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JIN-SONG HE SATOSHI HORIKOSHI KAZUHIKO FUNABIKI ISAO SHIRATO YASUHIKO TOMINO 《Nephrology (Carlton, Vic.)》2002,7(2):83-86
SUMMARY: Inhibition of mevalonate synthesis by several statins has been shown to suppress DNA synthesis in glomerular mesangial cells. In the present study, we investigated the effect of a new statin, cerivastatin, on fetal calf serum (FCS)-induced DNA synthesis of cultured rat mesangial cells. Cultured rat mesangial cells were stimulated by 10% FCS in the presence or absence of cerivastatin and mevalonate. 5-bromo-2-deoxyuridine (BrdU) incorporation was used to assess DNA synthesis. the present study showed that 10% FCS caused marked stimulation of DNA synthesis in the mesangial cells. Cerivastatin inhibited FCS-stimulated BrdU incorporation in a dose-dependent manner. IC50 was approximately 1 umol/L. Exogenous mevalonate, farnesyl pyrophosphate and geranylgeranyl pyrophosphate significantly prevented the inhibitory effect of cerivastatin on DNA replication. It appears that cerivastatin, by inhibiting the synthesis of mevalonate, may suppress DNA synthesis in the mesangial cells. 相似文献
3.
IWAHASHI KAZUHIKO; NAKAMURA KAZUHIKO; SUWAKI HIROSHI; MATSUO YOSHINORI; ICHIKAWA YOSHIYUKI 《Alcohol and alcoholism (Oxford, Oxfordshire)》1994,29(6):639-642
In 45 healthy Japanese volunteers, it was found that personsheterozygous for ALDH2 (ALDH2*1/ALDH2*2), and also either heterozygousor mutant homozygous for CYP2E1 (C2/C2 or C1/C2 can drink muchmore alcohol, even with (slight) flushing, than persons heterozygousfor ALDH2 (ALDH2*1/ALDH2*2) and normal homozygous for CYP2E1(C1/C1) 相似文献
4.
YOSHIKI NISHIZAWA TAKEHISA FUJITA KAZUHIKO MATSUOKA HIROFUMI NAKAGAWA 《Pediatrics international》2006,48(5):484-488
BACKGROUND: Local force distribution supporting the bodyweight of infants with Down syndrome (DS) appears to be different from that of healthy controls. The purpose of the present study was to establish methods to assess this force distribution and to allow therapeutic evaluation of neurological development in DS infants prior to walking. METHODS: Contact pressure distribution patterns in supine and prone positions were measured by photoelastic methods and were compared between DS infants and healthy controls. The DS group included eight subjects, seven with regular trisomy 21, and one with a Robertson translocation. The controls consisted of 14 neonates, four 4-month-old infants and eight 7-month-old infants. RESULTS: In both groups, head loading ratio decreased as age advanced but the decrement was less in the test group than in the control group. When the bodyweight loading ratios were measured in two different lying positions, that is, prone and supine, the ratios for prone generally tended to be smaller than those for supine in the controls. This kind of difference between prone and supine was not seen in the DS group. The bodyweight is somewhat sustained with limbs and the limbs loading ratios in the DS group were always significantly lower than in the controls. CONCLUSION: Coordinated development of weight-supporting limbs seems to be poor in the DS group. 相似文献
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MOTOYUKI OHHIRA HITOYOSHI OHTA MASUMI OHHIRA AKINORI MATSUMOTO TAKAAKI OHTAKE YOSHINORI FUJIMOTO KAZUHIKO MURAZUMI MINORU ONO YUTAKA KOHGO 《Journal of gastroenterology and hepatology》1998,13(7):691-695
The object of this study was to determine the frequency and characteristics of altered paraumbilical vein in the hepatic parenchyma, developed from portal hypertension, using computed tomography (CT). Two hundred and ninety-two patients who presented with portal hypertension from 1986 to 1996 were studied retrospectively. The pathway of the dilated para-umbilical vein was demonstrated by contrast-enhanced CT. Thirty-one (11%) patients had a dilated para-umbilical vein arising from the left portal vein into the falciform ligament. In 24 (77%) of these patients, the para-umbilical vein followed the expected route, passing through the fissure of ligamentum teres hepatis. The remaining seven patients (23%) displayed the unusual pathway, with the vein arising from the left branch of the portal vein and passing into the hepatic parenchyma. In these seven patients, four had one collateral vein, and three patients had two collateral veins in the liver parenchyma. The dilated para-umbilical vein frequently passes through the hepatic parenchyma in patients with portal hypertension. 相似文献
7.
HIROSHI TAIRA TATSU ISHII YOSHIO INOUE YOSHIHARU HIRATSUKA 《International journal of urology》2005,12(1):96-97
Skeletal muscle is a very rare location for the metastasis of renal cell carcinoma (RCC) and only one case of solitary metastasis to the psoas muscle has been reported. We present a 63-year-old male patient with late recurrence (14 years) after left side radical nephrectomy for RCC. He first visited Chikushi Hospital, Fukuoka University, Japan in January 2000 for a postoperative follow-up because he had shifted residence to the area. Follow-up was by abdominal computed tomography (CT) and chest X-ray. In December 2001, a CT scan showed a 1.5 cm enhanced mass in the right psoas muscle without any other metastasis. The mass was resected that month and histological study showed RCC metastasis. 相似文献
8.
K. TANAKA M. TAIRA H. SHINTANI K. WAKASA M. YAMAKI 《Journal of oral rehabilitation》1991,18(4):353-362
Rods of a visible-light-cured dental composite resin were photo-polymerized and immersed in water at 37 degrees C for 7 days. The residual monomers (TEGDMA and Bis-GMA) trapped in the set composite and those eluted into water were analysed by gas-liquid chromatography. It became evident that minor amounts of the residual monomers dissolved in water, but that most residual monomers remained in the set composite. Extension of the irradiation period contributed to the significant reduction in the residual monomer level and its elution into water. 相似文献
9.
AKIRA HASEGAWA MASAKO HATORI MASAO AMANO TOHRU IIJIMA HITOSHI ADACHI ETSUO YAMAGUCHI TAKESATORU FUKUDA KAZUHIKO MURATA RYOZO NAGAI 《Pacing and clinical electrophysiology : PACE》1997,20(2):307-312
Our objective was to determint; the adequate pacing rate during exercise in ventricular pacing by measuring exercise capacity, cardiac output, and sinus node activity. Eighteen patients with complete AV block and an implanted pacemaker underwent cardiopulmonary exercise tests under three randomized pacing rates: fixed rate pacing (VVJ) at 60 beats/min and ventricular rate-responsive pacing (VVIR) programmed to attain a heart rate of about 110 beats/min ar 130 beats/min (VVIR 110 and VVIR 130, respectively) at the end of exercise. Compared with VVI and VVIR 130, VVIR 110 was associated with an increased peak oxygen uptake(VVIR 110:20.3 ± 4.5 vs VVI: 16.9 ± 3.1; P < 0.01; and VVIR 130: 19.0 ± 4.1 mL/min per kg, respectively; P < 0.05) and a higher oxygen uptake at anaerobic threshold (15.3 ± 2.7, 12.7 ± 1.9; P < 0.01, and 14.6 ± 2.6 mL/min per kg; P < 0.05). The atrial rate during exercise expressed as a percentage of the expected maximal heart rate was lower in VVIR 110 than in VVI or VVIR 130 (VVIR 110: 75.9%± 14.6% vs VVI: 90.6%± 12.8%; P < 0.01; VVIR 110 vs VVIR 130: 89.1%± 23.1%; P < 0.05). There was no significant difference in cardiac output at peak exercise between VVIR 110 and VVIR 130. We conclude that a pacing rate for submaximal exercise of 110 beats/min may be preferable to that of 130 beats/min in respect to exercise capacity and sympathetic nerve activity. 相似文献
10.
Sleep disorder in children with autism 总被引:1,自引:0,他引:1
Abstract Eighty-eight children with autism, living in a suburb of Tokyo, were examined by questionnaire from 21 July to 31 August. Experienced sleep disorders were observed in 56 children; 44 of whom had sleep disorders before 3 years old. The average age when sleep disorders were seen to have stopped was 5 years old. The most common problem was difficulty falling sleep ( n = 23), followed by frequent awakening during sleep time ( n = 19), then early morning awakening ( n = 11). Bed-wetting was observed in 22 children. 相似文献