全文获取类型
收费全文 | 641篇 |
免费 | 37篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 39篇 |
妇产科学 | 3篇 |
基础医学 | 64篇 |
口腔科学 | 18篇 |
临床医学 | 47篇 |
内科学 | 156篇 |
皮肤病学 | 8篇 |
神经病学 | 10篇 |
特种医学 | 84篇 |
外科学 | 77篇 |
综合类 | 62篇 |
预防医学 | 23篇 |
眼科学 | 11篇 |
药学 | 32篇 |
肿瘤学 | 49篇 |
出版年
2023年 | 3篇 |
2022年 | 6篇 |
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 6篇 |
2017年 | 6篇 |
2016年 | 10篇 |
2015年 | 16篇 |
2014年 | 12篇 |
2013年 | 21篇 |
2012年 | 12篇 |
2011年 | 17篇 |
2010年 | 21篇 |
2009年 | 32篇 |
2008年 | 12篇 |
2007年 | 26篇 |
2006年 | 34篇 |
2005年 | 15篇 |
2004年 | 14篇 |
2003年 | 10篇 |
2002年 | 10篇 |
2001年 | 17篇 |
2000年 | 13篇 |
1999年 | 17篇 |
1998年 | 42篇 |
1997年 | 31篇 |
1996年 | 41篇 |
1995年 | 17篇 |
1994年 | 18篇 |
1993年 | 23篇 |
1992年 | 9篇 |
1991年 | 14篇 |
1990年 | 6篇 |
1989年 | 16篇 |
1988年 | 28篇 |
1987年 | 12篇 |
1986年 | 12篇 |
1985年 | 19篇 |
1984年 | 7篇 |
1983年 | 8篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1930年 | 1篇 |
1879年 | 1篇 |
排序方式: 共有685条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
Badalová J Svobodová M Havelková H Vladimirov V Vojtísková J Engová J Pilcík T Volf P Demant P Lipoldová M 《Genes and immunity》2002,3(4):187-195
The strain BALB/cHeA (BALB/c) is a high producer, and STS/A (STS) a low producer of IgE after Leishmania major infection. We analyzed this strain difference using 20 recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% of genes of the strain STS on the BALB/c background. Strains CcS-16 and -20 exhibit a high and a low IgE level, respectively. In their F(2) hybrids with BALB/c we mapped nine Leishmania major response (Lmr) loci. Two of them we previously found to influence IgE level in CcS-5. IgE production in CcS-16 is controlled by loci on chromosomes 2, 10, 16 and 18 and in CcS-20 by loci on chromosomes 1, 3, 4, 5 and 8. The STS alleles of loci on chromosomes 1, 4, 5, 8 and 10 were associated with a low, whereas the STS alleles on chromosomes 16 and 18 with a high IgE production. The loci on chromosomes 2 and 3 have no apparent individual effect, but interact with the loci on chromosomes 10 and 1, respectively. The loci on chromosomes 10 and 18 were mapped in the regions homologous with the human regions containing genes that control total serum IgE and intensity of infection by Schistosoma mansoni, suggesting that some Lmr loci may participate in the pathways influencing atopic reactions and responses to several parasites. The definition of genes controlling anti-parasite responses will permit a better understanding of pathways and genetic diversity underlying the disease phenotypes. 相似文献
10.
Bals-Pratsch M; De Geyter C; Muller T; Frieling U; Lerchl A; Pirke KM; Hanker JP; Becker-Carus C; Nieschlag E 《Human reproduction (Oxford, England)》1997,12(5):896-904
Preliminary data have suggested that female infertility due to corpus
luteum insufficiency may be caused by subclinical hypothyroidism
[exaggerated thyroid-stimulating hormone (TSH) response to thyrotrophin-
releasing hormone (TRH) stimulation]. L-Thyroxine supplementation has been
recommended to achieve pregnancies in subclinical hypothyroid women. This
controlled study was carried out in order to investigate the biochemical
diagnosis of subclinical hypothyroidism as a possible infertility factor.
Five infertile patients (aged 25-36 years) with subclinical hypothyroidism
(n = 4, stimulated TSH >20 microU/ml) or primary hypothyroidism (n = 1)
and five healthy controls (aged 22-39 years) with normal thyroid function
(stimulated TSH <15 microU/ml), regular cycles and no history of
infertility were studied in the early follicular phase. In the pre-study
evaluation, eight of 23 volunteers (34.8%) had to be excluded because of
subclinical hypothyroidism with stimulated TSH values (TSHs) >15
microU/ml. Cycle function of patients and controls was compared by the
method of LH pulse pattern analysis. Therefore blood samples were drawn
every 10 min during a 24 h period. Sleep was recorded from midnight to 7
a.m. Repetition of the TRH tests at the end of the 24 h blood sampling
period confirmed the difference in stimulated TSH values of the two study
groups. Pulse analysis for luteinizing hormone (LH), TSH and prolactin
showed no differences between patients and controls for pulse frequency,
amplitude, height, length, area under curve (AUC) and the 24 h mean. Even
the hypothyroid patient had a normal LH pulse pattern. Additional
measurement of melatonin in pooled sera every 30 min gave the
well-documented diurnal profiles during day and night for both groups.
Patients had significantly higher melatonin values at seven time points
during the night. Peaks for LH, TSH, prolactin and cortisol were correlated
with the sleep stages wake, rapid eye movement, 1 + 2 and 3 + 4. We
concluded that corpus luteum insufficiency in female infertility cannot be
explained by subclinical hypothyroidism and thus should not be treated with
L-thyroxine for fertility reasons.
相似文献