This paper describes the design of a theory-informed pragmatic intervention for adolescent perinatal depression in primary care in Nigeria.
Methods
We conducted Focus Group Discussions (FGDs) among 17 adolescent mothers and 25 maternal health care providers with experience in the receipt and provision of care for perinatal depression. The Consolidated Framework for Implementation Research (CFIR) was used to systematically examine the barriers and facilitators affecting adolescent mothers' use of an existing intervention package for depression. The Theoretical Domain Framework (TDF) and the Capability, Opportunity, Motivation, Behaviour (COM-B) model were used to analyze the results of the data across the five CFIR domains.
Results
FGD analysis revealed that care providers lacked knowledge on approaches to engage young mothers in treatment. Young mothers had poor treatment engagement, low social support, and little interest in parenting. A main characteristic of the newly designed intervention is the inclusion of age-appropriate psychoeducation supported with weekly mobile phone calls, to address treatment engagement and parenting behaviours of young mothers. Also in the outer setting, low social support from relatives was addressed with education, “as need arises” phone calls, and the involvement of "neighborhood mothers”. In the inner settings, care providers’ behaviour is addressed with training to increase their capacity to engage young mothers in treatment.
Conclusion
A theory-based approach helped develop an age-appropriate intervention package targeting depression and parenting skills deficit among perinatal adolescents in primary maternal care and in which a pragmatic use of mobile phone was key.
Pharmaceutical Research - Surface area and surface energy of pharmaceutical powders are affected by milling and may influence formulation, performance and handling. This study aims to decouple the... 相似文献
Immunization and appropriate health-seeking behavior are effective strategies to reduce child deaths.
Objectives
To compare maternal knowledge about immunization, use of growth chart and childhood health-seeking behavior in rural and urban areas.
Methods
A cross-sectional comparative study done in Lagos, Nigeria. Questionnaire survey and focus group discussions were done. 300 respondents were selected by multi-stage sampling while discussants were purposively selected.
Results
Awareness of immunization was high but knowledge of vaccine preventable diseases (VPDs) was poor in both areas. Urban women utilized preventive services more; growth monitoring (p<0.001) and immunization (p<0.001) while higher proportions of rural women utilized nutritional counseling (p=0.005) and treatment of illness (p<0.001). Growth chart utilization was better in the urban areas (p<0.001). Increasing maternal education increased use of growth chart in both areas. Both groups of women use multiple treatment sources for children (more in urban), determined by cost, time, perceived severity of illness and type of ailment (urban) and peculiarity of illness (rural). There is a preference for orthodox care in the rural area.
Conclusions
Knowledge of VPDs was poor and multiple treatment sources were common among rural and urban women. Education is vital to improve immunization knowledge and health-seeking behavior in both areas. 相似文献
The present study assessed developmental stages of third molar crowns in a group of Nigerian children and compared development across arches in relation to chronological age and sex.MethodologyPanoramic radiographs of 560 healthy Nigerian children aged 5 to 15 years were reviewed. The stages of development of third molar crowns across arches were assessed and determined using the criteria defined in Gravely's classification of crown formation. A score was recorded in each quadrant for each child. Data was analyzed using Epi-info 6 version for windows. Statistical significance was inferred at P < 0.05.ResultsMales 267 (47.7%), females 293 (52.3%). Mean age 10.4 years (SD52.5). Earliest evidence of crypt formation was observed at age 5.0. Mean age for stage 1 of crown calcification was 7.55, 7.75, 8.24 and 8.88 for the lower right, lower left, upper right and upper left quadrant of the jaws respectively. Differences observed between males and females were significant for stage 1 upper right molar crown development, (P = 0.03). In children 12 years and above, approximately 75% of the crowns visible on radiographs were at least half formed. Mean age for stage 5 of crown formation and initiation of root formation was between 13.10 and 13.43 years. The proportion of agenesis among children aged 12 years and above was 0.7.ConclusionsThe first sign of third molar crown development was observed as early as age 5. A positive correlation was observed between third molar development and chronological age. Proportion of agenesis in children aged 12 years and above was 0.7. 相似文献
The synthesis of five 2-arylnaphtho[2,3-d]oxazole-4,9-dione derivatives was accomplished by refluxing 2-amino-3-bromo-1,4-naphthoquinone with appropriate benzoyl chloride analogs at elevated temperatures. In vitro anticancer evaluation of these compounds was performed on androgen-dependent, LNCaP, and androgen-independent, PC3, human prostate cancer cell lines. In general, these compounds displayed slightly stronger cytotoxicity on the androgen-dependent LNCaP than on the androgen-independent PC3 prostate cancer cell lines. The meta-substituted 2-(3-Chloro-phenyl)-naphtho[2,3-d]oxazole-4,9-dione (10) appear to display the best cytotoxicity on both cell lines with an IC(50) of 0.03 μM on LNCaP and 0.08 μM on PC3 after 5 days of exposure. 相似文献