全文获取类型
收费全文 | 10719篇 |
免费 | 743篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 106篇 |
儿科学 | 365篇 |
妇产科学 | 217篇 |
基础医学 | 1492篇 |
口腔科学 | 253篇 |
临床医学 | 1608篇 |
内科学 | 2049篇 |
皮肤病学 | 148篇 |
神经病学 | 1033篇 |
特种医学 | 157篇 |
外科学 | 918篇 |
综合类 | 111篇 |
一般理论 | 19篇 |
预防医学 | 1412篇 |
眼科学 | 111篇 |
药学 | 825篇 |
中国医学 | 36篇 |
肿瘤学 | 622篇 |
出版年
2023年 | 72篇 |
2022年 | 86篇 |
2021年 | 215篇 |
2020年 | 157篇 |
2019年 | 218篇 |
2018年 | 275篇 |
2017年 | 202篇 |
2016年 | 199篇 |
2015年 | 236篇 |
2014年 | 354篇 |
2013年 | 526篇 |
2012年 | 679篇 |
2011年 | 826篇 |
2010年 | 473篇 |
2009年 | 378篇 |
2008年 | 742篇 |
2007年 | 741篇 |
2006年 | 751篇 |
2005年 | 722篇 |
2004年 | 676篇 |
2003年 | 565篇 |
2002年 | 572篇 |
2001年 | 125篇 |
2000年 | 109篇 |
1999年 | 138篇 |
1998年 | 139篇 |
1997年 | 94篇 |
1996年 | 90篇 |
1995年 | 75篇 |
1994年 | 74篇 |
1993年 | 72篇 |
1992年 | 77篇 |
1991年 | 65篇 |
1990年 | 58篇 |
1989年 | 62篇 |
1988年 | 46篇 |
1987年 | 54篇 |
1986年 | 34篇 |
1985年 | 41篇 |
1984年 | 43篇 |
1983年 | 35篇 |
1982年 | 47篇 |
1981年 | 47篇 |
1980年 | 43篇 |
1979年 | 37篇 |
1978年 | 43篇 |
1977年 | 19篇 |
1975年 | 19篇 |
1974年 | 20篇 |
1973年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
Richard Kim Elaine Tan Emily Wang Amit Mahipal Dung-Tsa Chen Biwei Cao Fadzai Masawi Cindy Machado James Yu Dae Won Kim 《The oncologist》2020,25(12):e1893-e1899
Lessons Learned
- The combination of trametinib and sorafenib has an acceptable safety profile, albeit at doses lower than approved for monotherapy.
- Maximum tolerated dose is trametinib 1.5 mg daily and sorafenib 200 mg twice daily.
- The limited anticancer activity observed in this unselected patient population does not support further exploration of trametinib plus sorafenib in patients with hepatocellular carcinoma.
2.
Julia H. Vermylen Gordon J. Wood Elaine R. Cohen Jeffrey H. Barsuk William C. McGaghie Diane B. Wayne 《Journal of pain and symptom management》2019,57(3):682-687
Introduction
Physician communication impacts patient outcomes. However, communication skills, especially around difficult conversations, remain suboptimal, and there is no clear way to determine the validity of entrustment decisions. The aims of this study were to 1) describe the development of a simulation-based mastery learning (SBML) curriculum for breaking bad news (BBN) conversation skills and 2) set a defensible minimum passing standard (MPS) to ensure uniform skill acquisition among learners.Innovation
An SBML BBN curriculum was developed for fourth-year medical students. An assessment tool was created to evaluate the acquisition of skills involved in a BBN conversation. Pilot testing was completed to confirm improvement in skill acquisition and set the MPS.Outcomes
A BBN assessment tool containing a 15-item checklist and six scaled items was developed. Students' checklist performance improved significantly at post-test compared to baseline (mean 65.33%, SD = 12.09% vs mean 88.67%, SD = 9.45%, P < 0.001). Students were also significantly more likely to have at least a score of 4 (on a five-point scale) for the six scaled questions at post-test. The MPS was set at 80%, requiring a score of 12 items on the checklist and at least 4 of 5 for each scaled item. Using the MPS, 30% of students would require additional training after post-testing.Comments
We developed a SBML curriculum with a comprehensive assessment of BBN skills and a defensible competency standard. Future efforts will expand the mastery model to larger cohorts and assess the impact of rigorous education on patient care outcomes. 相似文献3.
4.
5.
6.
K. A. Harding M. E. Pushpanathan S. R. Whitworth S. Nanthakumar R. S. Bucks T. C. Skinner 《Diabetic medicine》2019,36(12):1600-1611
7.
Justin E. Karr Holly K. Rau Jane B. Shofer Rebecca C. Hendrickson Elaine R. Peskind Kathleen F. Pagulayan 《Journal of clinical and experimental neuropsychology》2019,41(7):680-693
Introduction: This study investigated variables associated with subjective decline in executive function among Veterans of Operations Enduring Freedom, Iraqi Freedom, and New Dawn (OEF/OIF/OND) following a history of blast-related mild traumatic brain injury (mTBI).Method: Fifty-six male U.S. Veterans (MAge = 35.3 ± 8.8 years) with a history of blast-related mTBI (6.6 ± 3.2 years post injury) completed a battery of self-report questionnaires and neuropsychological measures. Participants rated current and retrospectively estimated pre-mTBI executive function difficulties on the Frontal Systems Behavior Scale (FrSBe). A difference score (post- minus pre-mTBI ratings) was the dependent variable (?FrSBe). Linear regression models examined variables predicting ?FrSBe, including: pre-injury characteristics (education, premorbid intelligence), injury-related characteristics (number of blast exposures, losses of consciousness), post-injury clinical symptoms (PTSD Checklist–Military version; Pittsburgh Sleep Quality Index), and post-injury neuropsychological performances on executive function measures (Trail Making Test Part B; Controlled Oral Word Association Test; Auditory Consonant Trigrams; Wisconsin Card Sorting Test).Results: While 11% of participants had a clinically elevated pre-injury FrSBe total score, 82% had a clinically elevated post-injury FrSBe total score. Only self-reported PTSD symptom severity independently predicted perceived change in executive function.Conclusions: Many OEF/OIF/OND Veterans with a history of blast-related mTBI experience subjective decline in executive function following injury. Perceived executive function decline was associated with higher PTSD symptom severity, aligning with previous research associating PTSD with cognitive complaints. Results did not support a correspondence between perceived cognitive change and neuropsychological performances. 相似文献
8.
Kristina W. Whitworth Brenda Berumen-Flucker George L. Delclos Sonia Fragoso Claudia Mata David Gimeno Ruiz de Porras 《Archives of environmental & occupational health》2020,75(2):70-74
AbstractThe occupational hazards and respiratory symptoms of domestic cleaners in USA are largely unknown. We conducted a cross-sectional study among 56 Hispanic female domestic cleaner on their health status and frequency of cleaning products used and tasks performed. While women used multi-use products (60.0%) and toilet bowl cleaners (51.8%) most days of the week, many (39.3%) reported not using personal protective equipment while cleaning. Itchy/watery eyes (61.8%) and itchy nose (56.4%) were the most frequently reported symptoms. A history of physician-diagnosed asthma was reported by 14.3% while 33.9% had symptoms of bronchial hyperresponsiveness (BHR). In conclusion, this vulnerable population has high prevalence of physician-diagnosis asthma and BHR symptoms and is potentially exposed to myriad occupational hazards. Further research exploring associations between products use, cleaning tasks and respiratory symptoms is warranted. 相似文献
9.
Maren T Scheuner William C Whitworth Henraya McGruder Paula W Yoon Muin J Khoury 《Genetics in medicine》2006,8(8):525-531
PURPOSE: We examined the performance of a familial risk assessment method that stratifies risk for early-onset coronary heart disease by considering the number of relatives with coronary disease, degree of relationship, lineage, and age at diagnosis. METHODS: By using data from the HealthStyles 2003 survey, we assessed the associations between familial risk and early-onset coronary heart disease, diabetes, hypercholesterolemia, hypertension, and obesity. By using area under the curve statistics, we evaluated the discriminatory ability of various risk assessment models. RESULTS: Of 4,035 respondents, 60% were female and 72% were white, with a mean age of 48.8 years. After adjustment for demographics, strong and moderate risk were significantly associated with approximately a five- and twofold risk of early-onset coronary disease, respectively. After adjustment for demographics and personal history of cardiovascular disease, strong familial risk was also significantly associated with diabetes, hypercholesterolemia, hypertension, and obesity. A risk assessment model that included familial risk, demographics, and personal history of diabetes, hypercholesterolemia, hypertension, and obesity was most optimal with an area under the curve statistic of 87.2% CONCLUSIONS: Familial risk assessment can stratify risk for early-onset coronary heart disease. Several conditions associated with increased familial risk can be prevented. These results have important implications for risk assessment and risk-reducing interventions. 相似文献
10.
Michael K. Gardner Elaine Clark Mary Ann C. Bowman Patrick J. Miller 《Alcoholism, clinical and experimental research》1989,13(4):508-511
This study investigated analogical reasoning abilities of alcoholics who had been abstinent from alcohol for at least 1 year. Their performance was compared to that of nonalcoholic controls matched as a group for education, age, and gender. Solution times and error rates were modeled using a regression model. Results showed a nonsignificant trend for alcoholics to be faster, but more error prone, than controls. The same componential model applied to both groups, and fit them equally well. Although differences have been found in analogical reasoning ability between controls and alcoholics immediately following detoxification, we find no evidence of differences after extended periods of sobriety. 相似文献