全文获取类型
收费全文 | 10575篇 |
免费 | 571篇 |
国内免费 | 101篇 |
专业分类
耳鼻咽喉 | 94篇 |
儿科学 | 219篇 |
妇产科学 | 72篇 |
基础医学 | 1251篇 |
口腔科学 | 201篇 |
临床医学 | 776篇 |
内科学 | 2999篇 |
皮肤病学 | 99篇 |
神经病学 | 655篇 |
特种医学 | 542篇 |
外科学 | 1982篇 |
综合类 | 51篇 |
预防医学 | 256篇 |
眼科学 | 115篇 |
药学 | 491篇 |
中国医学 | 20篇 |
肿瘤学 | 1424篇 |
出版年
2024年 | 11篇 |
2023年 | 157篇 |
2022年 | 287篇 |
2021年 | 460篇 |
2020年 | 228篇 |
2019年 | 288篇 |
2018年 | 383篇 |
2017年 | 262篇 |
2016年 | 282篇 |
2015年 | 256篇 |
2014年 | 371篇 |
2013年 | 407篇 |
2012年 | 732篇 |
2011年 | 743篇 |
2010年 | 433篇 |
2009年 | 354篇 |
2008年 | 618篇 |
2007年 | 607篇 |
2006年 | 585篇 |
2005年 | 566篇 |
2004年 | 531篇 |
2003年 | 524篇 |
2002年 | 453篇 |
2001年 | 166篇 |
2000年 | 148篇 |
1999年 | 153篇 |
1998年 | 132篇 |
1997年 | 107篇 |
1996年 | 100篇 |
1995年 | 74篇 |
1994年 | 59篇 |
1993年 | 50篇 |
1992年 | 84篇 |
1991年 | 86篇 |
1990年 | 60篇 |
1989年 | 66篇 |
1988年 | 61篇 |
1987年 | 54篇 |
1986年 | 49篇 |
1985年 | 41篇 |
1984年 | 36篇 |
1983年 | 28篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1979年 | 20篇 |
1978年 | 15篇 |
1973年 | 15篇 |
1970年 | 9篇 |
1967年 | 9篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Takaharu Negoro Kanami Orihara Tomoko Irahara Hiroshi Nishiyama Kanae Hagiwara Risa Nishida Hiroki Takagi Kazue Satoh Yoshiki Yamamoto Shunichi Shimizu Tamio Hagiwara Masakazu Ishii Toshihiro Tanioka Yasuko Nakano Ken Takeda Isao Yoshimura Yoji Iikura Takashi Tobe 《Pediatric allergy and immunology》2006,17(8):583-590
Although many single nucleotide polymorphism (SNP) studies have reported an association of atopy, allergic diseases and total serum immunoglobulin E (IgE) levels, almost all of these studies sought risk factors for the onset of these allergic diseases. Furthermore, many studies have analyzed a single gene and hardly any have analyzed environmental factors. In these analyses, the results could be masked and the effects of other genes and environmental factors may be decreased. Here, we described the correlation between four genes [interleukin (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in connection with IgE production; the role of IL-10 (C-627A) as a regulatory cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) in 220 Japanese allergic children. In addition to these SNPs, environmental factors, i.e., patient's attitude, indoor environment, and so on, were also investigated in this study. Our study was retrospective, and the correlation was analyzed by our defined clinical scores divided into three terms: worst symptoms, recent symptoms and general amelioration at the most recent examination during the disease course. Our results indicated that IL-10 AA, the genotype with lower IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, estimate; 0.912). Marginal liver abnormalities were observed in the subject group with both FA and AE (p < 0.1191, estimate; 0.1490). Our defined clinical scores enabled evaluation of various aspects of disease severity. Based on the scores, while no single SNP selected in this study determined severity, the combination of the SNP with laboratory data and environmental factors appeared to determine severity. 相似文献
2.
Kazunori Aizawa Takeshi Hanaoka Hiroki Kasai Kaoru Kogashi Setsuo Kumazaki Jun Koyama Hiroshi Tsutsui Yoshikazu Yazaki Noboru Watanabe Osamu Kinoshita Uichi Ikeda 《Hypertension research》2006,29(2):123-128
The phosphodiesterase-5 (PDE-5) inhibitor, sildenafil, has been reported to produce sustained pulmonary vasodilatation in patients with pulmonary hypertension (PH). Recently, vardenafil, a more potent and selective PDE-5 inhibitor than sildenafil, has been approved for the treatment of erectile dysfunction. However, the long-term effects of oral vardenafil in patients with PH are unknown. We studied five consecutive patients with PH; one with primary pulmonary hypertension, two with chronic pulmonary thromboembolism, one with Eisenmenger syndrome (ventricular septal defect) and one with secondary pulmonary hypertension after a ventricular septal defect closure operation. In an acute hemodynamic trial, vardenafil (5 mg) significantly decreased both the pulmonary vascular resistance (PVR) and systemic vascular resistance (SVR) with an increase in cardiac output. In a chronic hemodynamic trial, the maintenance dose of vardenafil (10 to 15 mg) for 3 months significantly decreased the PVR, but not the SVR, with a 20.7% reduction of the PVR/ SVR ratio. Plasma brain natriuretic peptide (BNP) levels were also significantly decreased after 3 months. This pilot study demonstrates that long-term oral vardenafil therapy may be a safe and effective treatment for patients with PH. 相似文献
3.
Akira Sawaki Nobumasa Mizuno Kuniyuki Takahashi Tsuneya Nakamura Masahiro Tajika Hiroki Kawai Toshifumi Isaka Hiroshi Imaoka Yasuyuki Okamoto Masatoshi Aoki Hiroyuki Inoue Ahmed AS Salem Yasushi Yatabe Kenji Yamao 《Digestive endoscopy》2006,18(1):40-44
Background: Gastrointestinal stromal tumors (GIST) are one of the most common mesenchymal tumors of the gastrointestinal tract. GIST are defined by positive immunohistochemical staining for KIT or CD34 and thus are generally diagnosed after surgery. Because small GIST are rarely diagnosed before surgery, the clinical course of these small tumors is not clear. The aim of the present study was to follow changes in size and configuration of small GIST that were pathologically confirmed using endoscopic ultrasonography‐guided fine‐needle aspiration biopsy (EUS‐FNAB). Methods: Between July 1997 and December 2003, 16 tumors in 16 patients (10 men and 6 women) with an immunohistochemical diagnosis of GIST were regularly followed in our hospital. The median patient age when EUS‐FNAB was performed was 62 years (range 26–82 years) and the median follow‐up period was 4.9 years (range 0.5–9.6 years). Results: Fourteen tumors showed no remarkable changes in size and shape during follow up compared with the initial diagnosis. Two tumors enlarged: one tumor approximately doubled its diameter in 8 years and the other tumor increased from 1.8 cm at diagnosis to up to 10 cm after only 2 years. Doubling time of the latter tumor was calculated as 3.1 months. Conclusions: We conclude that EUS‐FNAB might be a good modality for final diagnosis of GIST without surgery, and that GIST without rapid growth on follow up can be endoscopically followed. 相似文献
4.
5.
Acute tendon rupture of the extensor pollicis longus (EPL) is rare. We present acute EPL tendon rupture associated with avulsed fracture of the second metacarpal at the insertion of extensor carpi radialis longus. Tendon rupture of the EPL was repaired with end-to-end suture and avulsed fracture of the second metacarpal base was treated with open reduction and internal fixation. 相似文献
6.
7.
8.
R Shiroki M Izumitani Y Tsukiashi S Saito K Ishiguro Y Fujioka I Nagakubo 《Hinyokika kiyo. Acta urologica Japonica》1990,36(11):1385-1388
Vasopressin, a hormone secreted from the posterior lobe of the hypophysis, has endocrinological and antidiuretic effects; it contracts vessels and smooth muscles, especially intestinal smooth muscle. In the present study, we investigated the role of vasopressin (Pitressin: arginine-vasopressin) in elimination of intestinal gas on excretory urography reading. Sixty outpatients were randomly divided into six groups. In Group I, the routine procedure was employed, i.e. laxatives the previous night and NPO the morning of the examination. In Groups II to VI, different dose regimens were employed: 6 or 10 units of Pitressin was administered by subcutaneous injection 30 minutes prior to injection of a contrast medium, with or without NPO. Intestinal gas elimination was evaluated by X-ray films taken before and after injection of Pitressin. The efficacy was rated by four grades. There were no significant differences in the gas elimination or occurrence of side effects between any two groups. Younger patients seemed to respond quickly to Pitressin and good effects were obtained. These results indicate that the pretreatment for excretory urography with 6 units of Pitressin without NPO may be a safe and effective alternative method for elimination of intestinal gas, in particular for young patients. 相似文献
9.
Pathogenesis of neuroimmunologic diseases 总被引:5,自引:0,他引:5
C. S. Constantinescu B. Milliard T. Fujioka M. K. Bhopale D. Calida Dr. A. M. Rostami 《Immunologic research》1998,17(1-2):217-227
Animal models of autoimmune diseases have greatly improved our current understanding of the pathogenesis of human autoimmunity
and have provided the potential for therapies based on manipulation of the immune system. In our laboratory, we have investigated
the immunopathogenesis of autoimmune diseases of the nervous system and muscle. We have developed immune-based approaches
for the suppression of experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), and experimental
autoimmune neuritis (EAN), a model for the Guillain-Barré syndrome (GBS). These approaches included induction of peripheral
tolerance, immunotoxin targeting of activated T cells, and cytokine manipulations. In addition, we identified the antigen
and characterized immunopathologically an autoimmune inflammatory disease of skeletal muscle, experimental autoimmune myositis
(EAM), a model for the human inflammatory muscle disease polymyositis. 相似文献
10.
M Nakamura E Koh N Kondoh M Takeyama M Namiki H Fujioka H Kiyohara Y Nishimune A Okuyama T Sonoda 《Archives of andrology》1990,24(1):69-72
The synthesis of DNA, RNA, and protein by varicocele testes with spermatogenic dysfunction was studied by examination of the levels of incorporation of [3H]thymidine, [14C]uridine, and [14C]leucine into the testicular tissue at 31 degrees C in vitro. The results suggest that DNA synthesis by the testis with moderate tubular damage is impaired whereas synthesis of RNA and protein is not. The cell regenerative ability of the testis with moderate tubular damage may be poor in spite of the preservation of testicular cell RNA and protein synthesis. 相似文献