held M; Wagner T; Schmitz ML; Bricarelli FD; Eggermont E; Friedrich U; Haas OA; Kobelt A; Leroy JG; Van Maldergem L; Michel E; Mitulla B; Pfeiffer RA; Schinzel A; Schmidt H; Scherer G 《Human molecular genetics》1997,6(1):91-98
It has previously been shown that, in the heterozygous state, mutations in
the SOX9 gene cause campomelic dysplasia (CD) and the often associated
autosomal XY sex reversal. In 12 CD patients, 10 novel mutations and one
recurrent mutation were characterized in one SOX9 allele each, and in one
case, no mutation was found. Four missense mutations are all located within
the high mobility group (HMG) domain. They either reduce or abolish the
DNA-binding ability of the mutant SOX9 proteins. Among the five nonsense
and three frameshift mutations identified, two leave the C-terminal
transactivation (TA) domain encompassing residues 402-509 of SOX9 partly or
almost completely intact. When tested in cell transfection experiments, the
recurrent nonsense mutation Y440X, found in two patients who survived for
four and more than 9 years, respectively, exhibits some residual
transactivation ability. In contrast, a frameshift mutation extending the
protein by 70 residues at codon 507, found in a patient who died shortly
after birth, showed no transactivation. This is apparently due to
instability of the mutant SOX9 protein as demonstrated by Western blotting.
Amino acid substitutions and nonsense mutations are found in patients with
and without XY sex reversal, indicating that sex reversal in CD is subject
to variable penetrance. Finally, none of 18 female patients with XY gonadal
dysgenesis (Swyer syndrome) showed an altered SOX9 banding pattern in SSCP
assays, providing evidence that SOX9 mutations do not usually result in XY
sex reversal without skeletal malformations.
相似文献
9.
Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse 总被引:1,自引:3,他引:1
10.