全文获取类型
收费全文 | 5326篇 |
免费 | 319篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 67篇 |
儿科学 | 130篇 |
妇产科学 | 58篇 |
基础医学 | 856篇 |
口腔科学 | 140篇 |
临床医学 | 503篇 |
内科学 | 1145篇 |
皮肤病学 | 161篇 |
神经病学 | 542篇 |
特种医学 | 248篇 |
外科学 | 758篇 |
综合类 | 22篇 |
一般理论 | 2篇 |
预防医学 | 281篇 |
眼科学 | 48篇 |
药学 | 394篇 |
中国医学 | 3篇 |
肿瘤学 | 319篇 |
出版年
2023年 | 22篇 |
2022年 | 45篇 |
2021年 | 97篇 |
2020年 | 74篇 |
2019年 | 96篇 |
2018年 | 151篇 |
2017年 | 110篇 |
2016年 | 142篇 |
2015年 | 114篇 |
2014年 | 157篇 |
2013年 | 234篇 |
2012年 | 308篇 |
2011年 | 327篇 |
2010年 | 222篇 |
2009年 | 209篇 |
2008年 | 324篇 |
2007年 | 335篇 |
2006年 | 294篇 |
2005年 | 275篇 |
2004年 | 258篇 |
2003年 | 262篇 |
2002年 | 228篇 |
2001年 | 73篇 |
2000年 | 80篇 |
1999年 | 72篇 |
1998年 | 53篇 |
1997年 | 45篇 |
1996年 | 31篇 |
1995年 | 26篇 |
1994年 | 35篇 |
1993年 | 22篇 |
1992年 | 41篇 |
1991年 | 47篇 |
1990年 | 42篇 |
1989年 | 45篇 |
1988年 | 34篇 |
1987年 | 35篇 |
1986年 | 35篇 |
1985年 | 36篇 |
1984年 | 45篇 |
1983年 | 33篇 |
1982年 | 25篇 |
1980年 | 23篇 |
1979年 | 26篇 |
1978年 | 37篇 |
1977年 | 31篇 |
1975年 | 22篇 |
1974年 | 22篇 |
1972年 | 22篇 |
1971年 | 24篇 |
排序方式: 共有5677条查询结果,搜索用时 15 毫秒
1.
Willemijn A K M Windt Atsua Tahara Alex C A Kluppel Dick de Zeeuw Robert H Henning Richard P E van Dokkum 《Journal of the renin-angiotensin-aldosterone system》2006,7(4):217-224
INTRODUCTION: Vasopressin, mainly through the V1a-receptor, is thought to be a major player in the maintenance of hyperfiltration. Its inhibition could therefore lead to a decrease in progression of chronic renal failure. To this end, the effect of the vasopressin V1a-receptor-selective antagonist, YM218, was studied on proteinuria and focal glomerulosclerosis in early and late intervention after 5/6 nephrectomy in rats, and compared with an angiotensin-converting enzyme inhibitor (ACE-I). MATERIALS AND METHODS: After 5/6 nephrectomy, early intervention was performed between week 2 and 10 thereafter with the V1a-receptor-selective antagonist (VRA, 10 mg/kg/day, n=10), enalapril (ACE-I, 10 mg/kg/day, n=9), or vehicle (n=8). Late intervention was performed in another group between week 6 and 12 with VRA (10 mg/kg/day, n=7), lisinopril (ACE-I, 5 mg/kg/day, n=7), or vehicle (n=7). RESULTS: In early intervention, proteinuria and focal glomerulosclerosis were significantly decreased by VRA compared to vehicle (44+7% and 59+8% respectively). ACE-I significantly decreased proteinuria (67+7%) and a trend towards a decrease in focal glomerulosclerosis was observed (30+18%). In late intervention, VRA did not decrease proteinuria and focal glomerulosclerosis compared to vehicle (21+20% and 0%, respectively), ACE-I significantly lowered proteinuria (92+2%) and a focal glomerulosclerosis (69+1%) lowering trend was observed. CONCLUSION: These results indicate that VRA may protect against early progression of renal injury after 5/6 nephrectomy, whereas its effectiveness seems limited in established renal damage. 相似文献
2.
3.
Previously we have shown that the dorsal lateral geniculate body (LGB), which is strictly visual in sighted mammals, receives a strong auditory input in the naturally blind mole rat (Spalax ehrenbergi). Here we show with the 2-deoxyglucose technique and with single-unit recordings that in this species the initially non-degenerated visual cortex, as defined by its connection with LGB, is also activated by the auditory modality. These findings suggest that cross-modal compensation may occur as a natural consequence of the degeneration of a sense organ. 相似文献
4.
5.
6.
Michael Brauckhoff Oliver Gimm Udo Bilkenroth Raoul Hinze Henning Dralle 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2002,387(5-6):201-203
BACKGROUND: In most examined populations the RET germline polymorphism S836S is found in about 3.6% of the normal population but in about 9% of patients suffering from sporadic C-cell hyperplasia or medullary thyroid carcinoma. The polymorphism S836S is thought to be involved in the development of sporadic medullary thyroid carcinoma. CASE PRESENTATION: We report a 48-year-old woman suffering from primary hyperparathyroidism (parathormone 121-166 pg/ml, normal <72), bilateral diffuse and nodular C-cell hyperplasia (calcitonin after pentagastrin administration 156 pg/ml, normal <4.6), and papillary thyroid carcinoma. Two commercial analyses of RET did not reveal any germline mutation within the known hot spots. However, sequencing revealed the presence of the RET polymorphism S836S. Following total thyroidectomy and removal of two hyperplastic parathyroid glands parathormone decreased to 51 pg/ml and calcitonin was no longer detected. CONCLUSIONS: The pathogenetic importance of the RET polymorphism S836S is still obscure. However, according to the published overrepresentation of the RET polymorphism S836S in patients suffering from apparent sporadic medullary thyroid carcinoma, it is conceivable that it also plays a role in multiglandular endocrine disease. 相似文献
7.
Report on a case of aneurysm in a child and its treatment with discussion of its rarity and origin. 相似文献
8.
Jochen P?ling Wolfgang Rees Vittorio Mantovani Stephan Klaus Ludger Bahlmann Virgilius Ziaukas Norbert Hübner Henning Warnecke 《European journal of cardio-thoracic surgery》2006,30(4):597-603
BACKGROUND: For the first time, microdialysis was used to investigate in vivo and online the myocardial metabolism during and after cardiac surgery in patients treated with two different methods of myocardial protection. METHODS: Thirty patients underwent standard CABG with one of two different methods of myocardial protection. The patients were randomised to receive either cold blood (COLD group) or warm modified Calafiore cardioplegia (WARM group). Microdialysis probes were implanted into the myocardium of left ventricular apical region of the heart. Cardioplegia was given antegrade only. Microdialysis measurements were performed at time intervals before, during and 24 h after cardiopulmonary bypass and analysed for glucose, lactate, pyruvate and glycerol. RESULTS: Myocardial lactate concentrations were significantly higher in the WARM group compared with that of the COLD group, while serum lactate was comparable. Glycerol was significantly higher at the end of the clamping time in the WARM group. At the same time the glucose-lactate ratio as a marker of nutritional disorder had significantly lower levels in the WARM group. The cumulative CK-MB release over 24 h was significantly higher in those hearts protected with warm blood. CONCLUSIONS: The oxidative stress measured was significantly higher in patients undergoing CABG using modified Calafiore cardioplegia, whereas the cold cardioplegia minimised the effects of aortic clamping. The results indicate that cold cardioplegia offers superior protection of the heart, in terms of more rapid normalisation of myocardial metabolism. In elective myocardial revascularisation, intermittent antegrade warm blood cardioplegia is a comparable safe method of myocardial protection. However, in patients referring to a long clamping time, advantages of cold cardioplegia for myocardial revascularisation may be magnified. 相似文献
9.
The existence of an ontogenetic shift of tonotopic organization throughout the auditory pathway concomitant with cochlea maturation is a matter of controversy. Using the 2-deoxyglucose method we demonstrate here for the first time the shift phenomenon in an auditory forebrain structure, field L, the auditory cortex analogue of the chick. During the first postnatal month isofrequency contours move to positions where, in younger chicks, lower frequencies (up to half an octave) are represented. This developmentally changing place code of sound frequencies at the forebrain level is similar to the one previously reported for brain stem auditory nuclei. It raises the question of constancy of frequency-related pitch perception during development and may be a complication of early auditory learning and memory. 相似文献
10.
Understanding the pathologic Haglund's deformity 总被引:1,自引:0,他引:1
Pathologic conditions behind the calcaneus are common, and may initiate during early childhood. The authors discuss osseous and soft tissue conditions involving the posterior-superior surface of the heel. Radiographic and clinical evaluation is considered. Treatment alternatives are also reviewed. 相似文献