收费全文 | 207398篇 |
免费 | 4865篇 |
国内免费 | 503篇 |
耳鼻咽喉 | 2887篇 |
儿科学 | 7858篇 |
妇产科学 | 6099篇 |
基础医学 | 26700篇 |
口腔科学 | 6210篇 |
临床医学 | 16242篇 |
内科学 | 38205篇 |
皮肤病学 | 4797篇 |
神经病学 | 13061篇 |
特种医学 | 10943篇 |
外国民族医学 | 97篇 |
外科学 | 31196篇 |
综合类 | 1134篇 |
一般理论 | 5篇 |
预防医学 | 17147篇 |
眼科学 | 4534篇 |
药学 | 14143篇 |
2篇 | |
中国医学 | 189篇 |
肿瘤学 | 11317篇 |
2021年 | 669篇 |
2018年 | 4005篇 |
2017年 | 4243篇 |
2016年 | 3529篇 |
2015年 | 5224篇 |
2014年 | 4808篇 |
2013年 | 4040篇 |
2012年 | 10856篇 |
2011年 | 5730篇 |
2010年 | 2726篇 |
2009年 | 4337篇 |
2008年 | 2799篇 |
2007年 | 3521篇 |
2006年 | 3784篇 |
2005年 | 11817篇 |
2004年 | 13194篇 |
2003年 | 8758篇 |
2002年 | 3897篇 |
2001年 | 4586篇 |
2000年 | 1977篇 |
1999年 | 6029篇 |
1998年 | 593篇 |
1992年 | 6931篇 |
1991年 | 7168篇 |
1990年 | 7383篇 |
1989年 | 6998篇 |
1988年 | 6502篇 |
1987年 | 6256篇 |
1986年 | 5981篇 |
1985年 | 5267篇 |
1984年 | 3632篇 |
1983年 | 2933篇 |
1982年 | 1016篇 |
1981年 | 787篇 |
1980年 | 849篇 |
1979年 | 3846篇 |
1978年 | 2371篇 |
1977年 | 1791篇 |
1976年 | 1568篇 |
1975年 | 2480篇 |
1974年 | 3123篇 |
1973年 | 2749篇 |
1972年 | 2767篇 |
1971年 | 2748篇 |
1970年 | 2557篇 |
1969年 | 2472篇 |
1968年 | 2241篇 |
1967年 | 2176篇 |
1966年 | 1905篇 |
1965年 | 1135篇 |
Background
Since recent reports have shown that (-)-Epigallocatechin-3-gallate (EGCG) could be used for treating proliferative and inflammatory disorders, we explored its use for the management of corneal chemical burns.Materials and methods
Initially, EGCG was assayed on the rabbit corneal epithelial cell line RCE1(5T5) to establish the best testing conditions, and to avoid unwanted outcomes in the experimental animals. Then, we studied its effects on cell proliferation, cell cycle progression and cell differentiation. Afterwards, we instilled EGCG in experimental grade II corneal alkali burns in mice, three times a day up to 21 days, and evaluated by slit lamp examination and histological sections of corneal epithelial, corneal endothelial and stromal edema, as well as the presence of inflammatory cells and neovascularization.Results
EGCG reduced cell growth and led to a decline in the proportion of proliferative cells in a concentration dependent manner. At 10 μM, EGCG promoted cell differentiation, an effect not related with apoptosis or cytotoxicity. When 10 μM EGCG was instilled in corneal alkali burns in mice three times a day up to 21 days, EGCG significantly reduced corneal opacity and neovascularization. The improved clinical appearance of the cornea was associated to a controlled epithelial growth; epithelial morphology was similar to that observed in normal epithelium and contrasted with the hyperproliferative, desquamating epithelium observed in control burn wounds. EGCG reduced corneal, stromal and endothelial edema, and wound inflammation.Conclusion
This work constitutes the first evidence for the use of EGCG in the acute phase of a corneal alkali burn, representing a possible novel alternative to improve patient outcomes as an add-on therapy. 相似文献Material and methods: original research studies were searched from seven databases (MEDLINE, EMBASE, CENTRAL, CINAHL, SCOPUS, PEDro and PubMed). Subsequently, two independent reviewers screened the titles and abstracts followed by full-text reviews to assess the studies' eligibility.
Results: eleven studies met the inclusion criteria and had data abstracted and quality assessed. Methodology varied considerably and yet cognitive tasks resulted in the ΔO2Hb increasing in 8 of the 11 and ΔHHb decreasing in 8 of 8 studies that reported this outcome. The cognitive tasks from 10 of the 11 studies were classified as “Working Memory” and “Verbal Fluency Tasks”.
Conclusions: although, the data comparison was challenging provided the heterogeneity in methodology, the results across studies were similar. 相似文献