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CO2 laser surgery of oral premalignant lesions 总被引:1,自引:0,他引:1
H H Horch K L Gerlach H E Schaefer 《International journal of oral and maxillofacial surgery》1986,15(1):19-24
Experiences gained in the CO2 laser treatment of patients with oral dysplastic precancerous lesions are presented. Besides 7 lichens planus, 50 leukoplakias of all grades of dysplasia, and carcinoma in situ and one lentigo maligna were removed superficially with a defocused laser. Within the average follow-up period of 37 months, 22% local recurrences were observed. In comparison with conservative drug therapy, conventional surgical procedures, and cryosurgical therapy, the CO2 laser treatment of multicentric premalignant diseases of the oral mucosa can be recommended as an alternative therapy. 相似文献
3.
H. -H. Horch 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1987,372(1):879-879
Zusammenfassung Heute betreffen ca. 40 bis 45% aller Gesichtsschädelfrakturen das Mittelgesicht, wobei als häufigste Ursachen Verkehrsunfälle und Rohheitsdelikte zu nennen sind. Die Klassifikation der Mittelgesichtsfrakturen erfolgt in zentrale Mittelgesichtsfrakturen (Le Fort I und II), zentrolaterale Frakturen (Le Fort III) und laterale Mittelgesichtsfrakturen (Jochbein-Jochbogenfrakturen). Das Behandlungsprinzip besteht darin, nach Reposition der Knochenfragmente 1. die korrekte Occlusion und die Kontinuität der Mittelgesichtspfeiler zu erhalten oder wiederherzustellen und 2. die reponierten Fragmente an den cranial angrenzenden und intakten Knochenstrukturen zu fixieren. Die Fixation erfolgt durch intraorale Schienenverbände, fronto-maxilläre oder zygomaticomaxilläre Aufhängung sowie Miniplattenosteosynthesen. Bei Beachtung dieser Prinzipien können in der überwiegenden Anzahl der Fälle funktionell und ästhetisch zufriedenstellende Ergebnisse erreicht werden. 相似文献
4.
Lawrence SM Larsen JO Horch KW Riso R Sinkjaer T 《Journal of biomedical materials research》2002,63(5):501-506
Polymer-based longitudinal intrafascicular electrodes (polyLIFEs) were chronically implanted into the sciatic nerve of white New Zealand rabbits (n=8) for a period of 6 months (hereafter referred to as the long-term group). The impact of the implantation procedure, as observed 6 months post surgery, was evaluated in a sham-treated control group (n=9). The contralateral sciatic nerve served as the control for each animal. Nerve-fiber counts, fiber diameters, and myelin thickness were estimated at the level of the implant site, 1.5 cm proximally, and 1.5 cm distally for both nerves in sham-treated and long-term groups. Implantation of polyLIFEs had no significant effect on fiber counts, nerve-fiber diameter, or myelin thickness. A slight increase in connective tissue in the vicinity of the implant site was evident in the long-term group, including a thin but dense capsule immediately surrounding the implanted electrode. 相似文献
5.
Identification of a new locus for autosomal dominant non-syndromic hearing impairment (DFNA7) in a large Norwegian family 总被引:3,自引:0,他引:3
Fagerheim T; Nilssen O; Raeymaekers P; Brox V; Moum T; Elverland HH; Teig E; Omland HH; Fostad GK; Tranebjaerg L 《Human molecular genetics》1996,5(8):1187-1191
Hereditary hearing impairment affects about 1 in 1000 newborns. In most
cases hearing loss is non-syndromic with no other clinical features, while
in other families deafness is associated with specific clinical
abnormalities. Analysis of large families with non-syndromic and syndromic
deafness have been used to identify genes or gene locations that cause
hearing impairment. The present report describes a large Norwegian family
with autosomal dominant non-syndromic, progressive high tone hearing loss
with linkage to 1q21-q23. A maximum LOD score of 7.65 (theta = 0.00) was
obtained with the microsatellite marker D1S196. Analysis of recombinant
individuals maps the deafness gene (DFNA7) to a 22 cM region between D1S104
and D1S466. The region contains several attractive candidate genes. This
report supports the idea of extensive genetic heterogeneity in hereditary
hearing impairment and represents the first localization of a deafness gene
in a Norwegian family.
相似文献
6.
Horch RE Andree C Kopp J Tánczos E Voigt M Bannasch H Walgenbach KJ Dai FP Bittner K Galla TJ Stark GB 《Zentralblatt für Chirurgie》2000,125(Z1):74-78
A variety of reasons can afflict wound healing. Current research is focussed on the acceleration of wound healing by stimulating molecular processes. Gene therapy may offer completely new ways to treat chronic wounds. Possible advantages of gene therapeutic modulation of wound healing might be a long term efficiency, systemic or local regulation of gene expression and low side-effects. Current goals comprise the improvement of transfection efficiency and specificity. In vivo applications are therefore focussed on optimized inducible or even cell-type specific promotors, as well as on improved local application techniques. Studies from our laboratory demonstrate the possibility to combine modern cell culture techniques with different types of gene transfer. This enables the simultaneous grafting of manipulated cells to the wound with the continuous delivery of specific proteins of interest. Experimentally, this lead to accelerated closure of partial and full thickness animal wounds. Clinically, gene therapy for the treatment of chronic wounds seems to be a realistic goal within the next years and might be applicable for a variety of novel indications. 相似文献
7.
Two girls (a 5 year old and a 21 month old) experiencing mononucleosis syndrome with coincidental human herpesvirus (HHV)-7 and Epstein-Barr virus (EBV) infections are described. One patient had primary HHV-7 infection and reactivated EBV infection. The other had primary HHV-7 and EBV infections. These cases indicated that HHV-7 is capable of inducing infectious mononucleosis-like illness. Multiple herpesvirus infection in one of the patients also suggests that interaction among herpesviruses can occur in vivo. The consequence of this interaction may have clinical implications. 相似文献
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10.
Negative pressure wound treatment with computer‐controlled irrigation/instillation decreases bacterial load in contaminated wounds and facilitates wound closure 下载免费PDF全文
Ingo Ludolph Frederik W Fried Katharina Kneppe Andreas Arkudas Marweh Schmitz Raymund E Horch 《International wound journal》2018,15(6):978
Microbial wound contamination is known to be a hindrance to wound healing. Negative pressure wound therapy (NPWT) with or without irrigation is known to optimise conditions in problem wounds. The aim of this study was to investigate the influence of computer‐controlled wound irrigation with NPWT on the bacterial load in contaminated wounds. A total of 267 patients were treated with NPWT with automated instillation because of problematic wounds using an antiseptic instillation solution. In 111 patients, a minimum of 4 operative procedures were necessary, and swabs were taken at least at the first and at the fourth operation in a standardised procedure. The number of different bacteria and the amount of bacteria were analysed during the course. In a subgroup of 51 patients, swabs were taken at all 4 operative procedures and analysed separately. In an overall analysis, the number of different bacteria and the amount of bacteria significantly decreased independent of wound localisation and diagnosis. NPWT with automated instillation demonstrates a positive influence in the reduction of bacterial load in problem wounds. Thus, it may help to optimise wound conditions before definite wound closure. 相似文献