全文获取类型
收费全文 | 1890篇 |
免费 | 135篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 83篇 |
妇产科学 | 37篇 |
基础医学 | 273篇 |
口腔科学 | 28篇 |
临床医学 | 183篇 |
内科学 | 333篇 |
皮肤病学 | 63篇 |
神经病学 | 204篇 |
特种医学 | 53篇 |
外科学 | 179篇 |
综合类 | 16篇 |
预防医学 | 172篇 |
眼科学 | 59篇 |
药学 | 101篇 |
中国医学 | 4篇 |
肿瘤学 | 230篇 |
出版年
2023年 | 19篇 |
2022年 | 24篇 |
2021年 | 51篇 |
2020年 | 35篇 |
2019年 | 57篇 |
2018年 | 37篇 |
2017年 | 41篇 |
2016年 | 53篇 |
2015年 | 50篇 |
2014年 | 70篇 |
2013年 | 88篇 |
2012年 | 150篇 |
2011年 | 155篇 |
2010年 | 87篇 |
2009年 | 79篇 |
2008年 | 110篇 |
2007年 | 112篇 |
2006年 | 102篇 |
2005年 | 111篇 |
2004年 | 96篇 |
2003年 | 106篇 |
2002年 | 98篇 |
2001年 | 22篇 |
2000年 | 18篇 |
1999年 | 26篇 |
1998年 | 16篇 |
1997年 | 15篇 |
1996年 | 9篇 |
1995年 | 15篇 |
1994年 | 9篇 |
1993年 | 8篇 |
1992年 | 15篇 |
1991年 | 13篇 |
1990年 | 12篇 |
1989年 | 8篇 |
1988年 | 4篇 |
1987年 | 9篇 |
1986年 | 12篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 10篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1978年 | 7篇 |
1977年 | 3篇 |
1975年 | 5篇 |
1974年 | 5篇 |
1973年 | 3篇 |
排序方式: 共有2029条查询结果,搜索用时 31 毫秒
1.
2.
3.
A hypothesis for reactivation of pulmonary tuberculosis: How thoracic wall shape affects the epidemiology of tuberculosis
下载免费PDF全文
![点击此处可从《Clinical anatomy (New York, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Aaron R. Casha Liberato Camilleri Alexander Manché Ruben Gatt Daphne Attard Wiktor Wolak Krzysztof Dudek Marilyn Gauci Christopher Giordimaina Joseph N. Grima 《Clinical anatomy (New York, N.Y.)》2015,28(5):614-620
This study was aimed at determining the cause for the high incidence of tuberculosis (TB) reactivation occurring in males with a low body mass index (BMI). Current thinking about pulmonary TB describes infection in the lung apex resulting in cavitation after reactivation. A different hypothesis is put forward for TB infection, suggesting that this occurs in subclinical apical cavities caused by increased pleural stress due to a low BMI body habitus. A finite element analysis (FEA) model of a lung was constructed including indentations for the first rib guided by paramedian sagittal CT reconstructions, and simulations were conducted with varying antero‐posterior (AP) diameters to mimic chests with a different thoracic index (ratio of AP to the transverse chest diameters). A Pubmed search was conducted about gender and thoracic index, and the effects of BMI on TB. FEA modeling revealed a tenfold increase in stress levels at the lung apex in low BMI chests, and a four‐fold increase with a low thoracic index, r2 = 0.9748 P < 0.001. Low thoracic index was related to BMI, P = 0.001. The mean thoracic index was statistically significantly lower in males, P = 0.001, and increased with age in both genders. This article is the first to suggest a possible mechanism linking pulmonary TB reactivation to low BMI due to the flattened thoracic wall shape of young male adults. The low thoracic index in young males may promote TB reactivation due to tissue destruction in the lung apex from high pleural stress levels. Clin. Anat. 28:614–620, 2015. © 2015 Wiley Periodicals, Inc. 相似文献
4.
Because spitzoid melanoma shares many histopathologic features with Spitz nevus, it is one of the most difficult lesions to diagnose in dermatopathology. Uncertainty exists in the medical literature about how to diagnose melanocytic proliferations including Spitz nevus and spitzoid melanoma. A misdiagnosis of a melanoma as Spitz nevus is one of the most frequent causes of malpractice lawsuits in surgical pathology and dermatopathology. This contribution provides a review of the clinical presentation, histopathology, ancillary studies, treatment, and the differential diagnosis of spitzoid melanoma. 相似文献
5.
Judith D. DePue Elizabeth L. McQuaid Daphne Koinis-Mitchell Christopher Camillo Anthony Alario Robert B. Klein 《The Journal of asthma》2007,44(6):449-453
Over 3 years, 972 families participated in an after-school asthma program at their child's school. Parents and children attended concurrent 21/2 -hour workshops. Parents were 74% Latino; 45% non-English speaking, with 77% of children on Medicaid. Asthma symptoms were significantly reduced, from multiple times per week to less than once per week on average. Oral steroid use decreased to one third of baseline use. Hospital days decreased from 11% to 2%; emergency visits decreased 35% to 4%; and school days missed decreased 48% to 20%. This program has now become sustainable with both private and Medicaid insurance coverage. 相似文献
6.
7.
Yossi Gilgun-Sherki Yael Barhum Daphne Atlas Eldad Melamed Daniel Offen 《Journal of molecular neuroscience : MN》1996,27(1):125-135
Accumulating data from experimental studies indicate that oxidative stress has a major role in the pathogenesis of multiple
sclerosis (MS). It has been suggested that local production of reactive oxygen species, probably by macrophages, mediates
axonal damage in both MS patients and the mouse model experimental autoimmune encephalomyelitis (EAE). We have shown previously
that our novel brain-penetrating antioxidant, N-acetylcysteine amide (AD4), reduces the clinical and pathological symptoms, including inflammation and axonal damage in myelin
oligodendrocyte glycoprotein (MOG)-induced chronic EAE in mice. The aim of this study was to examine the molecular mechanism
by which AD4 exerts protection in MOG-induced EAE mice. Therefore, we analyzed gene-expression profile in the spinal cords
of MOG-induced chronic EAE mice and compared them with MOG-induced mice treated with AD4, using a cDNA microarray. We found
that MOG treatment up-regulated genes encoding growth factors, cytokines, death receptors, proteases, and myelin structure
proteins, whereas MOG- and AD4-treated mice demonstrated gene expression profiles similar to that seen in na?ve healthy mice.
In conclusion, our study shows that chronic AD4 administration suppresses the induction of various pathological pathways that
play a role in EAE and probably in MS. 相似文献
8.
Tomas Ojeda Deodato Radic Ligia Gargallo Daphne Boys 《Macromolecular chemistry and physics.》1980,181(11):2237-2244
Poly[4-(1,1,3,3-tetramethylbutyl)phenyl methacrylate] ( 1a ) was synthesized and its physicochemical properties were determined in the condensed phase and in dilute solution. The polymerization of 4-(1,1,3,3-tetramethylbutyl)phenyl methacrylate was carried out by radical mechanism in solution with 2,2′-azoisobutyronitrile as initiator. Several samples were characterized by their intrinsic viscosity, by osmometric measurements, differential scanning calorimetry, and X-ray diffraction. The viscometric behaviour of fractions of 1a was studied in good solvents and theta solvents, and the conformational parameters were calculated. Polymer 1a presents an unusual high rigidity in the chain. X-Ray diffraction of this polymer indicates a one-dimensional ordering of a mesomorphic type. 相似文献
9.
Mutational screening of APP gene in patients with early-onset Alzheimer disease utilizing mismatched PCR-RFLP 总被引:1,自引:0,他引:1
Yumiko Nishiwaki Kouzin Kamino Aoi Yoshiiwa Keiko Nagano Masatoshi Takeda Hirotaka Tanabe Tsuyoshi Nishimura Toshiko Kobayashi Hideki Yamamoto Yasuhiro Nonomura Hiroshi Yoneda Toshiaki Sakai Masaki Imagawa Tetsuro Miki Toshio Ogihara 《Clinical genetics》1996,49(3):119-123
To elucidate the frequency of mutations of the β/A4 amyloid protein precursor (APP) gene in early-onset Alzheimer disease, we designed a mismatched PCR-RFLP that can identify all kinds of missense mutations at codon 717 in addition to the seven kinds of known mutations at exon 17. When we screened mutations at exon 17 utilizing this method and the double missense mutations at exon 16 of the APP gene by PCR-RFLP, no cases revealed mutations of the APP gene among 13 familial and 54 sporadic cases, except one family (OS-1) that had previously been reported and used as a positive control of APP717(Val → Ile). Our results support the hypothesis that mutations in the APP gene are not major causes in early-onset Alzheimer disease. 相似文献
10.
Evaluation of Murex CMV DNA Hybrid Capture Assay for Detection and Quantitation of Cytomegalovirus Infection in Patients following Allogeneic Stem Cell Transplantation
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Holger Hebart Daphne Gamer Juergen Loeffler Claudia Mueller Christian Sinzger Gerhard Jahn Peter Bader Thomas Klingebiel Lothar Kanz Hermann Einsele 《Journal of clinical microbiology》1998,36(5):1333-1337
Murex hybrid capture DNA assay (HCS) is a solution hybridization antibody capture assay for detection and quantitation of cytomegalovirus (CMV) DNA in leukocytes. To determine whether CMV HCS is sensitive enough to initiate and monitor antiviral therapy after allogeneic stem cell transplantation (SCT), 51 consecutive SCT recipients were prospectively screened for the appearance of CMV infection by HCS, PCR, and culture assays from blood samples. Preemptive antiviral therapy was initiated after the second positive PCR result in all patients, as previously reported, and HCS was not considered for clinical decision making. A total of 417 samples were analyzed. Of these, 21 samples were found to be positive by PCR and HCS, 88 samples were PCR positive but HCS negative, and 308 were negative by both assays. Concordance of results between PCR and HCS and between HCS and blood culture was observed in 78.9 and 95.9% of the samples assayed, respectively. PCR was found to be more sensitive than HCS, and HCS was more sensitive than the blood culture assay (P < 0.0001). Four patients with symptomatic CMV infection were PCR positive prior to the onset of CMV-related symptoms, whereas HCS detected CMV DNA in three patients prior to and one at onset of CMV disease. The numbers of genomes per milliliter of blood were higher in patients with symptomatic CMV infection than in those with asymptomatic CMV infection (P = 0.06). None of the HCS-negative patients developed CMV disease. Thus, all patients with CMV disease were correctly identified by HCS; however, the lower sensitivity limit of the HCS assay may still be insufficient to allow diagnosis of CMV infection early enough to prevent CMV disease in patients following allogeneic SCT. 相似文献