全文获取类型
收费全文 | 206515篇 |
免费 | 4735篇 |
国内免费 | 470篇 |
专业分类
耳鼻咽喉 | 2855篇 |
儿科学 | 7825篇 |
妇产科学 | 6067篇 |
基础医学 | 27747篇 |
口腔科学 | 5890篇 |
临床医学 | 16281篇 |
内科学 | 37419篇 |
皮肤病学 | 4911篇 |
神经病学 | 12587篇 |
特种医学 | 11105篇 |
外国民族医学 | 97篇 |
外科学 | 30572篇 |
综合类 | 1116篇 |
一般理论 | 1篇 |
预防医学 | 16976篇 |
眼科学 | 4444篇 |
药学 | 14364篇 |
2篇 | |
中国医学 | 181篇 |
肿瘤学 | 11280篇 |
出版年
2018年 | 3867篇 |
2017年 | 4098篇 |
2016年 | 3428篇 |
2015年 | 5132篇 |
2014年 | 4597篇 |
2013年 | 3837篇 |
2012年 | 10664篇 |
2011年 | 5597篇 |
2010年 | 2599篇 |
2009年 | 4139篇 |
2008年 | 2811篇 |
2007年 | 3568篇 |
2006年 | 3769篇 |
2005年 | 11856篇 |
2004年 | 13274篇 |
2003年 | 8817篇 |
2002年 | 4007篇 |
2001年 | 4522篇 |
2000年 | 1846篇 |
1999年 | 5948篇 |
1998年 | 572篇 |
1995年 | 418篇 |
1992年 | 6900篇 |
1991年 | 7142篇 |
1990年 | 7371篇 |
1989年 | 6993篇 |
1988年 | 6495篇 |
1987年 | 6262篇 |
1986年 | 5980篇 |
1985年 | 5277篇 |
1984年 | 3621篇 |
1983年 | 2933篇 |
1982年 | 1025篇 |
1981年 | 789篇 |
1980年 | 848篇 |
1979年 | 3855篇 |
1978年 | 2393篇 |
1977年 | 1804篇 |
1976年 | 1576篇 |
1975年 | 2496篇 |
1974年 | 3140篇 |
1973年 | 2771篇 |
1972年 | 2781篇 |
1971年 | 2762篇 |
1970年 | 2575篇 |
1969年 | 2481篇 |
1968年 | 2250篇 |
1967年 | 2190篇 |
1966年 | 1906篇 |
1965年 | 1140篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
6.
Attachment is a behavioral and physiological system, which enables individual’s dynamic adaptation to its environment. Attachment develops in close interaction between an infant and his/her mother, plays an important role in the development of the infant’s brain, and influences the quality of interpersonal relationships throughout life.Security of attachment is believed to influence individual response to stress, exposing insecurely organized individuals to deregulated autonomic nervous system and exaggerated hypothalamic-pituitary-adrenal activity, which, in turn, produces increased and prolonged exposure to stress-hormones. Such stress responses may have considerable implications for the development of diverse health-risk conditions, such as insulin resistance and hyperlipidemia, shown by numerous studies.Although the mechanisms are not yet fully understood, there is compelling evidence highlighting the role of psychological stress in the development of type 1 diabetes (T1D). One of the possible contributing factors for the development of T1D may be the influence of attachment security on individual stress reactivity. Thus, the suggestion is that insecurely attached individuals are more prone to experience increased and prolonged influence of stress hormones and other mechanisms causing pancreatic beta-cell destruction.The present paper opens with a short overview of the field of attachment in children, the principal attachment classifications and their historic development, describes the influence of attachment security on individual stress-reactivity and the role of the latter in the development of T1D. Following is a review of recent literature on the attachment in patients with T1D with a conclusion of a proposed role of attachment organization in the etiology of T1D. 相似文献
7.
Torbj?rn Karlsson 《Upsala journal of medical sciences》2015,120(4):257-262
Background. Haemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by fever, hepatosplenomegaly, cytopenia, and progressive multiple-organ failure. HLH in adults is often secondary to autoimmune diseases, cancer, or infections in contrast to familial HLH. Treatment of secondary HLH is directed against the triggering disease in addition to immunosuppressive therapy, the latter commonly according to the HLH-2004 protocol.Methods. We conducted a retrospective study to identify triggering diseases, disease-specific and immunosuppressive therapy administered, and prognosis in adult patients with secondary HLH. Patient data were collected from October 2010 to January 2015.Results. Ten adult patients with secondary HLH were identified. Seven were men, and the median age at diagnosis was 62 years. Five cases were triggered by malignant disease and five by infection. The median patient fulfilled five of the eight HLH-2004 diagnostic criteria. All patients fulfilled the criteria fever, cytopenia, and ferritin >500 µg/L. Median time from hospital admission to HLH diagnosis was 20 days. Four patients received immunosuppressive therapy according to the HLH-2004 protocol. The prognosis was dismal, especially for the patients with malignancy-associated HLH, of whom all died.Conclusion. HLH should be suspected in patients who present with fever, cytopenia, and ferritin >500 µg/L. Secondary HLH has a dismal prognosis. None of the patients with HLH triggered by malignancy survived. Achieving remission of the triggering disease seems to be important for a favourable outcome as, in all surviving patients, the haemophagocytic syndrome resolved after remission of the underlying infection. 相似文献
8.
9.
Marta López-Fauqued Laura Campora Frédérique Delannois Mohamed El Idrissi Lidia Oostvogels Ferdinandus J. De Looze Javier Diez-Domingo Thomas C. Heineman Himal Lal Janet E. McElhaney Shelly A. McNeil Wilfred Yeo Fernanda Tavares-Da-Silva 《Vaccine》2019,37(18):2482-2493
Background
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.Methods
Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Safety analyses were performed on the pooled total vaccinated cohort, consisting of participants receiving at least one dose of RZV or placebo. Solicited and unsolicited adverse events (AEs) were collected for 7 and 30?days after each vaccination, respectively. Serious AEs (SAEs) were collected from the first vaccination until 12?months post-last dose. Fatal AEs, vaccination-related SAEs, and potential immune-mediated diseases (pIMDs) were collected during the entire study period.Results
Safety was evaluated in 14,645 RZV and 14,660 placebo recipients. More RZV than placebo recipients reported unsolicited AEs (50.5% versus 32.0%); the difference was driven by transient injection site and solicited systemic reactions that were generally seen in the first week post-vaccination. The occurrence of overall SAEs (RZV: 10.1%; Placebo: 10.4%), fatal AEs (RZV: 4.3%; Placebo: 4.6%), and pIMDs (RZV: 1.2%; Placebo: 1.4%) was balanced between groups. The occurrence of possible exacerbations of pIMDs was rare and similar between groups. Overall, except for the expected local and systemic symptoms, the safety results were comparable between the RZV and Placebo groups irrespective of participant age, gender, or race.Conclusions
No safety concerns arose, supporting the favorable benefit-risk profile of RZV. 相似文献10.
Frédéric Janvier Deborah Delaune Thomas Poyot Eric Valade Audrey Mérens Pierre E. Rollin Vincent Foissaud 《Emerging infectious diseases》2016,22(2):292-294
We evaluated RNA stability of Ebola virus in EDTA blood and urine samples collected from infected patients and stored in West Africa’s environmental conditions. In blood, RNA was stable for at least 18 days when initial cycle threshold values were <30, but in urine, RNA degradation occurred more quickly. 相似文献