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排序方式: 共有188条查询结果,搜索用时 31 毫秒
1.
2.
Inflammatory biomarkers in blood of patients with acute brain ischemia 总被引:11,自引:0,他引:11
S. Sotgiu B. Zanda B. Marchetti M. L. Fois G. Arru G. M. Pes F. S. Salaris A. Arru A. Pirisi G. Rosati 《European journal of neurology》2006,13(5):505-513
Although many failed surrogate markers are provided in the literature, inflammation may contribute to the outcome of ischemic stroke. In 50 consecutive patients with acute ischemic stroke, in the absence of symptoms and signs of concomitant infection, we evaluated a panel of biomarkers reported to be variably associated with brain ischemia, and correlate their serum level with the brain lesion volume and clinical outcome. Infarct size was calculated on computed tomography (CT) scans by means of the Cavalieri's method. Neurological impairment was scored by using the Glasgow Coma Scale, Glasgow Outcome Scale and National Institutes of Health (NIH) scales at stroke onset and 3-month follow-up. Some markers showed a direct significant correlation with both initial and final NIH scale and with infarct size, particularly tumor necrosis factor alpha (TNF-alpha) (P=0.002), intercellular adhesion molecule-1 (P<0.01) and matrix metalloproteinase-2/9 (P=0.001). In contrast to previous reports, interleukin-6 (IL-6) serum level showed a significant inverse correlation with both final neurological impairment and infarct size (P<0.001). This novel finding allows us suggesting that IL-6, in the context of a complex pro-inflammatory network occurring during stroke, is associated with neuroprotection rather than neurotoxicity in patients with ischemic brain injury. 相似文献
3.
Rachael Goodman-Williams Rebecca Campbell Dhruv B. Sharma Steven J. Pierce Hannah Feeney Giannina Fehler-Cabral 《Journal of trauma & dissociation》2019,20(3):288-303
ABSTRACTHundreds of thousands of previously untested sexual assault kits (SAKs) have been uncovered in police property storage facilities across the United States, representing a national failure in institutional response to sexual assault. Faced with this discovery, jurisdictions must now decide if and how they should test these kits. Some stakeholders have suggested prioritizing kits for testing by victim, offender, or assault characteristics, based on the belief that these characteristics can predict the likely utility of DNA testing. However, little research has examined the empirical merits of such prioritization. To address this gap in the literature and inform SAK testing policies, we randomly sampled 900 previously untested SAKs from Detroit, MI. The sampled SAKs were submitted for DNA testing, and eligible DNA profiles were entered into Combined DNA Index System (CODIS), the federal DNA database. Police records associated with each SAK were coded for victim, offender, and assault characteristics, and logistic regression analyses were conducted to test whether these characteristics predict which SAKs yield DNA profiles that match (“hit”) to other criminal offenses in CODIS. Testing this sample of previously-untested SAKs produced a substantial number of CODIS hits, but few of the tested variables were significant predictors of CODIS hit rate. These findings suggest that testing all previously-unsubmitted kits may generate information that is useful to the criminal justice system, while also potentially addressing the institutional betrayal victims experienced when their kits were ignored. 相似文献
4.
Intraarterial hepatic adjuvant chemotherapy after radical hepatic resection for liver metastases from colorectal carcinoma lowers the rate of liver disease relapse. The technique for catheter implantation in the right hepatic artery for subsequent intraarterial hepatic adjuvant chemotherapy after right hepatectomy is herein described and recommended as an effective alternative approach to the standard catheter implantation in the gastroduodenal artery in cases of hepatectomies for liver metastases from colorectal cancer. 相似文献
5.
Hernández-Díaz Yazmín González-Castro Thelma Beatriz Tovilla-Zárate Carlos Alfonso López-Narváez María Lilia Genis-Mendoza Alma Delia Castillo-Avila Rosa Giannina Ramos-Méndez Miguel Ángel Juárez-Rojop Isela Esther 《Metabolic brain disease》2021,36(8):2415-2424
Metabolic Brain Disease - Schizophrenia is a debilitating mental illness. Levels of oxytocin have been proposed as a biomarker of schizophrenia; however, the observed levels of oxytocin in... 相似文献
6.
A. Varcasia A. P. Pipia D. Arru A. M. Pes C. Tamponi F. Dore G. Garippa A. Scala 《Parasitology research》2013,112(5):2079-2082
Coenurosis is a central nervous system disease of wild and domestic ruminants caused by Coenurus cerebralis, a bladder worm stage of Taenia multiceps). Even in Sardinia island, this metacestode seems to be widespread in sheep (Scala et al. Vet Parasitol 143(3–4):294–298, 2007) where coenurosis is an important health problem (Varcasia et al. Parasitol Res 99(5):622–626, 2006) the last and unique report of coenurosis in cattle was in 1990 (Cubeddu et al. 1990). In the present paper, a case of bovine coenurosis in Sardinia was described 22 years after the first report with a morphological a biomolecular characterization. A 2-year-old Limousine bull was euthanized in the Bolotana (NU) municipality (Central Sardinia). The remote anamnesis achieved from the farmer reporting that the bull showed neurological symptoms from 1 year of age previously classified as nutritional problems by the farm’s veterinary. The breeder also says that the bull have by self-produced the skull fracture by hitting a gaff in the farm. The skull was opened and the brain removed and carefully examined showing two coenurus cysts containing clear fluid with numerous scoleces both in the right hemisphere. Morphological features of the cysts and mt-DNA sequencing confirm that the parasites were T. multiceps Coenuri. 相似文献
7.
8.
Olivier Facy Vito De Blasi Martine Goergen Luca Arru Luigi De Magistris Juan-Santiago Azagra 《Surgical endoscopy》2013,27(10):3841-3845
Background
Intestinal anastomosis is a complex procedure during laparoscopy, mainly due to the difficulties knotting the sutures. Unidirectional barbed sutures have been proposed to simplify wall and mesentery closure, but the results for intestinal anastomosis are not clear. This study aimed to establish the feasibility and the safety of laparoscopic intestinal anastomosis using barbed suture.Methods
Between June 2011 and May 2012, 15-cm-long unidirectional absorbable barbed sutures (V-Loc; Covidien, Mansfield, MA, USA) were used for all laparoscopic intestinal anastomoses: one suture for closure of intestinal openings after mechanical anastomoses and two sutures for hand-sewn anastomoses.Results
Over a 1-year period, 201 consecutive patients required 220 laparoscopic anastomoses for gastrojejunostomy (n = 177; 172 during Roux-en-Y gastric bypass and 5 after gastrectomy), ileocolostomy (n = 15), colocolostomy (n = 1), esophagojejunostomy (n = 5), and jejunojejunostomy (n = 22; 4 after small bowel resection and 18 during gastric bypass or gastrectomy). Senior and training surgeons performed 209 closures of intestinal openings and 11 hand-sewn anastomoses. There was no conversion to usual sutures. One fistula occurred in an esophagojejunostomy and was managed conservatively. One self-limited anastomotic bleeding occurred, and no anastomotic stenosis occurred during 6 months of follow-up evaluation.Conclusions
The use of knotless barbed suture for laparoscopic intestinal anastomosis is safe and reproducible. 相似文献9.
Luca Aldrighetti Carlo Pulitanò Marco Catena Marcella Arru Eleonora Guzzetti Massimiliano Casati Laura Comotti Gianfranco Ferla 《Journal of gastrointestinal surgery》2008,12(3):457-462
Background Left lateral sectionectomy is one of the most commonly performed laparoscopic liver resections, but limited clinical data
are actually available to support the advantage of laparoscopic versus open-liver surgery. The present study compared the
short-term outcomes of laparoscopic versus open surgery in a case-matched analysis.
Materials and Methods Surgical outcome of 20 patients who underwent left lateral sectionectomy by laparoscopic approach (LHR group) from September
2005 to January 2007 were compared in a case-control analysis with those of 20 patients who underwent open left lateral sectionectomy
(OHR group). Both groups were similar for: tumor size, preoperative laboratory data, presence of cirrhosis, and histology
of the lesion. Surgical procedures were performed in both groups combining the ultrasonic dissector and the ultrasonic coagulating
cutter without portal clamping.
Results Compared with OHR, the LHR group had a decreased blood loss (165 mL versus 214 mL, P = 0.001), and earlier postoperative recovery (4.5 versus 5.8 days, P = 0.003). There were no significant differences in terms of surgical margin and operative time. Morbidity was comparable
between the two groups, but two cases of postoperative ascites were recorded in two cirrhotic patients in the OHR. Major complications
were not observed in either groups.
Conclusions Laparoscopic resection results in reduced operative blood loss and earlier recovery with oncologic clearance and operative
time comparable with open surgery. Laparoscopic liver surgery may be considered the approach of choice for tumors located
in the left hepatic lobe. 相似文献
10.
Luca Aldrighetti MD Carlo Pulitanò MD Marco Catena MD Marcella Arru MD Eleonora Guzzetti MD Jane Halliday MD Gianfranco Ferla MD 《Annals of surgical oncology》2009,16(5):1254-1254
Introduction Hepatocellular carcinoma (HCC) tends to invade the intrahepatic vasculature, especially the portal vein.1 The presence of portal vein tumor thrombus (PVTT) in patients with HCC is one of the most significant factors for a poor
prognosis.2
–
5 The presence of macroscopic PVTT in patients with HCC is also a significant factor for poor prognosis, with a median survival
of <3 months without treatment.1 In surgically resected series, in patients with gross PVTT (PVTT in the portal trunk, its first-order branch, or its second-order
branch), the 3-year and 5-year survival rates are reportedly 15% to 28% and 0% to 17%, respectively.2
–
5
Methods The patient was a 77-year-old woman with well-compensated hepatitis C virus–related cirrhosis (stage A6 according to Child-Pugh
classification) who sought care at our department for vague abdominal discomfort. Triphasic spiral computed tomographic scan
confirmed HCC 6 cm in diameter in the left lobe of the liver. In addition, portal vein tumor thrombosis of the left branch
that extended to the right portal vein was present.
Results The procedure included left hepatectomy and en-bloc portal vein thrombectomy with clamping of both the common portal vein
trunk and the right portal vein. The portal vein was incised at the bifurcation of the right and left portal veins, and the
thrombus was extracted from the incision in the portal vein. With this procedure, we were able to examine under direct vision
the exact extent of the portal vein thrombus, and we identified whether the tumor thrombus was adherent to the venous wall
or was freely floating in the venous lumen.
Portal clamping and length of operation were 16 and 330 minutes, respectively. Intraoperative blood loss was 550 mL. The
patient was discharged on postoperative day 6, and she was free of disease at 15 months after surgery.
Discussion Liver resection should be considered a valid therapeutic option for HCC with PVTT.
Electronic supplementary material The online version of this article (doi:) contains supplementary video material, which is available to authorized users.
Presented to Annual Meeting of the American Hepato-Pancreato-Biliary Association (AHPBA), Miami, Florida, USA, March 9-12,
2006. 相似文献