全文获取类型
收费全文 | 910篇 |
免费 | 15篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 15篇 |
妇产科学 | 10篇 |
基础医学 | 137篇 |
口腔科学 | 22篇 |
临床医学 | 31篇 |
内科学 | 145篇 |
皮肤病学 | 20篇 |
神经病学 | 135篇 |
特种医学 | 25篇 |
外科学 | 52篇 |
预防医学 | 175篇 |
眼科学 | 7篇 |
药学 | 109篇 |
中国医学 | 1篇 |
肿瘤学 | 52篇 |
出版年
2022年 | 3篇 |
2021年 | 5篇 |
2020年 | 4篇 |
2019年 | 8篇 |
2017年 | 8篇 |
2016年 | 7篇 |
2015年 | 6篇 |
2014年 | 23篇 |
2013年 | 24篇 |
2012年 | 51篇 |
2011年 | 50篇 |
2010年 | 22篇 |
2009年 | 28篇 |
2008年 | 51篇 |
2007年 | 57篇 |
2006年 | 61篇 |
2005年 | 60篇 |
2004年 | 63篇 |
2003年 | 38篇 |
2002年 | 68篇 |
2001年 | 14篇 |
2000年 | 20篇 |
1999年 | 18篇 |
1998年 | 8篇 |
1997年 | 9篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 22篇 |
1991年 | 10篇 |
1990年 | 8篇 |
1989年 | 3篇 |
1988年 | 13篇 |
1987年 | 12篇 |
1986年 | 7篇 |
1985年 | 16篇 |
1984年 | 19篇 |
1983年 | 12篇 |
1982年 | 12篇 |
1981年 | 13篇 |
1980年 | 5篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1973年 | 5篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1933年 | 2篇 |
排序方式: 共有940条查询结果,搜索用时 15 毫秒
1.
Subchronic administration of cocaine induces behavioral sensitization (increasing hypermotility) to a challenge dose of the drug administered 72 h after the cessation of treatment. The effects of repeated administration of the neurohypophyseal hormones oxytocin (OXT) and arginine8-vasopressin (AVP) on the development of behavioral sensitization induced by subchronic treatment with cocaine were investigated in mice. Repeated treatment of OXT and AVP did not modify the locomotor stimulatory effect of the challenge dose of cocaine in cocaine-naive control animals. OXT in a dose of 0.5 microgram (sc) augmented the cocaine-induced behavioral sensitization. In contrast, AVP (0.005-0.5 microgram/mouse, sc) dose dependently attenuated the development of sensitization to the hypermotility-inducing effect of cocaine. The results suggest that the behavioral sensitization induced by cocaine can be modulated in opposite directions by neurohypophyseal hormones. 相似文献
2.
István Pintér János Mátyus Zoltán Czégány Judit Harsányi Marietta Homoki Miklós Kassai Eva Kiss István Kiss Erzsébet Ladányi Lajos Locsey Lajos Major Mihály Misz Lajos Nagy Kálmán Polner Jeno Rédl István Solt Béla Tichy Marietta T?r?k Gábor Varga Gyula Wagner Imre Wórum Béla Zsoldos László Pótó Katalin Dérczy István Wittmann Judit Nagy 《Nephrology, dialysis, transplantation》2004,19(4):840-843
BACKGROUND: The diagnosis of analgesic nephropathy has improved significantly with modern imaging techniques. We reviewed a large portion of the Hungarian dialysis population to obtain additional insight into the problem. METHODS: Twenty-two participating dialysis units enrolled 1400 patients on renal replacement therapy between 1 January 1995 and 1 January 1998. Patients with no known aetiology (n = 284) were interviewed and studied with renal imaging. We assessed the presence of decreased renal mass combined with either bumpy contours, papillary calcification, or both. The subjects studied were interrogated extensively. RESULTS: Our survey suggested analgesic nephropathy in 47 of 1400 patients (3.3%), 3-fold higher than the EDTA database estimate for Hungary. The analgesics most commonly abused were phenacetin-containing mixtures. The driving symptoms were mainly headache and joint pain. Cardiovascular complications were more common than in the rest of the dialysis population, independent of smoking and lipid values (P<0.01). CONCLUSIONS: Phenacetin should be banned. Our study results support the need for longitudinal cohort and case-control studies in Hungary. 相似文献
3.
The effects of different doses of calcitonin gene-related peptide (CGRP) on passive avoidance behaviour were studied in male rats following its intracerebroventricular (i.c.v.) administration. Treatment with doses of 200 ng, 300 ng, 500 ng or 1 microgram was performed prior to learning, immediately and 6 h after the learning session and 30 min before the 24 h retention test. CGRP enhanced the avoidance latency in a dose-dependent manner at each time studied, with the exception of 6 h after the learning session. It is concluded that CGRP might be able to lengthen the passive avoidance latency by facilitating learning and memory formation. 相似文献
4.
5.
6.
A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity 总被引:8,自引:0,他引:8
Acsadi Gyula; Jani Agnes; Massie Bernard; Simoneau Maude; Holland Paul; Blaschuk Katharine; Karpati George 《Human molecular genetics》1994,3(4):579-584
High titre (10111012 pfu/ml) suspensions of autonomouslyreplication-defective type 5 human adenovirus (AV) recombinantswith different reporter gene inserts (CMV-Luciferase (Lux),CMV-ß-galactosidase (Lac Z), RSV-Lux and RSV-Lac Z)were injected Into intact quadrlceps muscles of 15 dayold (Group 1) or 3545 day old (Group 2) normal mice,as well as regenerating adult mouse muscles (Group 3) and 35day old mdx muscles (Group 4). The expression of the reportergenes was quantitated 10 days and 2 months later. At 10 dayspostinjection all reporter gene expression was very high inthe neonatally injected (Group 1) muscles. In Group 2 musclesthe transduction was markedly less. In Group 3 muscles the geneexpression was significantly better than in the Group 2 muscles.In adult mdx muscles (Group 4) where spontaneous regenerationis usually present, the results were similar to those in Group3 animals. At 2 months post-injection in Group 1 animals, theRSV-Lux expression was even higher than at 10 days postinjection.The cell surface density of 相似文献
7.
The occurrence of Chlamydia trachomatis in the semen of men participating in an IVF programme 总被引:1,自引:0,他引:1
Nagy Balint; Corradi Gyula; Vajda Zoltan; Gimes RezsO; Csomor Sandor 《Human reproduction (Oxford, England)》1989,4(1):54-56
Chlamydia trachomatis is one of the most common causative agentsof sexually transmitted diseases. The authors studied the occurrenceof C.trachomatis in the semen of 184 asymptomatic men participatingin the IVF programme. Twenty-six (14.1%) of the 184 tested werepositive for C.trachomatis, these patients and their wives receivingdoxycycline capsules twice, 100 mg on the first day and 100mg/day for the following 13 days. This treatment was effectivein 88.5% of the cases and in the rest, treatment continued witherithromycin 250 mg four times/day for 2 weeks. The authorscompared the semen parameters (cell count, motility, morphology,bovine mucus penetration and hypo-osmotic swelling test) inthe infected and non-infected groups and observed no significantdifference between these two groups 相似文献
8.
Alteration of the LRP1B gene region is associated with high grade of urothelial cancer 总被引:6,自引:0,他引:6
Langbein S Szakacs O Wilhelm M Sukosd F Weber S Jauch A Lopez Beltran A Alken P Kälble T Kovacs G 《Laboratory investigation; a journal of technical methods and pathology》2002,82(5):639-643
We have delineated regions of interest at chromosome 2q21.2, 2q36.3, and 2q37.1 by deletion mapping of 114 urothelial cancers (UC). Altogether, 17%, 18%, and 63% of the G1, G2, and G3 tumors displayed loss of heterozygosity at chromosome 2q, respectively, The region at 2q21.2 was narrowed down to the LRP1B gene (NT_005129.6). Hemi- and homozygous deletion at the LRP1B gene region was seen in 31 of 114 UCs. Only 8% of the UCs with G1 and none with G2 tumors showed loss of heterozygosity at the LRP1B gene, whereas 49% of the G3 UCs had allelic loss at this region. RT-PCR analysis of the LRP1B gene showed the lack of expression of several exons in 2 of 9 cases analyzed. Our analysis suggests that the LRP1B gene is a candidate tumor suppressor gene in UCs. 相似文献
9.
E. Knyihár-Csillik János Tajti Mohtasham Samsam Gyula Sáry Péter Buzás László Vécsei 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,118(1):111-114
Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from
ipsilateral central terminals of pseudounipolar primary sensory ganglion cells. Affected terminals exhibit decreased CGRP
immunoreactivity as shown by cytophotometric densitomery of the caudal trigeminal nucleus. The decrease in CGRP immunoreactivity
is statistically significant only in the medial one-third of the caudal trigeminal nucleus. Since earlier studies have shown
that electrical stimulation of the Gasserian ganglion induces first accumulation then depletion of CGRP from perivascular
sensory terminals in the dura mater, the present experiments suggest that CGRP is depleted also from central terminals of
primary sensory trigeminal neurons, which might be of importance in the pathogenesis of migraine headache.
Received: 18 December 1996 / Accepted: 26 June 1997 相似文献
10.
Horváth G Stotz G Tolvaj G Osztrogonácz H Dávid K 《Pathology oncology research : POR》1996,2(1-2):59-62
The results of 43 interferon treatments of 35 patients (23 male, 12 female) are reported. The duration of the treatment was
6–18 months, the dose of interferon was 3x3-5 MU weekly. Complete response (HCV RNA became negative) was found in 11, relapse
was observed in 3 patients. Partial response (transaminase levels became normal, or less than twice normal value, but patients
remained HCV RNA positive) occurred in 23 cases, relapse was obeserved in 16. The therapy had no effect in 9 cases. The higher
dose and longer term interferon therapy resulted in a higher rate of response to the treatment and a reduction in the number
of relapses.
This work was supported by the Hungarian Ministry of Welfare (No. T-10 064/93). 相似文献