全文获取类型
收费全文 | 1185篇 |
免费 | 362篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 39篇 |
妇产科学 | 93篇 |
基础医学 | 59篇 |
口腔科学 | 7篇 |
临床医学 | 732篇 |
内科学 | 151篇 |
皮肤病学 | 18篇 |
神经病学 | 183篇 |
特种医学 | 50篇 |
外科学 | 48篇 |
综合类 | 19篇 |
预防医学 | 78篇 |
眼科学 | 4篇 |
药学 | 32篇 |
中国医学 | 2篇 |
肿瘤学 | 40篇 |
出版年
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 17篇 |
2018年 | 73篇 |
2017年 | 101篇 |
2016年 | 117篇 |
2015年 | 106篇 |
2014年 | 93篇 |
2013年 | 118篇 |
2012年 | 59篇 |
2011年 | 54篇 |
2010年 | 77篇 |
2009年 | 96篇 |
2008年 | 77篇 |
2007年 | 68篇 |
2006年 | 50篇 |
2005年 | 54篇 |
2004年 | 50篇 |
2003年 | 28篇 |
2002年 | 31篇 |
2001年 | 21篇 |
2000年 | 20篇 |
1999年 | 19篇 |
1998年 | 17篇 |
1997年 | 23篇 |
1996年 | 19篇 |
1995年 | 14篇 |
1994年 | 13篇 |
1993年 | 8篇 |
1992年 | 6篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1958年 | 2篇 |
1955年 | 2篇 |
排序方式: 共有1560条查询结果,搜索用时 15 毫秒
1.
2.
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells 总被引:65,自引:10,他引:55
PADGEM protein (PADGEM), also known as GMP140, is a platelet alpha- granule membrane protein that is translocated to the external membrane after platelet activation. Although the biosynthesis of this protein was originally thought to be confined to megakaryocytes, the synthesis of PADGEM in endothelial cells was recently demonstrated (McEver et al: Blood 70:1974a, 1987). We now describe the subcellular localization of this protein in endothelial cells. Immunofluorescence staining of permeabilized human umbilical vein endothelial cells with KC4, a well characterized monoclonal antibody to PADGEM, showed positively stained elongated structures similar in distribution and shape to Weibel-Palade bodies. Their identity as Weibel-Palade bodies was confirmed by double label immunofluorescence using KC4 and a polyclonal antiserum to von Willebrand factor (vWf), a protein known to be specifically stored in these organelles. All Weibel-Palade bodies were found to contain PADGEM. In contrast to strong perinuclear staining produced with anti- vWf antibodies, no significant perinuclear staining was obtained with KC4, indicating that relatively little PADGEM is present in the endoplasmic reticulum and in the Golgi apparatus. In endothelial cells treated with secretagogues that stimulate vWf release the elongated structures positive for PADGEM disappeared, further identifying these structures as Weibel-Palade bodies. This observation extends the parallels between Weibel-Palade bodies and alpha-granules and suggests a possible functional association between vWf and PADGEM. 相似文献
3.
This column contains the presidential address presented during the Third Annual Meeting of the American Association of Heart Failure Nurses on June 28, 2007, in San Diego, California, titled "Building the Foundation of Excellence in Heart Failure Nursing." 相似文献
4.
5.
6.
Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer''s disease.
下载免费PDF全文
![点击此处可从《Journal of neurology, neurosurgery, and psychiatry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
K A Jobst A D Smith C S Barker A Wear E M King A Smith P A Anslow A J Molyneux B J Shepstone N Soper et al. 《Journal of neurology, neurosurgery, and psychiatry》1992,55(3):190-194
A combination of medial temporal lobe atrophy, shown by computed tomography, and reduced blood flow in the parietotemporal cortex, shown by single photon emission tomography, was found in 86% (44/51) of patients with a clinical diagnosis of senile dementia of the Alzheimer type (SDAT). The same combination of changes was found in four out of 10 patients with other clinical types of dementia and in two out of 18 with no evidence of cognitive deficit. Of the 12 patients who died, 10 fulfilled histopathological criteria for Alzheimer's disease, nine of them having a clinical diagnosis of SDAT, and one a clinical diagnosis of multi-infarct dementia. All 10 patients with histopathologically diagnosed Alzheimer's disease had shown a combination of hippocampal atrophy and reduced parietotemporal blood flow in life. In 10 patients (nine with SDAT) out of 12 in whom the hippocampal atrophy was more noticeable on one side of the brain than on the other the parietotemporal perfusion deficit was also asymmetrical, being greater on the side showing more hippocampal atrophy. These results suggest that the combination of atrophy of the hippocampal formation and reduced blood flow in the parietotemporal region is a feature of dementia of the Alzheimer type and that the functional change in the parietotemporal region might be related to the loss of the projection neurons in the parahippocampal gyrus that innervate this region of the neocortex. 相似文献
7.
8.
9.
K Jobst 《Orvosi hetilap》1986,127(48):2915-2919
10.