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排序方式： 共有75条查询结果，搜索用时 62 毫秒
1.
Arbelo Nestor López-Pelayo Hugo Sagué María Madero Santiago Pinzón-Espinosa Justo Gomes-da-Costa Susana Ilzarbe Lidia Anmella Gerard Llach Cristian-Daniel Imaz María-Luisa Cámara María-Mercé Pintor Luis 《The Psychiatric quarterly》2021,92(3):1021-1033
Psychiatric Quarterly - The Coronavirus Disease 2019 (COVID-19) can affect mental health in different ways. There is little research about psychiatric complications in hospitalized patients with... 相似文献
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We present the case of a 4-year-old boy with malaria who developed acute respiratory distress syndrome with severe hypoxemia refractory to mechanical ventilation and inhaled nitric oxide. Placing the patient in prone position immediately and persistently improved oxygenation: the ratio of P(aO(2)) to fraction of inspired oxygen rose from 47 to 180 mm Hg and the oxygenation index decreased from 40 to 11. The patient survived, with no respiratory sequelae. 相似文献
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Josep M. Llibre Elisa de Lazzari Jean-Michel Molina Sébastien Gallien Juan Gonzalez-García Arkaitz Imaz Daniel Podzamczer Bonaventura Clotet Pere Domingo Josep M. Gatell 《Enfermedades infecciosas y microbiología clínica》2018,36(1):16-20
Objective
To evaluate the efficiency of single-tablet regimens (STR) and multiple-tablet regimens (MTR) with exactly the same or different components.Methods
A study was conducted on HIV-1-infected antiretroviral-naïve patients from 6 Spanish or French centers, who were started on treatment with STR-Atripla®, or the same components separately (MTR-SC), or a different MTR (MTR-Other). Effectiveness was measured as percentage of HIV-RNA <50 copies/mL at 48 weeks (ITT). Efficiency was the ratio between costs (direct cost of antiretrovirals plus outpatient visits, hospital admissions, and resistance tests) and effectiveness.Results
The study included a total of 2773 patients (759 STR-Atripla®, 483 MTR-SC, and 1531 MTR-Other). Median age was 37 years, 15% were HCV co-infected, 27% had a CD4+ count <200 cells/μL, and 30% had viral load ≥100.000 copies/mL. The duration of the assigned treatment was longer for STR-Atripla® (P < .0001). Response rates (adjusted for CD4+ count, viral load, and clustered on hospitals) at 48 weeks were 76%, 74%, and 62%, respectively (P < .0001). Virological failure was more common in MTR patients (P = .0025), and interruptions due to intolerance with MTR-Other (P < .0001). Cost per responder at 48 weeks (efficiency) was €12,406 with STR-Atripla®, €11,034 with MTR-SC (0.89 [0.82, 0.99] times lower), and €18,353 (1.48 [1.38, 1.61] times higher) with MTR-Other.Conclusions
STR-Atripla® and MTR-SC regimens showed similar effectiveness, but virological failure rate was lower with STR-Atripla. MTR-SC, considered less convenient, had a marginally better efficiency, mainly due to lower direct costs. MTR-Other regimens had both a worse effectiveness and efficiency. Similar efficiency analyses adjusting for baseline characteristics should be recommended for new STRs. 相似文献9.