全文获取类型
收费全文 | 201560篇 |
免费 | 2215篇 |
国内免费 | 159篇 |
专业分类
耳鼻咽喉 | 1398篇 |
儿科学 | 7070篇 |
妇产科学 | 3314篇 |
基础医学 | 19865篇 |
口腔科学 | 2049篇 |
临床医学 | 14049篇 |
内科学 | 37945篇 |
皮肤病学 | 1116篇 |
神经病学 | 18494篇 |
特种医学 | 9801篇 |
外科学 | 33327篇 |
综合类 | 2454篇 |
一般理论 | 2篇 |
预防医学 | 18708篇 |
眼科学 | 3163篇 |
药学 | 11239篇 |
中国医学 | 732篇 |
肿瘤学 | 19208篇 |
出版年
2023年 | 181篇 |
2022年 | 340篇 |
2021年 | 547篇 |
2020年 | 253篇 |
2019年 | 424篇 |
2018年 | 22309篇 |
2017年 | 17691篇 |
2016年 | 19894篇 |
2015年 | 1429篇 |
2014年 | 1490篇 |
2013年 | 1573篇 |
2012年 | 8349篇 |
2011年 | 22406篇 |
2010年 | 19556篇 |
2009年 | 12136篇 |
2008年 | 20652篇 |
2007年 | 22939篇 |
2006年 | 1902篇 |
2005年 | 3545篇 |
2004年 | 4676篇 |
2003年 | 5575篇 |
2002年 | 3761篇 |
2001年 | 1042篇 |
2000年 | 1199篇 |
1999年 | 935篇 |
1998年 | 554篇 |
1997年 | 482篇 |
1996年 | 383篇 |
1995年 | 335篇 |
1994年 | 331篇 |
1993年 | 262篇 |
1992年 | 581篇 |
1991年 | 634篇 |
1990年 | 632篇 |
1989年 | 559篇 |
1988年 | 434篇 |
1987年 | 387篇 |
1986年 | 399篇 |
1985年 | 367篇 |
1984年 | 255篇 |
1983年 | 219篇 |
1982年 | 136篇 |
1980年 | 150篇 |
1979年 | 186篇 |
1978年 | 133篇 |
1977年 | 120篇 |
1974年 | 121篇 |
1970年 | 111篇 |
1969年 | 118篇 |
1968年 | 117篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Hideyuki Masuda Makoto Kimura Akiko Nishioka Hiroshi Kato Akimichi Morita 《Journal of dermatological science》2019,93(2):109-115
Background
Photosensitizers used for photodynamic therapy (PDT) to treat dermatologic disease are metabolized into mainly protoporphyrin IX (PpIX), which has five absorption wavelength peaks: 410?nm, 510?nm, 545?nm, 580?nm, and 630?nm. Although only red light around 635?nm and blue light around 400?nm are used as light sources for PDT, the efficiency of PDT might be improved by using multiple wavelengths, including those that correspond to the other absorption peaks of PpIX. Furthermore, because the target disease often occurs on the face, a flexible-type light-source unit that can be fitted to the lesion without unnecessarily exposing the mucous membranes, e.g., the eyes, nostrils, and mouth, is preferred.Objective
We investigated the efficacy of a flexible light-emitting diode (LED) unit that emits multiple wavelengths to improve PDT effects.Methods
HaCaT cells were incubated with 5-ALA and subsequently irradiated with either a single wavelength or sequentially with two wavelengths. Cell viability and reactive oxygen species were analyzed. Nude mice were implanted with COLO679 cells by subcutaneous injection into the flank. 5-ALA was subcutaneously injected into the tumor. The tumor was irradiated with 50?J/cm2 (day 0) and assessed daily until day 21.Results
The synergistic PDT effects of dual-wavelength irradiation and reactive oxygen species production were highest with the 405-nm and 505-nm wavelength combination. This dual wavelength combination was also the most effective in vivo.Conclusion
We could therefore conclude that dual-wavelength PDT is an efficient strategy for improving the therapeutic effects of PDT. Using a flexible LED unit is expected to achieve more uniform irradiation of uneven areas. 相似文献2.
Hideki Kawaguchi Kazuko Masuo Tomohiro Katsuya Ken Sugimoto Hiromi Rakugi Toshio Ogihara Michael L Tuck 《Hypertension research》2006,29(12):951-959
High blood pressure (BP) is a major determinant of cardiovascular events in obesity. The beta2- and beta3-adrenoceptor polymorphisms are associated with obesity and hypertension. In the present study, we examine the relationships of beta2- and beta3-adrenoceptor polymorphisms with further weight gain-induced BP elevation in obese subjects. Changes in BP, body weight, total body fat-mass, waist-to-hip ratio, plasma norepinephrine (NE) and leptin levels, and beta2(Arg16Gly)- and beta3(Trp64Arg)-adrenoceptor polymorphisms were measured periodically over a 5-year period in 55 entry obese (body mass index [BMI]> or =25.0 kg/m(2)) normotensive (BP<140/90 mmHg) men. BP elevation and weight gain were defined as > or =10% increases from entry levels over 5 years in mean BP or BMI. Obese subjects with weight gain, BP elevation or weight gain-induced BP elevation had higher frequencies of the Gly16 allele of Arg16GIy and Arg64 allele of Trp64Arg. Subjects carrying the Gly16 or Arg64 alleles had significantly greater total fat-mass and waist-to-hip ratio at entry and over a 5-year period compared to the subjects who did not carry these polymorphisms. Subjects carrying the Gly16 allele had similar levels of plasma NE, higher levels of plasma leptin and a lower slope of the regression lines between plasma leptin and NE levels. Those carrying the Arg64 allele had higher plasma NE levels at entry and over a 5-year period compared to the subjects without the Arg64 allele, but plasma leptin levels and slopes were similar. The findings demonstrate that the Arg64 allele of the beta3-adrenoceptor polymorphisms relates to weight gain-induced BP elevation accompanying high plasma NE (heightened sympathetic activity) in obese men. The Gly16 allele of the beta2-adrenoceptor polymorphisms links to weight gain-induced BP elevation associated with leptin resistance. beta2- and beta3-adrenoceptor polymorphisms could predict the future BP elevation and further weight gain-induced BP elevation in originally obese subjects. 相似文献
3.
4.
5.
6.
7.
Susanne Ramsauer 《Zeitschrift für Psychodrama und Soziometrie》2007,6(2):293-302
Anliegen dieses Artikels ist, die besondere Qualit?t und Chance von Psychodramatischer Supervision zu beschreiben, und gleichzeitig
die Kompatibilit?t und fruchtbare Erg?nzung des Moreno’schen Ansatzes innerhalb des Formats Supervision innerhalb der Sozialen
Arbeit auf zuzeigen. Dies wird anhand von 2 ausgew?hlten Praxisbeispielen dargestellt. Die Handlungskompetenz von Supervisandinnen
und Supervisanden kann durch einfache psychodramatische Interventionen erweitert werden. Handlungshemmung wird überwunden,
Spontaneit?t und Kreativit?t kommen ins Laufen und er?ffnen Perspektiven. 相似文献
8.
9.
Debra L. Roter Richard M. Frankel Judith A. Hall David Sluyter 《Journal of general internal medicine》2006,21(1):28-34
Relationship-centered care reflects both knowing and feeling: the knowledge that physician and patient bring from their respective domains of expertise, and the physician’s and patient’s experience, expression, and perception of emotions during the medical encounter. These processes are conveyed and reciprocated in the care process through verbal and nonverbal communication. We suggest that the emotional context of care is especially related to nonverbal communication and that emotion-related communication skills, including sending and receiving nonverbal messages and emotional self-awareness, are critical elements of high-quality care. Although nonverbal behavior has received far less study than other care processes, the current review argues that it holds significance for the therapeutic relationship and influences important outcomes including satisfaction, adherence, and clinical outcomes of care. 相似文献
10.