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Lee Dongwhane Lee Deok Hee Suh Dae Chul Kwon Hyuk Sung Jeong Da-Eun Kim Joong-Goo Lee Ji-Sung Kim Jong S. Kang Dong-Wha Jeon Sang-Beom Lee Eun-Jae Noh Kyung Chul Kwon Sun U. 《Journal of neurology》2019,266(9):2286-2293
Journal of Neurology - This study aimed to evaluate the efficacy of intra-arterial thrombectomy (IAT) and prognosis for acute ischaemic stroke patients with active cancer. We retrospectively... 相似文献
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Kwon Hyuk Sung Lee Dongwhane Lee Min Hwan Yu Sungwook Lim Jae-Sung Yu Kyung-Ho Oh Mi Sun Lee Ji-Sung Hong Keun-Sik Lee Eun-Jae Kang Dong-Wha Kwon Sun U. 《Journal of neurology》2020,267(3):688-693
Journal of Neurology - To devise appropriate preventive strategies after stroke, knowledge of the association between post-stroke cognitive impairment (PSCI) and prognosis of stroke patients is... 相似文献
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Dongwhane Lee Sung Hyuk Heo Sung-Sang Yoon Dae-Il Chang Sangeui Lee Hak-Young Rhee Bon D. Ku Key-Chung Park 《JOURNAL OF CLINICAL NEUROLOGY》2014,10(4):304-313
Background and Purpose
We examined the characteristics of sleep disturbances and sleep patterns in the caregivers of patients with amnestic mild cognitive impairment (aMCI) and dementia.Methods
We prospectively studied 132 patients (60 with aMCI and 72 with dementia) and their caregivers, and 52 noncaregiver controls. All caregivers and controls completed several sleep questionnaires, including the Pittsburgh Sleep Quality Index (PSQI). The patients were administered neuropsychological tests and the neuropsychiatric inventory to evaluate their behavioral and neuropsychiatric symptoms of dementia (BPSD).Results
The PSQI global score was 6.25±3.88 (mean±SD) for the dementia caregivers and 5.47±3.53 for the aMCI caregivers. The Insomnia Severity Index (ISI) and short form of the Geriatric Depression Scale (GDS-S) predicted higher PSQI global scores in aMCI caregivers, and higher scores for the ISI, Epworth Sleepiness Scale (ESS), and GDS-S in dementia caregivers. BPSD, including not only agitation, depression, and appetite change in dementia patients, but also depression, apathy, and disinhibition in aMCI patients, was related to impaired sleep quality of caregivers, but nighttime behavior was not. Age and gender were not risk factors for disturbed sleep quality.Conclusions
Dementia and aMCI caregivers exhibit impaired quality of sleep versus non-caregivers. ISI, GDS-S, and ESS scores are strong indicators of poor sleep in dementia caregivers. In addition, some BPSD and parts of the neuropsychological tests may be predictive factors of sleep disturbance in dementia caregivers. 相似文献5.
Pil Hyung Lee Jae-Kwan Song Jong S. Kim Ran Heo Sahmin Lee Dae-Hee Kim Jong-Min Song Duk-Hyun Kang Sun U. Kwon Dong-Wha Kang Dongwhane Lee Hyuk Sung Kwon Sung-Cheol Yun Byung Joo Sun Jae-Hyeong Park Jae-Hwan Lee Hye Seon Jeong Hee-Jung Song Seung-Jung Park 《Journal of the American College of Cardiology》2018,71(20):2335-2342
Background
Recent reports showing the favorable role of patent foramen ovale (PFO) closure in patients with cryptogenic stroke have raised the issue of selecting optimal candidates.Objectives
This study, DEFENSE-PFO (Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale), evaluated whether the benefits of PFO closure can be determined on the basis of the morphologic characteristics of the PFO, as evaluated by transesophageal echocardiography.Methods
Patients with cryptogenic stroke and high-risk PFO were divided between a transcatheter PFO closure and a medication-only group. High-risk PFO included PFO with atrial septal aneurysm, hypermobility (phasic septal excursion into either atrium ≥10 mm), or PFO size (maximum separation of the septum primum from the secundum) ≥2 mm. The primary endpoint was a composite of stroke, vascular death, or Thrombolysis In Myocardial Infarction–defined major bleeding during 2 years of follow-up.Results
From September 2011 until October 2017, 120 patients (mean age: 51.8 years) underwent randomization. PFO size, frequency of septal aneurysm (13.3% vs. 8.3%; p = 0.56), and hypermobility (45.0% vs. 46.7%; p > 0.99) were similar between the groups. All PFO closures were successful. The primary endpoint occurred exclusively in the medication-only group (6 of 60 patients; 2-year event rate: 12.9% [log-rank p = 0.013]; 2-year rate of ischemic stroke: 10.5% [p = 0.023]). The events in the medication-only group included ischemic stroke (n = 5), cerebral hemorrhage (n = 1), Thrombolysis In Myocardial Infarction–defined major bleeding (n = 2), and transient ischemic attack (n = 1). Nonfatal procedural complications included development of atrial fibrillation (n = 2), pericardial effusion (n = 1), and pseudoaneurysm (n = 1).Conclusions
PFO closure in patients with high-risk PFO characteristics resulted in a lower rate of the primary endpoint as well as stroke recurrence. (Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale [DEFENSE-PFO]; NCT01550588) 相似文献
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