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Anwesan De Kailash P. Bhatia MD FRCP Jens Volkmann MD PhD FEAN Robert Peach PhD Sebastian R. Schreglmann MD PhD FEBN 《Movement disorders》2023,38(5):717-731
Tremor is the most frequent human movement disorder, and its diagnosis is based on clinical assessment. Yet finding the accurate clinical diagnosis is not always straightforward. Fine-tuning of clinical diagnostic criteria over the past few decades, as well as device-based qualitative analysis, has resulted in incremental improvements to diagnostic accuracy. Accelerometric assessments are commonplace, enabling clinicians to capture high-resolution oscillatory properties of tremor, which recently have been the focus of various machine-learning (ML) studies. In this context, the application of ML models to accelerometric recordings provides the potential for less-biased classification and quantification of tremor disorders. However, if implemented incorrectly, ML can result in spurious or nongeneralizable results and misguided conclusions. This work summarizes and highlights recent developments in ML tools for tremor research, with a focus on supervised ML. We aim to highlight the opportunities and limitations of such approaches and provide future directions while simultaneously guiding the reader through the process of applying ML to analyze tremor data. We identify the need for the movement disorder community to take a more proactive role in the application of these novel analytical technologies, which so far have been predominantly pursued by the engineering and data analysis field. Ultimately, big-data approaches offer the possibility to identify generalizable patterns but warrant meaningful translation into clinical practice. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 相似文献
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Jobert Richie Nansseu MD Aurel T. Tankeu MD Joseph Kamtchum‐Tatuene MD MAS MRes FEBN Jean Jacques Noubiap MD 《Journal of clinical hypertension (Greenwich, Conn.)》2018,20(1):168-173
Cardiovascular disease (CVD) has become a major concern in low‐ and middle‐income countries, which bear about 80% of the cardiovascular mortality worldwide. Curbing the burden of CVD implies the management and control of many cardiovascular risk factors that act synergistically to increase cardiovascular mortality. Such actions may require expensive polymedications in a context of limited resources. Therefore, alternative solutions for CVD prevention in low‐ and middle‐income countries are urgently needed. In this context, the concept of a fixed‐dose combination therapy, a polypill composed of drugs known to effectively treat or prevent CVD, has been proposed as a scalable strategy to overcome nonadherence to polymedications and reduce costs. While this has recently been approved in more than 30 countries across America and Europe, there is a crucial need to analyze the potential benefits and challenges related to cardiovascular polypills implementation and vulgarization in low‐ and middle‐income countries, the epicenter of CVD. 相似文献
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Eman Hamid MD Kigocha Okengo MSc Biniyam A. Ayele MD Daniel Gams Massi MD Samia Ben Sassi MD Houyam Tibar MD Sarah Misbah El-Sadig MD MRCP FRCP Soulaimane Mahoui MDDCh Julien Razafimahefa MD MSc Ange Eric Kouame-Assouan MD Djibrilla Ben-Adji MD Lengane Y.T. Modeste MD Muhyadin Hassan Mohamed MBBCh MSc. MHSM Nestor Nsengiyumva MD Wael Abdulgader Alwahchi MBSS Saara Ndinelago Neshuku MBChB FCN MMED Neurology Cassandra Ocampo MD Foksouna Sakadi MD João Bilardo Caiano MD Antonia Rodrigues Fortes MSc Maouly Fall MD Gift Wilson Ngwende MBChB MMed FEBN Juzar Hooker MB ChB MMeD DCN FCP Augustina Charway-Felli MD PhD Masharip Atadzhanov MD PhD MSc Jonathan Carr PhD MBCHB Njideka U. Okubadejo MBCHB MD FMCP Ali Shalash MD PhD 《Movement disorders》2023,38(2):178-184
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