全文获取类型
收费全文 | 30977篇 |
免费 | 3246篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 222篇 |
儿科学 | 1063篇 |
妇产科学 | 1102篇 |
基础医学 | 4259篇 |
口腔科学 | 623篇 |
临床医学 | 3883篇 |
内科学 | 6427篇 |
皮肤病学 | 414篇 |
神经病学 | 2768篇 |
特种医学 | 931篇 |
外科学 | 3469篇 |
综合类 | 530篇 |
一般理论 | 50篇 |
预防医学 | 3895篇 |
眼科学 | 425篇 |
药学 | 2678篇 |
中国医学 | 14篇 |
肿瘤学 | 1535篇 |
出版年
2023年 | 222篇 |
2022年 | 293篇 |
2021年 | 614篇 |
2020年 | 433篇 |
2019年 | 696篇 |
2018年 | 741篇 |
2017年 | 607篇 |
2016年 | 647篇 |
2015年 | 640篇 |
2014年 | 900篇 |
2013年 | 1214篇 |
2012年 | 1772篇 |
2011年 | 1823篇 |
2010年 | 936篇 |
2009年 | 803篇 |
2008年 | 1439篇 |
2007年 | 1611篇 |
2006年 | 1447篇 |
2005年 | 1369篇 |
2004年 | 1333篇 |
2003年 | 1207篇 |
2002年 | 1167篇 |
2001年 | 809篇 |
2000年 | 854篇 |
1999年 | 729篇 |
1998年 | 317篇 |
1997年 | 263篇 |
1996年 | 272篇 |
1995年 | 275篇 |
1994年 | 242篇 |
1993年 | 238篇 |
1992年 | 563篇 |
1991年 | 575篇 |
1990年 | 559篇 |
1989年 | 544篇 |
1988年 | 500篇 |
1987年 | 505篇 |
1986年 | 461篇 |
1985年 | 427篇 |
1984年 | 377篇 |
1983年 | 300篇 |
1982年 | 233篇 |
1981年 | 192篇 |
1979年 | 289篇 |
1978年 | 282篇 |
1977年 | 202篇 |
1976年 | 203篇 |
1975年 | 199篇 |
1974年 | 214篇 |
1972年 | 205篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
Jennifer C. Sasaki Ashley Allemang Steven M. Bryce Laura Custer Kerry L. Dearfield Yasmin Dietz Azeddine Elhajouji Patricia A. Escobar Albert J. Fornace Jr Roland Froetschl Sheila Galloway Ulrike Hemmann Giel Hendriks Heng-Hong Li Mirjam Luijten Gladys Ouedraogo Lauren Peel Stefan Pfuhler Daniel J. Roberts Véronique Thybaud Jan van Benthem Carole L. Yauk Maik Schuler 《Environmental and molecular mutagenesis》2020,61(1):114-134
In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) framework. As AOPs are a relatively new approach in genetic toxicology, this report describes how AOPs could be harnessed to advance MOA analysis of genotoxicity pathways using five example case studies. Each of these genetic toxicology AOPs proposed for further development includes the relevant molecular initiating events, key events, and adverse outcomes (AOs), identification and/or further development of the appropriate assays to link an agent to these events, and discussion regarding the biological plausibility of the proposed AOP. A key difference between these proposed genetic toxicology AOPs versus traditional AOPs is that the AO is a genetic toxicology endpoint of potential significance in risk characterization, in contrast to an adverse state of an organism or a population. The first two detailed case studies describe provisional AOPs for aurora kinase inhibition and tubulin binding, leading to the common AO of aneuploidy. The remaining three case studies highlight provisional AOPs that lead to chromosome breakage or mutation via indirect DNA interaction (inhibition of topoisomerase II, production of cellular reactive oxygen species, and inhibition of DNA synthesis). These case studies serve as starting points for genotoxicity AOPs that could ultimately be published and utilized by the broader toxicology community and illustrate the practical considerations and evidence required to formalize such AOPs so that they may be applied to genetic toxicity evaluation schemes. Environ. Mol. Mutagen. 61:114–134, 2020. © 2019 Wiley Periodicals, Inc. 相似文献
7.
8.
9.
Joseph M. Northey Kate L. Pumpa Clare Quinlan Ashley Ikin Kellie Toohey Disa J. Smee Ben Rattray 《Journal of Science and Medicine in Sport》2019,22(5):580-585
Objectives
The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.Design
Pilot randomised-controlled trial.Methods
Seventeen female cancer survivors (mean: 62.9 ± 7.8 years) were randomised into three groups: high-intensity interval training (HIIT, n = 6); moderate-intensity continuous training (MOD, n = 5); or wait-list control (CON, n = 6). The HIIT and MOD groups exercised on a cycle ergometer 3 days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen’s d effect sizes were calculated.Results
All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7 ± 13.2% vs 79.4 ± 12.0%; p = 0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d = 1.28) and MOD had a non-significant 5.6% (d = 0.72) increase, compared to CON which had a 2.6% decrease.Conclusions
This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials. 相似文献10.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse
下载免费PDF全文
![点击此处可从《Addiction (Abingdon, England)》网站下载免费的PDF全文](/ch/ext_images/free.gif)