全文获取类型
收费全文 | 6508篇 |
免费 | 388篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 155篇 |
妇产科学 | 205篇 |
基础医学 | 799篇 |
口腔科学 | 161篇 |
临床医学 | 539篇 |
内科学 | 1364篇 |
皮肤病学 | 55篇 |
神经病学 | 550篇 |
特种医学 | 534篇 |
外科学 | 1009篇 |
综合类 | 70篇 |
预防医学 | 403篇 |
眼科学 | 212篇 |
药学 | 487篇 |
中国医学 | 26篇 |
肿瘤学 | 305篇 |
出版年
2022年 | 73篇 |
2021年 | 111篇 |
2020年 | 81篇 |
2019年 | 87篇 |
2018年 | 117篇 |
2017年 | 87篇 |
2016年 | 101篇 |
2015年 | 124篇 |
2014年 | 154篇 |
2013年 | 196篇 |
2012年 | 342篇 |
2011年 | 361篇 |
2010年 | 189篇 |
2009年 | 208篇 |
2008年 | 279篇 |
2007年 | 323篇 |
2006年 | 299篇 |
2005年 | 339篇 |
2004年 | 304篇 |
2003年 | 274篇 |
2002年 | 276篇 |
2001年 | 171篇 |
2000年 | 202篇 |
1999年 | 141篇 |
1998年 | 62篇 |
1997年 | 46篇 |
1995年 | 45篇 |
1994年 | 40篇 |
1993年 | 44篇 |
1992年 | 120篇 |
1991年 | 83篇 |
1990年 | 103篇 |
1989年 | 98篇 |
1988年 | 113篇 |
1987年 | 91篇 |
1986年 | 63篇 |
1985年 | 86篇 |
1984年 | 61篇 |
1983年 | 78篇 |
1981年 | 41篇 |
1979年 | 50篇 |
1978年 | 47篇 |
1977年 | 38篇 |
1975年 | 51篇 |
1974年 | 66篇 |
1972年 | 57篇 |
1971年 | 51篇 |
1970年 | 42篇 |
1968年 | 38篇 |
1967年 | 40篇 |
排序方式: 共有6920条查询结果,搜索用时 0 毫秒
1.
Characteristics of hyperparathyroid states in the Canadian multicentre osteoporosis study (CaMos) and relationship to skeletal markers
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
3.
4.
5.
6.
7.
8.
9.
Pharmacokinetics and pharmacodynamics of benazepril hydrochloride in patients with major proteinuria
Ch. Schweizer G. Kaiser W. Dieterle J. Mann 《European journal of clinical pharmacology》1993,44(5):463-466
Summary We have investigated whether the pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride are altered with proteinuria by studying 8 patients with major proteinuria of different causes who were given a single dose of 10 mg p.o.The maximum plasma concentration of benazepril was found between 0.5 and 2 h after dosing (median 1 h). Its elimination was almost complete within 6 h. Peak plasma levels of benazeprilat, the active metabolite of benazepril, were observed between 1 and 6 h (median 2.5 h). The elimination of benazeprilat from plasma was biphasic, with mean initial and terminal half-lives of 3.0 and 17.3 h, respectively. On average, the pharmacokinetic parameters of benazepril and benazeprilat in the patients did not differ from those in a historical control group of healthy volunteers, but intersubject variability in the AUC and half-lives of benazeprilat was greater in the patients.Plasma ACE was completely inhibited from 1.5 to 6 h after dosing, and at 48 h the mean inhibition was still 42 %. Plasma renin showed substantial intersubject variation. Mean supine blood pressure (systolic/diastolic) was reduced from baseline by a maximum of 18/13 mm Hg at 6 h. Proteinuria was diminished after benazepril in 7 patients.In conclusion, the results of this study suggest that proteinuria in the nephrotic range does not require a change in benazepril dosage. 相似文献
10.
Pharmacological properties of fluphenazine-mustard, an irreversible calmodulin antagonist 总被引:1,自引:0,他引:1
We describe an improved synthesis and properties of fluphenazine-mustard, a potent phenothiazine having an alkylating chlorethylamine chain in its structure. The drug possesses anticalmodulin activity equivalent to the parent compound, but unlike fluphenazine dihydrochloride, the mustard derivative irreversibly antagonizes the ability of calmodulin to activate cyclic nucleotide phosphodiesterase. This property is partially calcium-dependent and can be overcome by coincubation with excess fluphenazine dihydrochloride. The compound irreversibly inactivated calmodulin when incubated with intact cells and caused single-stranded breakage of DNA. Fluphenazine-mustard possesses potent antiproliferative and cytotoxic properties against malignant cell lines that are likely to be mediated through both of these actions. 相似文献