肝癌化疗栓塞术后综合征临床分析

本文分析报告192例各型肝癌化疗栓塞术后综合征发生情况:总发生率为89.1%,转氨酶升高发生率为77.2%,肝区疼痛64.1%,发热54.2%,恶心呕吐35.4%,腹胀38.0%,腹水形成19.8%,黄疸18. 8%,呃逆5.7%.结合我们的研究和经验讨论了肝癌化疗栓塞的病理生理改变,化疗栓塞术后综合征发生机理及临床对症处理方法.     

VOWELS IN THE BUFFER: A CASE STUDY OF ACQUIRED DYSGRAPHIA WITH SELECTIVE VOWEL SUBSTITUTIONS

We report the case of a patient who recovered from a clinical picture of fluent aphasia to selective dysgraphia. The features of the writing disorder were compatible with a graphemic output buffer dysfunction (errors in all spelling tasks and for all type of material, affected by word length and consisting mostly of graphemic deviations), with the exception of the lack of transposition errors and position preference. Further, the spelling disorder was selective for vowels, replicating the original observation by Cubelli (1991). A similar, although milder, error pattern was also observed in reading tasks, in particular for nonwords, suggesting that the locus of dysfunction involves a processing stage shared by reading and writing. These findings support the notion that the consonant-vowel status is a property of graphemic representations, and is compatible with that a common buffer is involved in spelling and reading. We discuss the implications of selective vowel disorders for current models of the spelling system.     

How bilingualism protects the brain from aging: Insights from bimodal bilinguals

Bilingual experience can delay cognitive decline during aging. A general hypothesis is that the executive control system of bilinguals faces an increased load due to controlling two languages, and this increased load results in a more “tuned brain” that eventually creates a neural reserve. Here we explored whether such a neuroprotective effect is independent of language modality, i.e., not limited to bilinguals who speak two languages but also occurs for bilinguals who use a spoken and a signed language. We addressed this issue by comparing bimodal bilinguals to monolinguals in order to detect age‐induced structural brain changes and to determine whether we can detect the same beneficial effects on brain structure, in terms of preservation of gray matter volume (GMV), for bimodal bilinguals as has been reported for unimodal bilinguals. Our GMV analyses revealed a significant interaction effect of age × group in the bilateral anterior temporal lobes, left hippocampus/amygdala, and left insula where bimodal bilinguals showed slight GMV increases while monolinguals showed significant age‐induced GMV decreases. We further found through cortical surface‐based measurements that this effect was present for surface area and not for cortical thickness. Moreover, to further explore the hypothesis that overall bilingualism provides neuroprotection, we carried out a direct comparison of GMV, extracted from the brain regions reported above, between bimodal bilinguals, unimodal bilinguals, and monolinguals. Bilinguals, regardless of language modality, exhibited higher GMV compared to monolinguals. This finding highlights the general beneficial effects provided by experience handling two language systems, whether signed or spoken. Hum Brain Mapp 38:4109–4124, 2017. © 2017 Wiley Periodicals, Inc.     

Outcome of laparoscopic ventral hernia repair in correlation with obesity,type of hernia,and hernia size

BACKGROUND: The morbidity and overall recovery time of ventral hernia repair can vary significantly depending on the hernia type or size and on other factors, such as the body mass index (BMI). The purpose of our study was to investigate the effects of type of hernia, hernia size, and BMI on the outcome of laparoscopic ventral hernia repair. METHODS: Fifty patients who underwent laparoscopic ventral hernia repair were retrospectively reviewed and stratified according to hernia type (incisional, IVH/primary, PVH), hernia size, and BMI. These subgroups were compared in regard to operative time, resumption of diet, hospital stay, pain control, and complication rate. RESULTS: Laparoscopic IVH repair was associated with a longer operative time (143 vs. 98 minutes, p = .02) and length of stay (2.2 vs. 0.6 days, p = .03) than PVH repair. The narcotic requirements were higher in the IVH group, but the difference did not reach statistical significance. Larger hernias were associated with a longer operative time (p = .04) and increased narcotic requirement (p = .03). The morbidity of the laparoscopic repair was not significantly affected by the hernia type or size. The BMI did not significantly alter any of the parameters examined. CONCLUSIONS: Laparoscopic repair of incisional and larger hernias is a technically demanding procedure that requires a longer operative time. In contrast to PVH repair, laparoscopic IVH repair usually cannot be performed on an outpatient basis. Surgeons need not be discouraged from recommending the laparoscopic approach for patients with large IVHs or with severe obesity because the morbidity remains low.     

Die Behandlung der Psoriasis mit Cytostatica

Ohne Zusammenfassung     

Pathophysiology of language switching and mixing in an early bilingual child with subcortical aphasia

Acquired aphasia after circumscribed vascular subcortical lesions has not been reported in bilingual children. We report clinical and neuroimaging findings in an early bilingual boy who incurred equally severe transcortical sensory aphasia in his first language (L1) and second language (L2) after a posterior left thalamic hemorrhage. Following recurrent bleeding of the lesion the aphasic symptoms substantially aggravated. Spontaneous pathological language switching and mixing were found in both languages. Remission of these phenomena was reflected on brain perfusion SPECT revealing improved perfusion in the left frontal lobe and left caudate nucleus. The parallelism between the evolution of language symptoms and the SPECT findings may demonstrate that a subcortical left frontal lobe circuity is crucially involved in language switching and mixing.     

Successful treatment of severe cardiomyopathy with NTBC in a child with tyrosinaemia type I

Summary We report the case of a child who developed severe obstructive hypertrophic cardiomyopathy revealing hereditary tyrosinaemia type I, who was successfully treated with NTBC. The mechanisms underlying the association are discussed.     

Targeting hepatitis C virus translation: stopping HCV where it starts

Hepatitis C virus (HCV) infection is an emerging global health concern. Combination therapy with pegylated interferon-alpha (INF alpha) and ribavirin results in approximately 60% sustained recovery. Of the non-responders, the majority are infected with genotype 1. As a consequence, improved therapeutics are necessary to enhance response rates, especially in genotype-1-infected individuals. HCV translation is mediated by an internal ribosome entry site (IRES) located within the 5' non-translated region. Recent studies have revealed that the HCV IRES recruits the cellular translation machinery in a distinct manner compared with cellular mRNA strategies. Therefore, screening assays can be developed to identify specific inhibitors of HCV translation as a possible treatment for HCV.     

Structural Properties of the Lipid A Component of the Lipopolysaccharide(Endotoxin)Isolated from Bacteriodes fragilis NCTC 9343

Various chemical and gas-liquid chromatographic analyses indicate that the lipid A,backbone of the lipopolysaccharide(LPS)isolated from B.fragilis NCTC 9343 is chemically con-stitutεd by a β1,6-interlinked D-glucosamine disaccharide.It is phosphorylated at its 1-positionby a glvcosidic-linkage while the ester-linked phosphate at 4'—position present generally in otherlipid A is depleted.The lipid A is lower fatty acylated in the amount of 5.2 fatty acids/lipid Amolecule(of which 0.73 forms 3-acyloxyacyl groups).The LPS containing such an incompletelipid A component has been shown endowina with a weaker endotoxicitv.     

降糖固肾汤治疗糖尿病肾病的疗效观察

目的　观察降糖固肾汤对糖尿病肾病 (DN)的疗效。方法　 32例DN患者以自拟降糖固肾汤治疗 ,每日 1剂 ,1个月为 1疗程 ,3个疗程统计疗效。结果　显效 7例 ( 2 1.88% ) ,有效2 1例 ( 65.62 % ) ,无效 4例 ( 12 .50 % ) ,总有效率 87.50 %。空腹血糖由治疗前 ( 12 .19± 2 .75)mmol L ,下降至 ( 7.2 5± 1.51)mmol L ,尿白蛋白 ( 182 .35± 135.68)mg 2 4h ,下降至 ( 62 .0 9± 59.2 1)mg 2 4h ,治疗前后比较P <0 .0 1,临床症状亦有较大改善。结论　降糖固肾汤治疗糖尿病肾病疗效肯定。