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1.
Takashi Ito Ryuji Sakakibara MD Tatsuya Yamamoto Tomoyuki Uchiyama Zhi Liu Masato Asahina Morihiro Higashi Kimihito Arai Shoichi Ito Yusuke Awa Kaori Yamamoto Mika Kinou Tomonori Yamanishi Takamichi Hattori 《Clinical autonomic research》2006,16(1):66-71
Abstract Uro-neurological assessment was performed in four patients with small-fiber neuropathy due to amyloidosis (2 transthyretin-type/2
immunoglobulin light-chain-type). Voiding difficulties were due to detrusor weakness and impaired bladder sensation. In two
patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity. The
underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves. 相似文献
2.
Hideyuki Arima Yu Yamato Kimihito Sato Yoshihiro Uchida Toshiyuki Tsuruta Kanehisa Hashiguchi Hajime Hamamoto Eiichiro Watanabe Kaoru Yamanaka Tomohiko Hasegawa Go Yoshida Tatsuya Yasuda Tomohiro Banno Shin Oe Hiroki Ushirozako Tomohiro Yamada Koichiro Ide Yuh Watanabe Yukihiro Matsuyama 《Journal of orthopaedic science》2021,26(4):577-583
BackgroundSagittal spino-pelvic malalignment in patients with chronic low back pain (CLBP) have been reported in the past, which may also affect cervical spine lesions. The purpose of this study is to investigate the cervical alignment in patients with CLBP.MethodOf the patients who visited an orthopedic specialist due to low back pain lasting more than three months, 121 cases (average 71.5-years-old, 46 male and 75 female) with whole standing spinal screening radiographs were reviewed (CLBP group). Cervical parameters included cervical lordosis (CL), C2–C7 sagittal vertical axis (C2-7 SVA), and the T1 slope minus CL (T1S-CL). Cervical spine deformity was defined as C2-7 SVA >4 cm, CL <0°, or T1S-CL ≧20°. We compared the cervical alignment of these patients with 121 age and gender matched volunteers (control group).ResultsThe prevalence of cervical spine deformity was significantly higher in the CLBP group than in the control group (20.7% vs. 10.7%, P = 0.034). The mean CL was smaller in the CLBP group than in the control group (16.1° vs. 21.4°, P = 0.002). The mean C2-7 SVA was 17.6 mm vs. 18.7 mm in the CLBP group and in the control group, respectively (P = 0.817). The mean T1S-CL was larger in the CLBP group than in the control group (9.1° vs. 3.5°, P < 0.001). Multivariate analysis showed that people with CLBP were more likely to have cervical deformities than people without CLBP (odds ratio 2.16, 95% confidence interval 1.006 to 4.637).ConclusionsThis study results suggest that people with CLBP present with worse cervical sagittal alignment and higher prevalence of cervical spine deformities than age and gender matched volunteers with no CLBP. This means CLBP impacts cervical spine lesions negatively.Level of evidenceⅣ 相似文献
3.
4.
Rostral midbrain atrophy in progressive supranuclear palsy (PSP) is detected by mid-sagittal plain magnetic resonance imaging (MRI). The shape of the atrophy looks like the bill of a hummingbird (hummingbird sign). We studied this sign to elucidate the nature of midbrain atrophy in PSP. Eight patients with PSP, 12 with Parkinson's disease (PD), and 10 normal controls were studied. Using mid-sagittal plain MRI, we measured the rostral and caudal midbrain tegmentum (MT), superior and inferior colliculus, pontine base, and tegmentum. We compared the length of the interpeduncular fossa, which is posterior to the mammillary body, to the diameter of the midbrain tegmentum. The multiple comparison method was used for the statistical analysis. The hummingbird sign was demonstrated in all of the PSP patients studied, and it was not observed in PD patients nor in normal controls. The hummingbird sign in the PSP patients was due to the atrophy of the midbrain tegmentum (rostral and caudal) and to a relative increase in the length of the interpeduncular fossa over that of the anteroposterior diameter of the midbrain tegmentum. The hummingbird sign, which represents the atrophy of the rostral midbrain tegmentum, strongly suggests the involvement of the rostral interstitial nucleus of the medial longitudinal fasciculus in patients with PSP. Demonstration of a hummingbird sign on MRI is thought to be useful for a diagnosis of PSP. 相似文献
5.
Sakakibara R Uchiyama T Arai K Yamanishi T Hattori T 《Journal of the neurological sciences》2004,218(1-2):67-72
OBJECTIVES: Machado-Joseph disease (MJD), or hereditary spinocerebellar ataxia type 3, is the most common dominantly inherited ataxia. However, lower urinary tract (LUT) dysfunction in MJD has not been fully delineated. We investigated LUT dysfunction in MJD by clinical-urodynamic observations. METHODS: In 24 genetically diagnosed MJD, we recruited all 11 patients with LUT symptoms (six men, five women; age, 18-61 [mean 48] years; disease duration, 2-24 [mean 9] years; voiding difficulty, 7, urinary incontinence, 4). Urodynamic studies consisted of uroflowmetry, measurement of post-void residuals and electromyography (EMG)-cystometry. Neurophysiology tests consisted of motor unit potential (MUP) analysis of the sphincter and extremity muscles, tibial nerve somatosensory evoked potentials (SEP) and nerve conduction studies (NCS) of the extremities. RESULTS: Urodynamic abnormalities were seen in all 11 patients studied. Maximum or average flow rate was decreased in five. Post-void residual was noted in three but residual urine volume > 100 ml was noted in only one patient. Maximum urethral closure pressure was low in one and high in one of five patients studied. EMG-cystometry during filling showed detrusor overactivity in five, impaired bladder sensation in four, low compliance detrusor in one, uninhibited sphincter relaxation in one and incompetent urethra in one. Voiding phase abnormalities included detrusor areflexia in three and detrusor-sphincter dyssynergia in two. Bethanechol supersensitivity of the bladder was noted in one of three patients studied. Bulbocavernosus reflex was absent in two of five patients studied. MUP analysis showed neurogenic changes in six of nine sphincter muscles and in all six extremity muscles studied. Five patients had prolonged or absent cortical response in SEP and four had sensory axonal neuropathy in NCS, which were relevant to the impaired bladder sensation. CONCLUSION: In the present study, a half of MJD patients had LUT symptoms and they showed various urodynamic abnormalities. Detrusor overactivity, impaired bladder sensation, and neurogenic sphincter EMG were common findings, and large post-void residuals were rare. These findings are relevant to central and peripheral nervous system pathology of MJD. 相似文献
6.
Ichinose H Ohye T Shinotoh H Arai K Yamazaki S Mizuta E Kuno S Nagatsu T 《Parkinsonism & related disorders》2003,9(Z1):S11-S14
We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS. 相似文献
7.
Miwa Yoshida Yukako Mouri Sohei Yamamoto Kyoko Yorozuya Kimihito Fujii Shogo Nakano Takashi Fukutomi Kazuo Hara Hitoshi Tsuda 《Breast cancer (Tokyo, Japan)》2010,17(2):146-150
A 64-year-old man noticed a right subareolar mass in May 2005. On physical examination, an oval-shaped, well-circumscribedthe
tumor (6.0 × 5.5 cm in size) was located just beneath the right nipple. The tumor was elastic, firm and freely movable. Neither
axillary nor supraclavicular lymph nodes were palpable. Mammography demonstrated a 5 × 5-cm, relatively distinct and dense
mass without microcalcifications or spiculations. There were no findings of concurrent gynecomastia. Ultrasonography revealed
a large multilocular cyst with a mural hypoechoic protruding lesion exhibiting wide-based morphology with an irregular margin.
On contrast-enhanced computed tomography, the inner lesion enhanced, but direct invasion of the tumor to the major pectoral
muscle was not found. An intracystic papillary lesion, possibly papillary carcinoma, was suspected. In December 2007, wide
excision of the tumor was performed. On histopathological examination, the tumor had a papillary pattern with a small cribriform
component in the cystic wall with microinvasion of the stroma. Marginal status was negative. The final diagnosis of the disease
was a microinvasive intracystic papillary carcinoma of low grade without axillary lymph node metastases. Immunohistochemically,
estrogen receptor and progesterone receptor were both positive, but negative for HER-2 protein. No LOH on 16q could be detected.
The prognosis of the disease was unclear; however, the malignant potential of this condition may be more clearly determined
by studying the LOH on chromosome 16q. 相似文献
8.
Kyoko Yorozuya Toru Takeuchi Miwa Yoshida Yukako Mouri Junko Kousaka Kimihito Fujii Shogo Nakano Takashi Fukutomi Kazuo Hara Shu Ichihara Yingsong Lin Shogo Kikuchi 《Journal of cancer research and clinical oncology》2010,136(6):939-944
Purpose
We sought to evaluate the use of the Onco type DX Breast Cancer Assay for identifying candidates for adjuvant therapy in patients with estrogen receptor (ER)-positive, node-negative primary Stage I or IIA breast cancer.Methods
A retrospective case–control study was conducted on 40 patients who underwent surgery between 2000 and 2008. Cases (n = 10) were patients who had metastases after surgery. Controls (n = 30) were patients who did not develop metastases and were individually matched to their case with respect to age. All patients were analyzed with regard to age, tumor size, histological grade, HER2 status, and the values of Recurrence Score (RS), ER score and PgR score generated by Onco type DX. We also divided the patients into low, intermediate or high-risk groups according to individual RS values.Results
RS, risk category and histological grade were associated with metastases in patients with ER-positive, node-negative Stage I or IIA breast cancer. However, ER status, tumor size and PgR status were not associated with metastases. Histological grade was associated with RS value and the distribution pattern of risk category (P < 0.001 for each).Conclusions
Both histological grade and risk-category classification were effective in identifying women at risk of developing distant metastases after initial therapy for ER-positive, node-negative Stage I or IIA breast cancer. These patients may benefit from the addition of adjuvant therapy at diagnosis. 相似文献9.
Yu Koyama Masato Asahina Koiti Honma Kimihito Arai Takamichi Hattori 《Cerebellum (London, England)》2009,8(2):130-136
To assess heart rate (HR) regulation in Machado–Joseph disease (MJD), we evaluated HR variability at rest and the initial
HR response to standing suddenly in 13 MJD patients and 26 normal control subjects. A head-up tilt (HUT) test involving the
monitoring of blood pressure, HR, and cerebral oxy/deoxyhemoglobin concentration was also performed in each participant. There
was no significant difference in HR variability at rest between the two groups, but the transient HR rise just after standing
suddenly in the MJD group was significantly less than that in the control group (p < 0.01). The HUT test, where each participant was gradually tilted upward, induced a significantly greater HR increase in
the MJD group compared with the controls (p < 0.01), while there were no significant differences in the blood pressure and cerebral oxygenation changes between the two
groups. In our MJD study, the transient HR rise just after standing suddenly was diminished, and HR markedly increased during
sustained orthostatic stress. 相似文献
10.
Penuelas A Tashima K Tsuchiya S Matsumoto K Nakamura T Horie S Yano S 《European journal of pharmacology》2007,576(1-3):143-150