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Deterioration of dyslexia after non‐dominant temporal lobectomy for drug‐resistant epilepsy
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Roel H.L. Haeren Marc P.H. Hendriks Marielle Vlooswijk Lex Verdyck Vivianne H.J.M. van Kranen‐Mastenbroek Louis Wagner Sophie van Benthum Olaf E.M.G. Schijns 《Epileptic Disord》2016,18(1):77-82
We present a patient with drug‐resistant right‐sided temporal lobe epilepsy, caused by a ganglioglioma of the parahippocampal gyrus. Preoperatively, the patient was also known to have dyslexia. A right‐sided anterior temporal lobectomy, including complete lesionectomy, was performed. Several months after the otherwise uncomplicated procedure, the patient complained about visual memory disturbances, accompanied by increased reading and spelling problems. Postoperative neuropsychological examination revealed deterioration of the visual memory functions, compared to the preoperative assessment, and consequently provided a possible explanation for worsening of the pre‐existing dyslexia. In this case report, we hypothesize on the cause of this unusual deterioration and present recommendations to be included in the preoperative epilepsy surgery evaluation for patients with verbal or reading disorders such as dyslexia. 相似文献
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Nobels-Janssen E. Postma E. N. Abma I. L. van Dijk J. M. C. Haeren R. Schenck H. Moojen W. A. den Hertog M. H. Nanda D. Potgieser A. R. E. Coert B. A. Verhagen W. I. M. Bartels R. H. M. A. van der Wees P. J. Verbaan D. Boogaarts H. D. 《Journal of neurology》2022,269(5):2734-2742
Journal of Neurology - The modified Rankin Scale (mRS) is one of the most frequently used outcome measures in trials in patients with an aneurysmal subarachnoid hemorrhage (aSAH). The assessment... 相似文献
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Potential drug users participated voluntarily in a Belgian study on the usefulness of the non-instrumental immunoassay Drugwipe
(Securetec, Germany) for the screening of cocaine, opiates, amphetamine and cannabinoids in saliva and sweat. If one of the
screening assays (urine, oral fluid, sweat) showed a positive result, blood and saliva were collected. The on-site Drugwipe
results were correlated with the Drugwipe results for saliva in the laboratory and with the GC/MS results of the corresponding
saliva, plasma and urine samples and pharmacological effects at the time of sampling. The Drugwipe assay proved to be sufficiently
sensitive for the detection of recent cocaine (n = 6) and amphetamine (n = 15) abuse, whether the device was wiped on the tongue or on the surface of the body, or when a saliva sample was applied
to the wiping part. In five of the six potential cocaine users, the saliva concentrations of cocaine exceeded 1000 ng/ml.
In the amphetamine group, the saliva concentrations of amphetamine, MDMA or both were high (> 1000 ng/ml) in 13 subjects.
For cocaine and amphetamine, the positive scores for Drugwipe matched the GC/MS results for the three body fluids. Recent
heroin abuse (n = 5) could be demonstrated to some extent with Drugwipe on samples from the tongue but only the two subjects with the highest
saliva concentrations of MAM (> 500 ng/ml) and morphine (> 500 ng/ml) were positive. If the legal cut-off value for driving
under the influence of opiates in Belgium (20 ng/ml of free morphine in plasma) was taken into account, only three subjects
would have been legally positive. For cannabinoids (n = 15), false negatives and even some false positives were observed. Saliva can be considered as a useful analytical matrix
for the detection of drugs of abuse after recent abuse when analysed with GC/MS.
Received: 26 January 1999 / Received in revised form: 19 May 1999 / Accepted: 17 June 1999 相似文献
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Rick HGJ van Lanen Stan Melchers Govert Hoogland Olaf EMG Schijns Marc AMJ van Zandvoort Roel HL Haeren Kim Rijkers 《Journal of cerebral blood flow and metabolism》2021,41(10):2492
The blood-brain barrier (BBB) is dysfunctional in temporal lobe epilepsy (TLE). In this regard, microvascular changes are likely present. The aim of this review is to provide an overview of the current knowledge on microvascular changes in epilepsy, and includes clinical and preclinical evidence of seizure induced angiogenesis, barriergenesis and microcirculatory alterations. Anatomical studies show increased microvascular density in the hippocampus, amygdala, and neocortex accompanied by BBB leakage in various rodent epilepsy models. In human TLE, a decrease in afferent vessels, morphologically abnormal vessels, and an increase in endothelial basement membranes have been observed. Both clinical and experimental evidence suggests that basement membrane changes, such as string vessels and protrusions, indicate and visualize a misbalance between endothelial cell proliferation and barriergenesis. Vascular endothelial growth factor (VEGF) appears to play a crucial role. Following an altered vascular anatomy, its physiological functioning is affected as expressed by neurovascular decoupling that subsequently leads to hypoperfusion, disrupted parenchymal homeostasis and potentially to seizures”. Thus, epilepsy might be a condition characterized by disturbed cerebral microvasculature in which VEGF plays a pivotal role. Additional physiological data from patients is however required to validate findings from models and histological studies on patient biopsies. 相似文献
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