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1.
Spleen cells of a Biozzi HR mouse immunized with a bovine serum albumin-methotrexate conjugate were fused with P3-X63-Ag8.653 mouse myeloma cells. Twenty-three monoclonal antibodies (MAbs), selected by indirect ELISA, were produced and partially characterized. Using methotrexate (MTX) and eight structurally related compounds, binding specificities of the MAbs were assessed by inhibition enzyme immunoassay. All the MAbs had very low affinity for folic acid and its analogs and for the major MTX metabolite 7-hydroxymethotrexate. Using a computer cluster analysis program based on the binding specificities, the MAbs were divided into three groups. The thirteen MAbs in group I recognized primarily the pteridine portion of the MTX molecule; the eight group II MAbs recognized the benzene ring as well as the pteridine structure. The two MAbs in group III poorly distinguished between the different parts of the MTX molecule. The apparent equilibrium association constants of the anti-MTX MAbs in groups I, II, and III ranged from 7 x 10(9) to 3 x 10(8) M-1 (except for 1 MAb), from 5 x 10(7) to 6 x 10(6) M-1 (except for 2 MAbs), and from 1 x 10(6) to 3.5 x 10(5) M-1, respectively. 相似文献
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Introduction and objective
Gestational weight gain (GWG) has been reported to be associated with pregnancy outcomes. The aim of this study was to evaluate the effects of GWG on maternal and birth complications.Materials and methods
A prospective and longitudinal cohort study was conducted among pregnant women who had attended antenatal centers in Constantine, Algeria, between 2013 and 2015. Two hundred pregnant women aged 19 to 41 years old were followed for 9 months of pregnancy. They underwent body weight measurement during routine examination at first, second and third trimester. GWG was categorized as below, within or above the Institute of Medicine (IOM) (2009) recommendations. Data included age and parity. Pregnancy outcomes were analyzed in relation to GWG.Results
Mean GWG was 8.9 ± 5.4 kg. Among all subjects, only 27.5% of women had gained the recommended amount of weight, with 48.5% gaining less than recommended, and 24.0% gaining more than recommended by the IOM. High birth weight was significantly more frequent in women with excessive weight gain, compared to those with normal gain (27.1% vs 14.5%, P = 0.04). The percentage of low birth infants was statistically very high in pregnant women with excessive weight gain, compared to women with normal gain (14.6% vs 3.6%, P = 0.04). The risk of gestational hypertension increased with excessive GWG (P < 0.01).Conclusion
The pregnancy and birth outcomes depend on the women's gestational weight gain. 相似文献7.
Jennifer K. Logan Soroush Rais‐Bahrami Baris Turkbey Andrew Gomella Hayet Amalou Peter L. Choyke Bradford J. Wood Peter A. Pinto 《BJU international》2014,114(5):641-652
Prostate MRI is currently the best diagnostic imaging method for detecting PCa. Magnetic resonance imaging (MRI)/ultrasonography (US) fusion allows the sensitivity and specificity of MRI to be combined with the real‐time capabilities of transrectal ultrasonography (TRUS). Multiple approaches and techniques exist for MRI/US fusion and include direct ‘in bore’ MRI biopsies, cognitive fusion, and MRI/US fusion via software‐based image coregistration platforms. 相似文献
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Alain Créange Nortina Shahrizaila Hayet Salhi Jean‐Pascal Lefaucheur Nobuhiro Yuki 《Journal of the peripheral nervous system : JPNS》2014,19(2):115-120
A close relationship between acute motor conduction block neuropathy and antibodies against the complex of GM1 and GalNAc‐GD1a has been reported. This study investigates the hypothesis that conduction block at the early phase of axonal Guillain‐Barré syndrome (GBS) is also associated with such ganglioside complexes. Sera were obtained from seven French patients with initial evidence of isolated conduction blocks that resolved or progressed to acute motor axonal neuropathy. Serum IgG to asialo‐GM1 and gangliosides of LM1, GM1, GM1b, GD1a, GalNAc‐GD1a, GD1b, GT1a, GT1b, and GQ1b as well as their complexes were measured. Five of seven patients progressed within the first month of disease to AMAN. One patient had IgG antibodies against the complex of asialo‐GM1 and each of the other ganglioside antigens. Another patient carried IgG antibodies against GM1 complex with GM1b, GD1a, and GT1a as well as asialo‐GM1 complex with GD1a and GT1a. None had IgG antibodies against GM1/GalNAc‐GD1a complex. Six patients had IgG against single antigens GM1, GD1a, GalNAc‐GD1a, GD1b, and asialo‐GM1. In three patients, a reduced reaction against GM1/GalNAc‐GD1a complex was observed. The presence of conduction block in axonal GBS is not always associated with anti‐GM1/GalNAc‐GD1a complex antibodies. 相似文献