排序方式: 共有10条查询结果,搜索用时 15 毫秒
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Jon Pérez-Bárcena Pedro Marsé Arturo Zabalegui-Pérez Esther Corral Rubén Herrán-Monge María Gero-Escapa Mercedes Cervera Juan Antonio Llompart-Pou Ignacio Ayestarán Joan Maria Raurich Antonio Oliver Antonio Buño Abelardo García de Lorenzo Guiem Frontera 《Intensive care medicine》2014,40(4):539-547
Purpose
To evaluate the effect of the intravenous (i.v.) l-alanyl-l-glutamine dipeptide supplementation during 5 days on clinical outcome in trauma patients admitted to the intensive care unit (ICU).Methods
This was a prospective, randomized, double-blind, multicenter trial. Glutamine was not given as a component of nutrition but as an extra infusion. The primary outcome variable was the number of new infections within the first 14 days.Results
We included 142 patients. There were no differences between groups in baseline characteristics. Up to 62 % of the patients in the placebo group and 63 % in the treatment group presented confirmed infections (p = 0.86). ICU length of stay was 14 days in both groups (p = 0.54). Hospital length of stay was 27 days in the placebo group and 29 in the treatment group (p = 0.88). ICU mortality was 4.2 % in both groups (p = 1). Sixty percent of the patients presented low glutamine levels before randomization. At the end of the treatment (6th day), 48 % of the patients maintained low glutamine levels (39 % of treated patients vs. 57 % in the placebo group). Patients with low glutamine levels at day 6 had more number of infections (58.8 vs. 80.9 %; p = 0.032) and longer ICU (9 vs. 20 days; p < 0.01) and hospital length of stay (24 vs. 41 days; p = 0.01).Conclusions
There was no benefit with i.v. l-alanyl-l-glutamine dipeptide supplementation (0.5 g/kg body weight/day of the dipeptide) during 5 days in trauma patients admitted to the ICU. The i.v. glutamine supplementation was not enough to normalize the plasma glutamine levels in all patients. Low plasma glutamine levels at day 6 were associated with a worse outcome. 相似文献2.
G Amer-Ferrer T Alonso-Marné E Diez-Tejedor A Rodriguez-Albari?o A Frank P Barreiro-Tella 《European neurology》1988,28(6):341-344
Acute confusional state following metrizamide myelography has been reported to occur in up to 2% of patients. These patients have been diagnosed as having toxic encephalopathy. Recently, various cases have been reported to have a nonconvulsive status (absence status or complex partial status) who responded well to diazepam or clonazepam therapy. However, some authors have described cases of nonresponders to anticonvulsive therapy. Failure of therapy can be dose-related. For this reason, our patient was closely monitored by EEG to determine if dose adjustment was warranted, thereby achieving good results. 相似文献
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We demonstrate by retrograde tracing methods that the transition zone between visual cortical areas 17 and 18 — where a representation of the ipsilateral visual field (IVF) has been described — projects to the IVF representation in the ipsilateral superior colliculus. The stratum griseum superficiale is the target of this retinotopically organized cortical projection to the rostral part of the superior colliculus. 相似文献
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Adrian Rodriguez Concepcion Saez-Torres Concepcion Mir Paula Casasayas Nuria Rodriguez Dolores Rodrigo Guiem Frontera Juan Manuel Buades Cristina Gomez Antonia Costa-Bauza Felix Grases 《BMC urology》2018,18(1):116
Background
The diagnosis and follow-up of stone forming patients is usually performed by analysis of 24-h urine samples. However, crystallization risk varies throughout the day, being higher at night. The main objective of this study is to evaluate the urinary crystallization risk in adults and children by calculating risk indexes based on different collection periods.Methods
The study included 149 adults (82 healthy and 67 stone-formers) and 108 children (87 healthy and 21 stone-formers). 24-h urine was collected, divided into 12-h?daytime sample (8?am to 8?pm), and 12-h overnight sample (8?pm to 8?am next morning). Solute concentrations, the calcium to citrate ratio (Ca/Cit), and the ion activity product of calcium oxalate (AP[CaOx]) and calcium phosphate (AP[CaP]) were calculated in each 12-h sample and in overall 24-h urine. Assessments were also related to stone type.Results
Ca/Cit and AP(CaOx) were significantly higher in stone forming patients than in healthy subjects. The 12-h overnight samples had the highest values for both risk indexes, confirming a greater risk for crystallization at night. The AP(CaP) index was significantly higher in patients with pure hydroxyapatite stones than healthy controls, but was not significantly different between stone-formers overall and healthy controls.Conclusions
The calculation of risk indexes is a simple method that clinicians can use to estimate crystallization risk. For this purpose, the use of 12-h overnight urine may be a reliable alternative to 24-h collections.8.
Concepción Sáez-Torres Dolores Rodrigo Félix Grases Ana M. García-Raja Cristina Gómez Javier Lumbreras Guiem Frontera 《Pediatric nephrology (Berlin, Germany)》2014,29(7):1201-1208
Background
Improving knowledge about normal urine composition in children is important for early prevention of lithiasis. We describe urinary excretion values of calcium (Ca), magnesium (Mg), phosphate (P), citrate (Cit), uric acid (Ur), and oxalate (Ox) in healthy children with and without a family history of lithiasis, using a 12-h urine collection protocol.Methods
Urine samples were obtained from 184 children (5?12 years): a spot sample collected in the afternoon, and a 12-h overnight sample. Solute/creatinine (Cr) and 12-h solute excretion was calculated.Results
Urinary excretion values of the studied solutes are presented as percentile values, separately for each type of sample. Due to age-related differences in the solute/creatinine ratios, except for Ca and Cit, results are described according to the child’s age. The presence of excretion values related to an increased risk of lithiasis was more common in children with a family history.Conclusions
We report data from urine samples collected by using a simplified collection protocol. The observed differences between children with and without a family history of lithiasis could justify that in population studies aimed at setting reference values, the former are excluded. 相似文献9.
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Ana M García-Martín Francisco J Molina-Martínez Guiem Amer-Ferrer Bernat Sureda-Ramis Antonio J Moreno-Rojas Inés Barceló-Artigues 《Epileptic Disord》2008,10(2):165-169
Autonomic signs and symptoms are a common feature of epileptic seizures. Although sympathetic activation responses are predominant, we can also find sympathetic inhibition and even an activation of the parasympathetic division of the autonomic nervous system, especially in partial seizures. These autonomic symptoms during seizures are thought to be the result of neuronal discharges arising from or spreading to cortical areas of the central autonomic network. Mydriasis, most commonly bilateral, is one of the most frequent findings. The patient described, a middle-aged man with a focal lesion in the right temporal lobe extended to the adjacent hypothalamus, presented with episodes of autonomic symptoms including prominent unilateral mydriasis, finally evolving into a state of decreased alertness. An ictal electroencephalogram and a simultaneous video recording supported the clinical impression of an epileptic aetiology. Unilateral mydriasis is a rare condition during epileptic seizures and very few cases have been reported in the past. 相似文献
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