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Besma Hamdi Emna Ben Jemia Monia Attia Ikbel Khalfallah Hend Riahi Anissa Berraies Mohamed Faouzi Ladeb Soumaya Rammeh Agnes Hamzaoui 《Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders》2022,39(3)
Sarcoidosis is a multisystem disease of unknown origin. Diagnosis remains challenging, based on organ site involvement, histological confirmation of non-caseating granuloma and an appropriate clinical syndrome. Granulomatous bone involvement is rare and may be ignored because it is usually asymptomatic. Vertebrae, ribs and skull localizations are rarely reported. We described an interesting case of a woman with chronic and multiorgan sarcoidosis with unusual bone localizations. 相似文献
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IntroductionPedagogical workshop planning is challenging especially when we aim to promote a reflective practice of the tutees. This practice has been widely discussed in the literature without a real consensus. Some authors reported oral exercises or anecdotes, other described writings or even storytelling. The aim of the authors was to describe the different steps performed by the tutors and to assess the tutees’ satisfaction.Material and methodsThis was a pilot study dealing with the use of the prospective strategy principles in order to plan a pedagogical workshop. Included participants were early academic teacher trainees.ResultsThe authors illustrated how they planned a pedagogical workshop using the prospective strategy and highlighted the satisfaction of the tutees.ConclusionProspective strategy is mainly used in economic field in order to change the future of the companies by acting on different intervening factors. Associating prospective strategy to pedagogical principles hasn’t been reported in the medical literature and seems to be available in order to induce reflective practice. 相似文献
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Background and Purpose
Kv1.3 potassium channels are promising pharmaceutical targets for treating immune diseases as they modulate Ca2+ signalling in T cells by regulating the membrane potential and with it the driving force for Ca2+ influx. The antimycobacterial drug clofazimine has been demonstrated to attenuate antigen‐induced Ca2+ oscillations, suppress cytokine release and prevent skin graft rejection by inhibiting Kv1.3 channels with high potency and selectivity.Experimental Approach
We used patch‐clamp methodology to investigate clofazimine''s mechanism of action in Kv1.3 channels expressed in HEK293 cells.Key Results
Clofazimine blocked Kv1.3 channels by involving two discrete mechanisms, both of which contribute to effective suppression of channels: (i) a use‐dependent open‐channel block during long depolarizations, resulting in accelerated K+ current inactivation and (ii) a block of closed deactivated channels after channels were opened by brief depolarizations. Both modes of block were use‐dependent and state‐dependent in that they clearly required prior channel opening. The clofazimine‐sensitive closed‐deactivated state of the channel was distinct from the resting closed state because channels at hyperpolarized voltages were not inhibited by clofazimine. Neither were channels in the C‐type inactivated state significantly affected. Kv1.3 channels carrying the H399T mutation and lacking C‐type inactivation were insensitive to clofazimine block of the closed‐deactivated state, but retained their susceptibility to open‐channel block.Conclusions and Implications
Given the prominent role of Kv1.3 in shaping Ca2+ oscillations, the use‐dependent and state‐dependent block of Kv1.3 channels by clofazimine offers therapeutic potential for selective immunosuppression in the context of autoimmune diseases in which Kv1.3‐expressing T cells play a significant role.Abbreviations
- CLF
- clofazimine
- FDA
- Food and Drug Administration
- IPI
- interpulse intervals
- WT
- wild type
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Pneumocystis carinii pneumonia in patients with hematologic malignancies: a descriptive study 总被引:3,自引:0,他引:3
Roblot F Le Moal G Godet C Hutin P Texereau M Boyer E Prazuck T Lacroix C Souala MF Raffi F Weinbreck P Besnier JM Garo B de Gentile L Becq-Giraudon B 《The Journal of infection》2003,47(1):19-27
Objectives. A retrospective multicentric study was conducted over a five-year period to evaluate the clinical and laboratory characteristics and outcome of patients with proven Pneumocystis carinii pneumonia (PCP) complicating hematologic malignancies.Results. The study included 60 HIV-negative patients with 18 non-Hodgkin's malignant lymphoma (30%), 13 chronic lymphocytic leukaemia (21.7%), 10 acute leukemia (16.6%), 5 multiple myeloma (8.3%), 4 Waldenstr?m's diseases (6.6%), 4 chronic myeloid leukemia (6.6%), 3 myelodysplasia (5%), 2 Hodgkin's diseases (3.3%) and 1 thrombopenia. Bronchoalveolar lavage was diagnostic in all patients. Forty-nine patients received cytotoxic drugs (81.7%), 25 (41.7%) a long-term corticotherapy and 15 (25%) underwent bone marrow transplantation. Twenty-seven patients (45%) required admission in the intensive care unit, 35 (58.3%) received an adjunctive corticotherapy and 18 mechanical ventilation (30%). Twenty patients (33.3%) died of PCP. A previous long-term corticotherapy (p=0.04), high respiratory (p=0.05) and pulse rates (p=0.02), elevated C reactive protein (p=0.01) and mechanical ventilation (OR=13.37; IC: 1.9-50) were associated with a poor prognosis. Adjunctive corticotherapy did not modify the prognosis.Conclusions. These results suggest that PCP can occur during the course of various hematologic malignancies, not only lymphoproliferative disorders. Prognosis remains poor. The diagnosis should be advocated more frequently and earlier to improve the prognosis. 相似文献