全文获取类型
收费全文 | 1933篇 |
免费 | 112篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 17篇 |
妇产科学 | 13篇 |
基础医学 | 327篇 |
口腔科学 | 41篇 |
临床医学 | 160篇 |
内科学 | 477篇 |
皮肤病学 | 75篇 |
神经病学 | 179篇 |
特种医学 | 88篇 |
外科学 | 253篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 60篇 |
眼科学 | 22篇 |
药学 | 192篇 |
中国医学 | 24篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 8篇 |
2022年 | 32篇 |
2021年 | 61篇 |
2020年 | 30篇 |
2019年 | 50篇 |
2018年 | 60篇 |
2017年 | 43篇 |
2016年 | 65篇 |
2015年 | 80篇 |
2014年 | 113篇 |
2013年 | 117篇 |
2012年 | 179篇 |
2011年 | 198篇 |
2010年 | 121篇 |
2009年 | 112篇 |
2008年 | 149篇 |
2007年 | 119篇 |
2006年 | 110篇 |
2005年 | 102篇 |
2004年 | 90篇 |
2003年 | 70篇 |
2002年 | 78篇 |
2001年 | 10篇 |
2000年 | 14篇 |
1999年 | 15篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 2篇 |
1995年 | 7篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1967年 | 1篇 |
1964年 | 1篇 |
1934年 | 2篇 |
1933年 | 2篇 |
排序方式: 共有2088条查询结果,搜索用时 15 毫秒
1.
Ho-Chul Jung Sung-Bin Chon Won Sup Oh Dong-Hyun Lee Ho-Jin Lee 《The American journal of tropical medicine and hygiene》2015,92(2):256-261
Scrub typhus usually presents as acute undifferentiated fever. This cross-sectional study included adult patients presenting with acute undifferentiated fever defined as any febrile illness for ≤ 14 days without evidence of localized infection. Scrub typhus cases were defined by an antibody titer of a ≥ fourfold increase in paired sera, a ≥ 1:160 in a single serum using indirect immunofluorescence assay, or a positive result of the immunochromatographic test. Multiple regression analysis identified predictors associated with scrub typhus to develop a prediction rule. Of 250 cases with known etiology of acute undifferentiated fever, influenza (28.0%), hepatitis A (25.2%), and scrub typhus (16.4%) were major causes. A prediction rule for identifying suspected cases of scrub typhus consisted of age ≥ 65 years (two points), recent fieldwork/outdoor activities (one point), onset of illness during an outbreak period (two points), myalgia (one point), and eschar (two points). The c statistic was 0.977 (95% confidence interval = 0.960–0.994). At a cutoff value ≥ 4, the sensitivity and specificity were 92.7% (79.0–98.1%) and 90.9% (86.0–94.3%), respectively. Scrub typhus, the third leading cause of acute undifferentiated fever in our region, can be identified early using the prediction rule. 相似文献
2.
Eun Yeon Joo Jee Hyun Kim Woo Suk Tae Sun Jung Han Seunghwan Kim Myoung-Hee Kim Hong Sik Byun Seung Bong Hong 《Journal of neuroimaging》2004,14(4):365-368
A patient with chronic cerebral paragonimiasis began to have new motor seizures of the right face manifested by clonic contractions that occurred several hundred times a day, consistent with simple partial status epilepticus. Ictal electroencephalogram discharges started from the left frontal region and then spread to the left hemisphere with left frontal maximum. But clinical seizures were limited to the right face. The frequent partial seizures were controlled by the intravenous infusion of phenytoin. Brain magnetic resonance imaging showed multiple conglomerated round nodules with encephalomalacia in the left temporal and occipital lobes. Applying the technique of ictal-interictal single-photo emission computed tomography subtraction, the authors were able to localize the focal ictal-hyperperfusion on left precentral cortex adjacent to the lesions that correspond to the anatomical distribution of left face motor area. 相似文献
3.
Enhancement of hepatic hemangiomas with levovist on coded harmonic angiographic ultrasonography. 总被引:5,自引:0,他引:5
Jung Hoon Kim Tae Kyoung Kim Bong Soo Kim Hyo Won Eun Pyo Nyun Kim Moon-Gyu Lee Hyun Kwon Ha 《Journal of ultrasound in medicine》2002,21(2):141-148
OBJECTIVE: To evaluate the pattern of contrast enhancement with Levovist on coded harmonic angiographic ultrasonography of hepatic hemangiomas. METHODS: Twenty hemangiomas were evaluated with coded harmonic angiographic ultrasonography and a microbubble contrast agent. Verification of the diagnosis of a hemangioma was made by means of dynamic computed tomography (n = 8), dynamic magnetic resonance imaging (n = 1), radionuclide scanning (n = 6), or follow-up ultrasonography (n = 5). Ultrasonographic images were obtained before contrast agent administration and with a bolus injection of 2.5 g of a microbubble contrast agent (300 mg/mL Levovist; Schering AG, Berlin, Germany) every 10 to 15 seconds for 5 minutes. The contrast enhancement patterns of the 20 hemangiomas were assessed. RESULTS: The tumor diameters as measured on ultrasonography were 7 to 97 mm (mean, 26.7 mm). Of the 20 hemangiomas, peripheral globular enhancement with progressive centripetal fill-in was shown in 15 (75%), rimlike enhancement with progressive centripetal fill-in was shown in 2 (10%), and homogeneous enhancement was shown in 1 (5%). In the remaining 2 lesions (10%), the enhancement patterns could not be seen, because they were not found on coded harmonic angiographic ultrasonography. CONCLUSIONS: Coded harmonic angiographic ultrasonography with a microbubble contrast agent can depict the typical enhancement pattern in most hepatic hemangiomas. 相似文献
4.
Yoshihide Nagasako Meang Bong Jin Hiroshi Miyazaki Masato Nakayama Tsuyoshi Shimamura Hiroyuki Furukawa Michiaki Matushita Satoru Todo 《Liver transplantation》2006,12(3):435-439
Thrombocytopenia is a frequent finding following living donor hepatectomy. It appears more pronounced in right graft donors than in left graft donors. This study analyzed postoperative thrombocytopenia in 20 living liver donors and examined the change of endogenous thrombopoietin (TPO) in its recovery. Platelet count, TPO level, fibrinogen degradation product (FDP), and D-Dimer were measured before surgery and on postoperative days (PODs) 1, 2, 3, 5, 7, and 14. Concurrently, liver and spleen volumes were calculated by computed tomography. Platelet count on POD 3 was significantly lower in right graft donors than in left graft donors (13.0 +/- 3.7 x 10(4)/microL vs. 16.8 +/- 4.0 x 10(4)/microL, P = 0.039) but recovered by POD 7 in all donors. Postoperative elevations of FDP and D-Dimer were significantly higher in right graft donors than in left graft donors. TPO level rose immediately after surgery, peaked on POD 5 in left graft donors and on POD 7 in right graft donors, and fell nearly to preoperative levels by POD 14. Postoperative TPO level per liver volume was significantly higher in right graft donors than in left graft donors. In conclusion, thrombocytopenia following living donor hepatectomy resolved within the first week regardless of graft type and was mainly associated with increasing consumption of circulating platelets, possibly due to intrahepatic and splenic congestion. With a reduced number of circulating platelets, TPO level rapidly increases. Also, with reduced consumption of platelets related to recovery from surgery, thrombocytopenia should resolve. As a consequence, TPO level would be expected to fall. 相似文献
5.
6.
前列腺癌及其癌前病变的细胞核形态特征与DNA含量的定量研究 总被引:1,自引:0,他引:1
应用计算机图像分析技术,对30例前列腺癌(PC)和30例前列腺非典型增生(PD)的石蜡包埋标本进行了核形态定量参数、DNA含量的定量测定。结果显示:PD的核面积明显高于正常细胞而低于PC(P<0.01)。三级PD之间,两两相比有非常显著性差异(P<0.01)。PD3与PC1的核面积有明显交叉,说明PD3具有PC的某些特征。正常前列腺上皮细胞与PD细胞核DNA含量及倍体分布近似。PD1~PD3细胞核DNA含量均值呈递增现象。PC组织分化程度越低,细胞核DNA含量增高越显著,2C和4C细胞越少,呈明显相关关系。提示DNA含量变化与前列腺癌和癌前病变的细胞分化异常密切相关。 相似文献
7.
Purification and characterization of a 43-kilodalton extracellular serine proteinase from Cryptococcus neoformans 总被引:3,自引:0,他引:3
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
An extracellular proteinase was purified from culture filtrates of Cryptococcus neoformans NHPY24 by DEAE ion-exchange chromatography and gelatin affinity column chromatography with azoalbumin as the substrate. The molecular mass of the purified enzyme was 43 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, its pH optimum was 7.0 to 8.0, and maximal activity was obtained at pH 7.5 and 37 degrees C. By isoelectric focusing, the purified enzyme had a pI of 4.77. Enzyme activity was inhibited by serine proteinase inhibitors such as phenylmethylsulfonyl fluoride and diisopropylfluorophosphate. The purified enzyme was thus a serine proteinase. It hydrolyzed natural substrates including hemoglobin, beta-casein, and gamma globulin. 相似文献
8.
Bong Hyo Lee Rong Jie Zhao Jin Young Moon Seong Shoon Yoon Jung-Ae Kim Heeduk An Young Kyu Kwon Meeyul Hwang Seong Hun Choi Insop Shim Bong Hyun Kim Chae Ha Yang 《Neuroscience letters》2008
In our previous study we demonstrated that acupuncture at Shenmen (HT7) points suppressed a decrease of accumbal dopamine (DA) release in ethanol-withdrawn rats. Furthermore, here we found that it inhibited behavioral withdrawal signs of ethanol. In an effort to better understand the mechanisms underlying this inhibition, the potential role of GABA receptor system in acupuncture was investigated. Male Sprague–Dawley rats were treated with 3 g/kg/day of ethanol (20%, w/v) or saline by intraperitoneal injection for 21 days. Following 48 or 72 h of ethanol withdrawal, acupuncture was applied at bilateral HT7 for 1 min. The selective GABAA antagonist bicuculline and the selective GABAB antagonist SCH 50911 were injected intraperitoneally 20 min before acupuncture, respectively. Importantly, suppressive effects of acupuncture on DA deficiency were completely abolished by SCH 50911, but not by bicuculline, whereas ameliorating effects of acupuncture on ethanol withdrawal syndrome were completely blocked either by SCH 50911 or bicuculline. These results suggest that acupuncture at specific acupoint HT7 may normalize the DA release in the mesolimbic system and attenuate withdrawal syndrome through the GABAB receptor system in ethanol-withdrawn rats. 相似文献
9.
Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Spinola SM Bong CT Faber AL Fortney KR Bennett SL Townsend CA Zwickl BE Billings SD Humphreys TL Bauer ME Katz BP 《Infection and immunity》2003,71(11):6658-6663
With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model. 相似文献
10.
Yukio Nagasaki Sang Bong Han Masao Kato Teiji Tsuruta 《Macromolecular chemistry and physics.》1992,193(7):1633-1641
Radical copolymerization of 4-(trimethylsilyl)styrene (TMSS) with styrene were carried out to estimate the reactivity of TMSS. The monomer reactivity ratios r1 and r2 in the radical copolymerization of TMSS (M1) with styrene (M2) were evaluated as 0,28 and 0,48, respectively. The value r1 · r2 (= 0,13) being smaller than unity indicates that the trimethylsilyl group at para position behaves as an electron-withdrawing substituent. Reactions of lithium diethylamide with TMSS in the presence of diethylamine, gave the 1:1 addition product 1-[2-(N,N-diethylamino)-ethyl]-4-(trimethylsilyl)benzene. Kinetic analysis showed that the second-order rate constant (k) for this addition reaction is 34,4 · 10?4 dm3 · mol?1 · s?1, which is by a factor of 2 larger than that for the reaction with styrene (k = 16,0 · 10?4 dm3 · mol?1 · s?1). The fact is also compatible with the above consideration for the r1 · r2 values. Lithium diisopropylamide initiated anionic copolymerizations of TMSS with 1,4-divinylbenzene (DVB) were also examined. The polymerizations proceed smoothly without any gel formation and the resulting copolymers are soluble in various common solvents such as benszene, tetrahydrofuran, chloroform, etc. Thus, novel organosilicon-containing polymers having appropriate amounts of reactive pendent vinyl groups are easily synthesized. 相似文献