全文获取类型
收费全文 | 147541篇 |
免费 | 10952篇 |
国内免费 | 292篇 |
专业分类
耳鼻咽喉 | 1381篇 |
儿科学 | 3944篇 |
妇产科学 | 2995篇 |
基础医学 | 22870篇 |
口腔科学 | 3806篇 |
临床医学 | 12607篇 |
内科学 | 30113篇 |
皮肤病学 | 2498篇 |
神经病学 | 14677篇 |
特种医学 | 6202篇 |
外国民族医学 | 16篇 |
外科学 | 19103篇 |
综合类 | 649篇 |
现状与发展 | 1篇 |
一般理论 | 110篇 |
预防医学 | 15867篇 |
眼科学 | 2481篇 |
药学 | 8848篇 |
中国医学 | 261篇 |
肿瘤学 | 10356篇 |
出版年
2023年 | 647篇 |
2022年 | 964篇 |
2021年 | 2383篇 |
2020年 | 1760篇 |
2019年 | 2508篇 |
2018年 | 3103篇 |
2017年 | 2653篇 |
2016年 | 2902篇 |
2015年 | 3270篇 |
2014年 | 4341篇 |
2013年 | 5803篇 |
2012年 | 8868篇 |
2011年 | 8942篇 |
2010年 | 4654篇 |
2009年 | 4856篇 |
2008年 | 7982篇 |
2007年 | 8135篇 |
2006年 | 7872篇 |
2005年 | 7425篇 |
2004年 | 6342篇 |
2003年 | 6027篇 |
2002年 | 5494篇 |
2001年 | 4857篇 |
2000年 | 4799篇 |
1999年 | 4298篇 |
1998年 | 1838篇 |
1997年 | 1519篇 |
1996年 | 1566篇 |
1995年 | 1293篇 |
1994年 | 1214篇 |
1993年 | 1109篇 |
1992年 | 2935篇 |
1991年 | 2641篇 |
1990年 | 2516篇 |
1989年 | 2370篇 |
1988年 | 2153篇 |
1987年 | 1910篇 |
1986年 | 1826篇 |
1985年 | 1738篇 |
1984年 | 1246篇 |
1983年 | 1106篇 |
1982年 | 619篇 |
1981年 | 548篇 |
1980年 | 464篇 |
1979年 | 968篇 |
1978年 | 599篇 |
1977年 | 497篇 |
1974年 | 506篇 |
1973年 | 486篇 |
1972年 | 438篇 |
排序方式: 共有10000条查询结果,搜索用时 615 毫秒
1.
2.
Georg Prokop Benedikt Wiestler Daniel Hieber Fynn Withake Karoline Mayer Jens Gempt Claire Delbridge Friederike Schmidt-Graf Nicole Pfarr Bruno Märkl Jürgen Schlegel Friederike Liesche-Starnecker 《International journal of cancer. Journal international du cancer》2023,153(9):1658-1670
Intratumor heterogeneity is a main cause of the dismal prognosis of glioblastoma (GBM). Yet, there remains a lack of a uniform assessment of the degree of heterogeneity. With a multiscale approach, we addressed the hypothesis that intratumor heterogeneity exists on different levels comprising traditional regional analyses, but also innovative methods including computer-assisted analysis of tumor morphology combined with epigenomic data. With this aim, 157 biopsies of 37 patients with therapy-naive IDH-wildtype GBM were analyzed regarding the intratumor variance of protein expression of glial marker GFAP, microglia marker Iba1 and proliferation marker Mib1. Hematoxylin and eosin stained slides were evaluated for tumor vascularization. For the estimation of pixel intensity and nuclear profiling, automated analysis was used. Additionally, DNA methylation profiling was conducted separately for the single biopsies. Scoring systems were established to integrate several parameters into one score for the four examined modalities of heterogeneity (regional, cellular, pixel-level and epigenomic). As a result, we could show that heterogeneity was detected in all four modalities. Furthermore, for the regional, cellular and epigenomic level, we confirmed the results of earlier studies stating that a higher degree of heterogeneity is associated with poorer overall survival. To integrate all modalities into one score, we designed a predictor of longer survival, which showed a highly significant separation regarding the OS. In conclusion, multiscale intratumor heterogeneity exists in glioblastoma and its degree has an impact on overall survival. In future studies, the implementation of a broadly feasible heterogeneity index should be considered. 相似文献
3.
4.
5.
6.
Whitney S. Brandt Wanpu Yan Jian Zhou Kay See Tan Joseph Montecalvo Bernard J. Park Prasad S. Adusumilli James Huang Matthew J. Bott Valerie W. Rusch Daniela Molena William D. Travis Mark G. Kris Jamie E. Chaft David R. Jones 《The Journal of thoracic and cardiovascular surgery》2019,157(2):743-753.e3
Objective
Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non–small cell lung cancer has not been extensively studied.Methods
Patients with cT2-4N0-1M0 non–small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan–Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching.Results
In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response.Conclusions
Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non–small cell lung cancer who undergo complete surgical resection. 相似文献7.
8.
9.
10.
Interprofessional collaboration and communication in nursing homes: a qualitative exploration of problems in medical care for nursing home residents – study protocol
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)