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Paketci Cem Edem Pinar Okumus Canan Sarioglu Fatma Ceren Bayram Erhan Hiz Semra Yis Uluç 《Journal of neurovirology》2020,26(2):270-272
Journal of NeuroVirology - Acute cerebellitis is one of the most common cerebellar disorders and occurs due to para-infectious, post-infectious, or post-vaccination cerebellar inflammation. Herpes... 相似文献
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Aksu N Seyahi A Aksu T Oztürk C Dervişoğlu S Murat Hiz VM 《Archives of orthopaedic and trauma surgery》2008,128(10):1187-1191
Introduction Chemical and physical effects of cementation cause radiographic and histological changes at bone-cement interface. These changes
can be of interest in the assessment of the residual lesions and subsequent recurrences after local resection and cementation
of local aggressive tumours.
Aim The aim of the study was to evaluate the evolution and determine the stages of the changes that occur at the bone-cement interface
after cementation of cavitary lesions.
Material and methods We operated on 16 hind legs of 8 sheep (Ovies Aries) under general anaesthesia (Xylasin HCl, Ketamin HCl and Forane). A bone
cavity of 12 cm3 was produced by curettage of the distal femoral condyle and was filled with cement. Control radiographs were taken at 2 days;
3, 6 and 12 weeks, and again at 6 months. One sheep each time was killed after second day and sixth month and two sheep each
time after the third, sixth and 12th week and the specimens underwent pathological examination.
Results After the first 3 weeks, a reactive fibrous membrane was detected on pathological examinations. This membrane consisted of
granulation tissue, necrotic bone and bone marrow, which were replaced gradually by fibrous tissue. The radiographic revelation
of this fibrous membrane was a radiolucent zone of 0.5–1.5 mm at 3 weeks. A Sclerotic rim appeared around this radiolucent
zone at 6 weeks. With new bone formation the fibrous membrane disappeared at 3 months. This was seen on radiographs as the
replacement of the radiolucent zone by a sclerotic ring of 0.5–2 mm. This sclerotic ring disappeared at 6 months, when a diffuse
sclerosis and cortical bone thickening was detected on radiographs.
Discussion According to our findings we suggest to consider the pathological processes at the bone-cement interface in 3 phases: (1)
Reactive phase (first 3 weeks); (2) Resorption phase (3–6 weeks), and (3) Formation phase (6 weeks to 6 months). We have distinguished
five different radiographic stages: Stage 1—Early stage with no apparent zone (first 3 weeks); Stage 2—Radiolucent zone (3–6 weeks);
Stage 3—Radiolucent zone with a sclerotic rime (6 weeks to 3 months); Stage 4—sclerotic ring (after 3 months) and Stage 5—Diffuse
cortical thickening (after 6 months). Determining the phases of tissue reaction after cementation and its radiographic revelation
will ease the diagnosis of residual lesions and subsequent recurrences after local resection and cementation of local aggressive
tumors. 相似文献
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Kurul SH Demirpence S Kiray M Tugyan K Yilmaz O Kose G 《The journal of headache and pain》2008,9(5):317-323
The aim was to investigate the immunoreactivities for NOS enzymes in frontal cortex and meningeal vessels after chemical stimulation of the subarachnoid space of adolescent rats and the effect of sumatriptan pre-treatment on the immunoreactivities of the NOS enzymes. Male adolescent Wistar rats were used. Rats in group 1 did not taken intracisternal injection. Rats in group 2 were taken intracisternal autologous blood injection, but no sumatriptan pre-treatment. Rats in group 3 were taken intracisternal autologous blood injection, but they were taken sumatriptan pre-treatment. Tissue samples were investigated for the presence of NOS immunoreactivity. The mean values of immunolabeling intensities for NOS enzymes in frontal cortex and meningeal vessels were significantly increased in group 2 compared to group 1. The mean values of immunolabeling intensities for NOS enzymes in frontal cortex and meningeal vessels were significantly reduced in group 3 compared to group 2. These results suggest that, chemical stimulation of the subarachnoid space increased the immunoreactivities of NOS enzymes in the brain of adolescent rats. The increased NOS immunoreactivities could be antagonized by pre-treatment with sumatriptan. 相似文献
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Semra Hiz Kurul Sumer Sutcuoglu Uluc Yis Nuray Duman Abdullah Kumral Hasan Özkan 《The journal of maternal-fetal & neonatal medicine》2013,26(7):584-588
Objective.?To evaluate the influence of ‘only electroencephalographic (EEG)’ and ‘EEG plus clinical’ seizures during neonatal period on neurodevelopment of the infants.Patients and methods.?The long-term digital-video- EEG tracings of the first 3 days of life of 30 neonates were assessed. The babies were subdivided into three groups: Group 1 had neither EEG nor clinical seizures. Group 2 had EEG seizures but no clinical seizures. Group 3 experienced both EEG and clinical seizures. The groups were compared in regard to psychomotor retardation and epilepsy at corrected age of 1 year.Results.?The mean birthweight was 1952.50 ± 978.74 (685–4103) g. The mean gestational age was 32.53 ± 4.26 (24–40) weeks. In regard to sex, gestational age and birth weight, there was no significant difference between the three groups. Ten percent of newborns in Group 1 and 53.8% of newborns in Group 3 had psychomotor retardation. No babies in Group 2 experienced psychomotor retardation. The differences between the Groups 1 and 3 and Groups 2 and 3 were found statistically significant. Only one baby in Group 3 had epilepsy. In Groups 1 and 2, no babies had epilepsy. The differences between the groups were not significant.Conclusion.?Neonatal seizures, but not silent EEG seizures are in relationship with poor neurodevelopmental outcome evaluated at corrected age of 1 year in newborns. 相似文献
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Erhan Bayram Yasemin Topcu Pakize Karakaya Meral Torun Bayram Ebru Sahin Nihan Gunduz Uluc Yis Ozlen Peker Semra Hiz Kurul 《Acta neurologica Belgica》2013,113(2):133-137
The aim of this study is to investigate the relationship between body composition, anthropometry, and motor scales in patients with Duchenne muscular dystrophy (DMD). Twenty six patients with DMD were evaluated by Expanded Hammersmith Functional Motor Scale (HFMSE), gross motor function classification system (GMFCS), multifrequency bioelectrical impedance analysis, and anthropometric measurements. Seventeen healthy children served as control group. There were 26 patients with a mean age of 9.5 ± 4.8 years. Ages and anthropometric measurements did not differ between groups. Of the 26 patients, nine were level I, seven were level II, two were level III, seven were level IV, and one was level V, according to the GMFCS. Despite the similar percentage of total body water, extracellular water/intracellular water ratio was significantly elevated in DMD patients (p = 0.001). Increased values of fat percentage and body fat mass index (BFMI) correlated positively with elevated GMFCS levels (r = 0.785 and 0.719 respectively). Increased fat-free mass index (FFMI) correlated negatively with elevated GMFCS levels (r = ?0.401). Increased fat percentage and BFMI correlated negatively with HFMSE scores (r = ?0.779 and ?0.698, respectively). Increased values of FFMI correlated positively with HFMSE scores. There was also a negative correlation between increased skin fold measurements from triceps and scapula and HFMSE scores (r = ?0.618 and ?0.683, respectively). Increased skin fold values from the same regions correlated positively with elevated GMFCS levels (r = 0.643 and 0.712, respectively). Significant body composition changes occur in patients with DMD. Anthropometric and multifrequency bioelectrical impedance analyses measurements show good correlation between motor function scales. These results may also be helpful to evaluate the effects of new treatment strategies. 相似文献
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The role of preoperative radiotherapy in nonmetastatic high-grade osteosarcoma of the extremities for limb-sparing surgery 总被引:1,自引:0,他引:1
Dinçbaş FO Koca S Mandel NM Hiz M Dervişoğlu S Seçmezacar H Oksüz DC Ceylaner B Uzel B 《International journal of radiation oncology, biology, physics》2005,62(3):820-828
PURPOSE: To assess the role of preoperative radiotherapy in patients with nonmetastatic high-grade osteosarcoma of the extremities for limb-sparing surgery and to compare the response of neoadjuvant therapies, local control, and survival with the literature results. METHODS AND MATERIALS: Forty-six patients with osteosarcoma of the limbs who were treated within a limb salvage protocol including preoperative radiotherapy and chemotherapy between 1987 and 2002, were retrospectively analyzed. Median age was 17 years (range, 14-66 years). Treatment was started with neoadjuvant chemotherapy. Cisplatin, epidoxorubicin, ifosfamide, and methotrexate were used in different combinations. Preoperative radiotherapy was applied, usually between the second and third cycle of chemotherapy. Radiotherapy was given (35 Gy in 10 fractions) to 44 patients. Two patients were treated with 46 Gy at 2 Gy/day. Definitive surgery was administered after the third course of chemotherapy. Chemotherapy was complete 6 courses postsurgery. RESULTS: Median follow-up time was 44 months (range, 2-154 months). Forty-four patients had limb-sparing surgery, whereas 2 had amputation. Tumor necrosis rate was >/=90% in 87% of the patients (Huvos Grade 3-4). Two patients had local failures, and 26 patients (56.5%) had distant metastases. The 5-year local control and overall survival rates were 97.5% and 48.4%, respectively. On univariate analysis, age =18 years, Huvos Grade 4, lower-extremity localization, and surgery within 1 month significantly survived better than the others. On multivariate analysis, Huvos grade (p = 0.01), age (p = 0.01), interval between neoadjuvant chemotherapy and surgery (p = 0.02), and extremity localization (p = 0.02) were significant prognostic factors for actuarial survival. Severe complication developed in 20% of the patients. CONCLUSION: Preoperative radiotherapy helps to increase the chance of extremity-sparing surgery with good local control and necrosis rate when combined with chemotherapy. 相似文献
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